Heliyon,
Journal Year:
2024,
Volume and Issue:
11(1), P. e41483 - e41483
Published: Dec. 25, 2024
Cisplatin
(CDDP)
is
one
of
the
main
chemotherapeutic
drugs
that
widely
used
in
many
cancers.
However,
CDDP
resistance
a
frequent
therapeutic
challenge
reduces
prognosis
cancer
patients.
Since,
has
noticeable
side
effects
normal
tissues
and
organs,
it
necessary
to
assess
molecular
mechanisms
associated
with
improve
methods
Drug
efflux,
detoxifying
systems,
DNA
repair
mechanisms,
drug-induced
apoptosis
are
involved
multidrug
CDDP-resistant
tumor
cells.
Mammalian
target
rapamycin
(mTOR),
as
serine/threonine
kinase
pivotal
role
various
cellular
such
autophagy,
metabolism,
drug
cell
proliferation.
Although,
mTOR
mainly
activated
by
PI3K/AKT
pathway,
can
also
be
regulated
other
signaling
pathways.
PI3K/Akt/mTOR
axis
functions
key
modulator
unfavorable
different
Regarding,
response,
present
review
we
discussed
regulate
mediated
response
Cytokine & Growth Factor Reviews,
Journal Year:
2023,
Volume and Issue:
71-72, P. 66 - 81
Published: June 1, 2023
Mechanistic
target
of
rapamycin
(mTOR),
a
highly
conserved
serine/threonine
kinase,
is
involved
in
cellular
metabolism,
protein
synthesis,
and
cell
death.
Programmed
death
(PCD)
assists
eliminating
aging,
damaged,
or
neoplastic
cells,
indispensable
for
sustaining
normal
growth,
fighting
pathogenic
microorganisms,
maintaining
body
homeostasis.
mTOR
has
crucial
functions
the
intricate
signaling
pathway
network
multiple
forms
PCD.
can
inhibit
autophagy,
which
part
PCD
regulation.
Cell
survival
affected
by
through
autophagy
to
control
reactive
oxygen
species
production
degradation
pertinent
proteins.
Additionally,
regulate
an
autophagy-independent
manner
affecting
expression
levels
related
genes
phosphorylating
Therefore,
acts
both
autophagy-dependent
-independent
pathways
It
conceivable
that
exerts
bidirectional
regulation
PCD,
such
as
ferroptosis,
according
complexity
networks,
but
underlying
mechanisms
have
not
been
fully
explained.
This
review
summarizes
recent
advances
understanding
mTOR-mediated
regulatory
Rigorous
investigations
into
PCD-related
provided
prospective
therapeutic
targets
may
be
clinically
beneficial
treating
various
diseases.
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
15(2), P. 714 - 714
Published: Aug. 2, 2023
Ferroptosis,
a
type
of
cell
death
involving
iron
and
lipid
peroxidation,
has
been
found
to
be
closely
associated
with
the
development
many
diseases.
Mitochondria
are
vital
components
eukaryotic
cells,
serving
important
functions
in
energy
production,
cellular
metabolism,
apoptosis
regulation.
Presently,
precise
relationship
between
mitochondria
ferroptosis
remains
unclear.
In
this
study,
we
aim
systematically
elucidate
mechanisms
via
which
regulate
from
multiple
perspectives
provide
novel
insights
into
mitochondrial
ferroptosis.
Additionally,
present
comprehensive
overview
how
contribute
different
conditions,
including
cancer,
cardiovascular
disease,
inflammatory
DNA
depletion
syndrome,
coronavirus
pneumonia.
Gaining
understanding
involvement
could
lead
more
effective
approaches
for
both
basic
biology
studies
medical
treatments.
Journal of Cellular and Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
27(7), P. 920 - 926
Published: March 5, 2023
Abstract
Obesity
is
widely
recognized
as
a
major
global
health
problem
caused
by
chronic
energy
imbalance
resulting
from
combination
of
excess
caloric
intake
and
insufficient
expenditure.
Excessive
physical
inactivity
are
traditional
risk
factors
for
obesity.
factor
many
diseases,
including
hypertension,
diabetes
tumours.
Recent
studies
have
found
strong
link
between
ferroptosis
Ferroptosis
an
iron‐dependent
regulated
cell
death
iron
overload
reactive
oxygen
species‐dependent
excessive
accumulation
lipid
peroxidation.
involved
in
biological
processes,
such
amino
acid
metabolism,
metabolism
metabolism.
