Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 276, P. 109804 - 109804
Published: Nov. 25, 2023
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 757 - 757
Published: March 7, 2024
Isothiocyanates are biologically active products resulting from the hydrolysis of glucosinolates predominantly present in cruciferous vegetables belonging to Brassicaceae family. Numerous studies have demonstrated diverse bioactivities various isothiocyanates, encompassing anticarcinogenic, anti-inflammatory, and antioxidative properties. Nature harbors distinct isothiocyanate precursors, such as glucoraphanin gluconastrin, each characterized by unique structures, physical properties, pharmacological potentials. This comprehensive review aims consolidate current understanding Moringa mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates sulforaphane phenyl ethyl isothiocyanates. The focus is directed toward elucidating differences similarities efficacy these compounds agents anticancer,
Language: Английский
Citations
20
Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)
Published: Jan. 1, 2024
Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions
Language: Английский
Citations
19
Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1445 - 1445
Published: July 18, 2023
The tripeptide glutathione plays important roles in many cell processes, including differentiation, proliferation, and apoptosis; fact, disorders homeostasis are involved both the etiology progression of several human diseases, cancer. Natural compounds have been found to modulate levels function beyond their role as mere antioxidants. For example, certain can upregulate expression glutathione-related enzymes, increase availability cysteine, limiting amino acid for synthesis, or directly interact with its function. These may therapeutic potential a variety disease states where dysregulation is contributing factor. On other hand, flavonoids’ deplete could be significant cancer treatment. Overall, while natural and/or preventive properties able levels, more research needed fully understand mechanisms action benefits prevention treatment diseases. In this review, particular emphasis will placed on phytochemical belonging class polyphenols, terpenoids, glucosinolates that an impact physiological pathological conditions. classes secondary metabolites represent most food-derived bioactive intensively explored studied last few decades.
Language: Английский
Citations
29
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 522 - 522
Published: Jan. 8, 2025
The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been subject thousands studies over 125 clinical trials. many mechanisms action mammalian systems have extensively documented. is most potent naturally occurring inducer Keap1/Nrf2 pathway, which well-known for upregulation antioxidant detoxification activation pathways resulting inhibition inflammation. Much this regulation involves various hormonal axes body. However, influence on hormone-mediated health conditions remains unexplored recent scholarly reviews. This review aims to address gap by exploring these interactions, with a focus wellness issues specific both females males.
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and lipid peroxidation, has been implicated in wide range clinical conditions including neurological diseases, cardiovascular disorders, acute kidney failure, various types cancer. Therefore, it is critical to suppress cancer progression proliferation. Ferroptosis can be triggered cells some normal synthetic substances, such as erastin, Ras-selective lethal small molecule-3, or pharmaceuticals. Natural bioactive compounds are traditional drug discovery tools, have therapeutically used dietary additives pharmaceutical agents against malignancies. The fact that natural products multiple targets minimal side effects led notable advances anticancer research. Research indicated ferroptosis also induced during treatment. In this review, we focused the most recent developments emerging molecular processes significance To provide new perspectives future development ferroptosis-related medications, summary implications phytochemicals triggering through ROS production ferritinophagy induction variety
Language: Английский
Citations
7
Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5986 - 5986
Published: Dec. 19, 2024
Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis precursors known glucosinolates. ITCs have been studied extensively both vivo and vitro to define their therapeutic potential for treatment chronic health conditions. Therapeutically, they shown an intrinsic ability inhibit oxidative inflammatory phenotypes support enhanced health. This review summarizes current evidence supporting observation that antioxidant anti-inflammatory activities temper pathogenic effects metabolites called advanced glycation end products (AGEs). AGE exposure has significantly increased across lifespan due risk factors include dietary intake, sedentary lifestyle, comorbid By contributing cycle stress through aberrant activation transmembrane receptor (RAGE), bioavailability is associated with disease onset, progression, severity. debates molecular mechanisms which may reduce RAGE-mediated pro-oxidant pro-inflammatory phenotypes. Bringing light impact on biogenesis stimulate novel intervention strategies reversing or preventing lifestyle risk.
Language: Английский
Citations
1
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 276, P. 109804 - 109804
Published: Nov. 25, 2023
Language: Английский
Citations
2