Physical activity and exercise health benefits: cancer prevention, interception, and survival

European Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: 34(1), P. 24 - 39

Published: May 29, 2024

Physical activity (PA) has an established role in the promotion of health and fitness prevention disease. Expected overall benefits include reduction all-cause morbidity death, weight control, improved quality life, bone decreased falls elderly subjects, , deeper cognition, reduced risk depression, anxiety, sleeplessness. Currently, PA is a mainstay management cardiovascular diseases, metabolic syndrome, diabetes, health. Recently, perception its primary secondary prevention, interception, treatment cancer, however, also gaining importance. Regular walking, simplest type PA, associated with disease mortality, cancer increasing interest. Furthermore, improves life patients, attenuating side effects chemotherapy, decreasing sarcopenia, fitness, inhibiting recurrence progression some types. It promotes emotional psychological inducing positive changes. While mechanisms, effective levels useful amount practice are well cardiology, they yet to be fully determined oncology. Nevertheless, recommended reduce general population, it been introduced programs for second cancers. In perspective, will help as integrative therapy patients survivors. The number beneficial continuum highlighted this review.

Language: Английский

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Evolution of resistance training in women: History and mechanisms for health and performance

Sports Medicine and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Neutrophil-to-lymphocyte ratio is associated with accelerometer-measured physical activity levels in breast cancer survivors

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(3)

Published: Feb. 12, 2025

Language: Английский

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Effects of a 6-month rowing training program in breast cancer survivors

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317118 - e0317118

Published: Jan. 22, 2025

The purpose of this longitudinal study was to determine the effects a rowing training program on physical fitness and body composition in female breast cancer survivors (56.78 ± 6.38 years). Over six months, participants (n = 40) performed two sessions per week for an average 75 minutes, combining resistance muscle strength exercises with rowing. To evaluate impact program, tests anthropometric measurements were carried out before after protocol. results show statistically significant improvements measures such as weight (-1.84 kg), BMI (-0.7 kg/m2), hip (-3.24 cm) waist circumference (-2.45 cm). In addition, variables associated also improved including leg (3.04 cm), dominant handgrip (4.24 kgf), non-dominant (3.49 aerobic endurance (78.35 m) flexibility (3.96 We can therefore conclude that rowing-based exercise is effective strategy improve type population, yielding both basic capacity variables, essential factors better health quality life.

Language: Английский

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Harnessing the Role of ESR1 in Breast Cancer: Correlation with microRNA, lncRNA, and Methylation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3101 - 3101

Published: March 27, 2025

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that encoded by gene 1 (ESR1), which modulates signaling. ESR1, facilitating overproduction, plays an indispensable role in progression survival of majority BCs. To obtain molecular insights into these phenomena, we analyzed The Cancer Genome Atlas (TCGA) breast invasive carcinoma (BRCA) RNA-Seq datasets for expression ESR1 its correlation to microRNAs (miRNAs) long non-coding RNAs (lncRNAs), along with methylation patterns. Regulation was also assessed total 43 cancerous non-cancerous cell lines. Analyses both TCGA BRCA line data revealed specific lncRNAs, i.e., MEG3, BIK, MLL, FAS are negatively correlated PARP1 demonstrates positive association. Additionally, miR-30a miR-145 showed negative correlations expression. Of 54 loci analyzed, them exhibited expression, highlighting potentially modifiable regulatory mechanism. These findings underscore complex events influencing interaction diverse signaling pathways, demonstrating novel pathogenesis potential therapeutics.

Language: Английский

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Prähabilitation und Sport in der Onkologie

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Numerous randomized controlled trials confirm the clinical importance of exercise therapy in management side effects cancer treatment. Physically active patients also have a better prognosis. Since it has been known that physical performance level before surgery is strong prognostic factor for occurrence perioperative complications, focus interest on therapy-based prehabilitation. Studies this field show even very short interventions (2-4 weeks) can achieve lower complication rates, particularly pulmonary complications. Even if evidence still limited, be concluded every patient should offered prehabilitation preparation major or gastrointestinal surgical interventions. However, there are so far hardly any treatment structures make currently possible.

