Embracing cancer complexity: Hallmarks of systemic disease

Cell, Journal Year: 2024, Volume and Issue: 187(7), P. 1589 - 1616

Published: March 1, 2024

Language: Английский

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Precision treatment in advanced hepatocellular carcinoma

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(2), P. 180 - 197

Published: Feb. 1, 2024

The past decade has witnessed significant advances in the systemic treatment of advanced hepatocellular carcinoma (HCC). Nevertheless, newly developed strategies have not achieved universal success and HCC patients frequently exhibit therapeutic resistance to these therapies. Precision represents a paradigm shift cancer recent years. This approach utilizes unique molecular characteristics individual patient personalize modalities, aiming maximize efficacy while minimizing side effects. Although precision shown multiple types, its application remains infancy. In this review, we discuss key aspects HCC, including biomarkers, classifications, heterogeneity tumor microenvironment. We also propose future directions, ranging from revolutionizing current methodologies personalizing therapy through functional assays, which will accelerate next phase advancements area.

Language: Английский

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Definition and diagnostic criteria of clinical obesity

The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 800 - 800

Published: March 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Language: Английский

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Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Jan. 1, 2025

Language: Английский

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A Bibliometric Analysis on the Risk Factors of Cancer

Genes Chromosomes and Cancer, Journal Year: 2025, Volume and Issue: 64(1)

Published: Jan. 1, 2025

ABSTRACT Given the high lethality of cancer, identifying its risk factors is crucial in both epidemiology and cancer research. This study employs a novel bibliometric analysis method, which uses tidytext package tidy tools R. approach surpasses traditional like VOSviewer, offering more comprehensive complex keyword data clearer results compared to Bibliometrix. By using R, researchers can efficiently handle useful keywords, ignore irrelevant terms, adjust specific settings, correct errors such as repeated evaluations. examines 1000 articles sourced from Web Science database, advanced R Studio analyze publication quantity, frequency, word co‐occurrences. The primary goal uncover key associated with explore underlying mechanisms that link these development. Risk are categorized into exogenous (environmental exposures lifestyle choices) endogenous (genetic predispositions hormonal imbalances). providing factors, aims deepen our understanding risk. research contributes valuable insights broader field has potential inform future studies strategies for prevention treatment.

Language: Английский

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Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1086 - 1086

Published: July 31, 2023

Cancer is one of the leading causes death worldwide, affecting millions people each year. Fortunately, last decades have been marked by considerable advances in field cancer therapy. Researchers discovered many natural substances, some which are isolated from plants that promising anti-tumor activity. Among these, essential oils (EOs) and their constituents widely studied shown potent anticancer activities, both vitro vivo. However, despite results, precise mechanisms action EOs bioactive compounds still poorly understood. Further research needed to better understand these mechanisms, as well effectiveness safety use. Furthermore, use drugs complex, it requires absolute pharmacodynamic specificity selectivity, an appropriate formulation for effective administration. In this study, we present a synthesis recent work on compounds, examining results various vivo studies. We also review future prospects exciting field, potential implications development new drugs.

Language: Английский

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Gastric Cancer Risk in Association with Underweight, Overweight, and Obesity: A Systematic Review and Meta-Analysis

Cancers, Journal Year: 2023, Volume and Issue: 15(10), P. 2778 - 2778

Published: May 16, 2023

This study aimed to investigate the risk of gastric cancer (GC) in abnormal body mass index (BMI) groups. A systematic search was carried out on Embase, PubMed/Medline, and Scopus from January 2000 2023. The pooled ratio (RR) with a 95% confidence interval (CI) assessed using random-effect model. Thirteen studies total 14,020,031 participants were included this review. RR GC 1.124 (95% CI, 0.968–1.304, I2: 89.08%) underweight class, 1.155 1.051–1.270, 95.18%) overweight 1.218 1.070–1.386, 97.65%) obesity class. There is no difference between cardia non-cardia cancer, while non-Asian race female gender have higher as Meta-regression classes showed. These findings suggest that there positive association excess weight GC, impact women than men Asian populations. Since tied various diseases, including healthcare experts, policymakers should continue interventions aiming achieve normal BMI range.

Language: Английский

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Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2024, Volume and Issue: 23(3), P. 3696 - 3696

Published: April 1, 2024

Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.

Language: Русский

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Dysmetabolic comorbidities and non-alcoholic fatty liver disease: a stairway to metabolic dysfunction-associated steatotic liver disease

Hepatoma Research, Journal Year: 2024, Volume and Issue: 10, P. 16 - 16

Published: Jan. 1, 2024

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic disease. This term does not describe pathogenetic mechanisms and complications associated with NAFLD. The new definition, Metabolic Dysfunction-associated Steatotic Liver (MASLD), emphasizes relationship between NAFLD cardiometabolic comorbidities. Cardiovascular features, such as arterial hypertension atherosclerosis, are frequently patients MASLD. Furthermore, these have a high risk developing neoplastic diseases, primarily hepatocellular carcinoma, but also extrahepatic tumors, esophageal, gastric, pancreatic cancers. Moreover, several studies showed correlation MASLD endocrine imbalance gut microbiota, systemic inflammation, obesity, insulin resistance play key role in development complications. narrative review aims to clarify evolution from nomenclature evaluate its

Language: Английский

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