Language: Английский

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The exercise-conditioned human serum and skeletal muscle cells secretome induce apoptosis in breast cancer cells

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101051 - 101051

Published: May 1, 2025

Regular exercise training provides significant health benefits among cancer survivors and is associated with lower breast mortality reduced risk of recurrence. Both exercise-induced factors secreted into circulation (exerkines) bioactive molecules contained in skeletal muscle secretome have been proposed to affect the tumor microenvironment mediate some anti-carcinogenic effects exercise. This study utilized exercise-conditioned human serum obtained from patients during chemotherapy myotubes' after mechanical loading investigate their on cells vitro. Breast participated a 12-week program chemotherapy, blood was collected immediately before an session 2nd 12th weeks training. Skeletal myoblasts were differentiated myotubes subjected stretching collect (stretch medium (SM)). Hormone-sensitive Michigan Cancer Foundation-7 (MCF-7) triple-negative M.D. Anderson-Metastatic Breast-231 (MDA-MB-231) treated either or examine metabolic activity, migration, cytotoxicity levels apoptosis regulation. The who resulted activity (p < 0.001) increased lactate dehydrogenase (LDH) (cytotoxicity) both MCF-7 MDA-MB-231 when compared control condition. Moreover, incubation post-exercise induced cells, as indicated by increase DNA damage percentage necrotic 0.05) pre-exercise Similarly, decrease observed SM, along 0.05), cultured regular growth media. Comparable though not profound SM secretome. Furthermore, expression apoptosis-inducing caspase-7 caspase-8 0.01) proteins increased, whereas cell survival-regulating interleukin-8 (IL-8) 0.001), superoxide dismutase-2 (SOD-2) Fas surface death receptor (Fas) vascular endothelial factor (VEGF) downregulated SM-treated cells. In addition, migrating behavior diminished, higher non-stretch media (NSM). can reduce promote toxicity damage, modulate protein crucial factors, lead These findings suggest that even diagnosis, may exert beneficial additive against prognosis.

Language: Английский

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The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1667 - 1667

Published: March 29, 2023

A healthy diet and an active lifestyle are both effective ways to prevent, manage, treat many diseases, including cancer. healthy, well-balanced not only ensures that the body gets right amount of nutrients meet its needs, but it also lets get substances protect against and/or prevent certain diseases. It is now clear obesity linked long-term diseases such as heart disease, diabetes, The main reasons for people being overweight or obese having bad eating habits moving around enough. Maintaining weight in normal range may be one best things avoid has been scientifically proven those who perform regular physical activity less likely develop cancer than lead a sedentary lifestyle. Moving regularly helps maintain weight, avoiding effects favor tumor growth subjects, makes immune system more resistant by counteracting cells. Physical cardiovascular metabolic In this review, highlighted association between Mediterranean triggers biological mechanisms capable low-grade chronic inflammation found patients with This assumes lifestyles associated therapies can improve expectations quality life patients.

Language: Английский

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Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(3)

Published: Feb. 21, 2024

Language: Английский

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Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research

Journal of Cancer, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 19

Published: Dec. 5, 2023

In recent years, accumulating evidence from preclinical and clinical studies consistently indicated that physical activity/exercise plays a crucial role in reducing the incidence recurrence of various malignancies, by exerting beneficial modulation cancer hallmarks.Moreover, activity is suggested to attenuate certain adverse effects anticancer therapy, including reduction cardiovascular toxicity symptoms related depression anxiety, among others, while preserving muscular strength.In case melanoma, relationship with has been critically debated.Historically, several cohort meta-analyses reported positive association between melanoma risk.This was primarily attributed outdoor activities may expose skin UV radiation, well-known risk factor for melanocyte transformation.However, more does not support such recognizes both prevention progression.Nevertheless, sun protection recommended during training minimize radiation exposure.This narrative review summarizes data about on hallmarks.Specifically, experimental concerning (i) invasion metastasis, (ii) reprogramming energy metabolism, (iii) angiogenesis, (iv) resistance cell death, (v) evasion immune destruction, (vi) tumor-promoting inflammation.

Language: Английский

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