Some
potential
strategies
to
reduce
the
adverse
effects
on
obesity
suggested
future
research
priorities
highlighted.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 1, 2024
Myocardial
ischemia-reperfusion
injury
(MIRI)
is
a
significant
factor
in
the
development
of
cardiac
dysfunction
following
myocardial
infarction.
Ferroptosis,
type
regulated
cell
death
driven
by
iron
and
marked
lipid
peroxidation,
has
garnered
growing
interest
for
its
crucial
involvement
pathogenesis
MIRI.This
review
comprehensively
examines
mechanisms
ferroptosis,
focusing
on
regulation
through
metabolism,
VDAC
signaling,
antioxidant
system
dysregulation.
We
also
compare
ferroptosis
with
other
forms
to
highlight
distinct
characteristics.
Furthermore,
MIRI
examined
focus
recent
discoveries
concerning
ROS
generation,
mitochondrial
impairment,
autophagic
processes,
ER
stress,
non-coding
RNA
regulation.
Lastly,
emerging
therapeutic
strategies
that
inhibit
mitigate
are
reviewed,
providing
new
insights
into
potential
clinical
applications.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(4)
Published: April 1, 2025
Cancer
is
the
main
leading
cause
of
death
worldwide
and
poses
a
great
threat
to
human
life
health.
Although
pharmacological
treatment
with
chemotherapy
immunotherapy
therapeutic
strategy
for
cancer
patients,
there
are
still
many
shortcomings
during
such
as
incomplete
killing
cells
development
drug
resistance.
Emerging
evidence
indicates
promise
inducing
ferroptosis
treatment,
particularly
eliminating
aggressive
malignancies
that
resistant
conventional
therapies.
This
review
covers
recent
advances
in
important
regulatory
targets
metabolic
pathway
inducers
(focusing
mainly
on
last
3
years)
delineate
their
design,
mechanisms
action,
anticancer
applications.
To
date,
compounds,
including
inhibitors,
degraders,
active
molecules
from
traditional
Chinese
medicine,
have
been
demonstrated
ferroptosis-inducing
activity
by
targeting
different
biomolecules
pathway.
However,
strictly
defined
not
yet
approved
clinical
use;
therefore,
discovery
new
highly
active,
less
toxic,
selective
compounds
remains
goal
further
research
coming
years.
Virology Journal,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Oct. 24, 2023
African
swine
fever
virus
(ASFV)
is
one
of
the
most
fatal
etiological
agents
and
has
a
huge
economic
impact
on
global
pork
industry.
Given
that
no
effective
vaccines
or
anti-ASFV
drugs
are
available,
there
remains
pressing
need
for
novel
drugs.
This
study
aimed
to
investigate
anti-African
activity
brequinar,
DHODH
inhibitor.The
brequinar
was
investigated
using
IFA,
HAD,
HAD50,
qRT-PCR,
western
blotting
assays.
The
assay
used
whether
inhibits
ASFV
replication
by
killing
particles
directly
acting
cell
factors.
confocal
microscopy
assays
were
activating
ferroptosis.In
this
study,
found
effectively
inhibit
ex
vivo
in
porcine
alveolar
macrophages
(PAMs)
dose-dependent
manner.
In
kinetic
studies,
maintain
inhibition
from
24
72
hpi.
Mechanistically,
time-of-addition
showed
exerted
all
treatment
modes,
including
pre-,
co-,
post-treatment
rather
than
particles.
Notably,
FerroOrange,
Mito-FerroGreen,
Liperfluo
staining
experiments
increased
accumulation
intracellular
iron,
mitochondrial
lipid
peroxides,
respectively.
Furthermore,
we
also
ferroptosis
agonist
cisplatin
inhibited
manner
inhibitory
effect
partially
reversed
inhibitor
ferrostatin-1,
suggesting
activates
replication.
Interestingly,
exogenous
uridine
supplementation
attenuated
indicating
inhibiting
depletion
pyrimidine
pools;
however,
induction
not
supplementation,
activation
related
metabolic
function
pyrimidines.Our
data
confirm
displays
potent
antiviral
against
vitro
reveal
mechanism
which
ferroptosis,
independent
synthesis,
providing
targets
development
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 2661 - 2674
Published: June 1, 2023
Abstract:
Ferroptosis
is
a
novel
type
of
programmed
cell
death
involved
in
many
diseases'
pathological
processes.
characterized
by
lipid
peroxidation,
reactive
oxygen
species
accumulation,
and
iron
metabolism
disorder.
Newborns
are
susceptible
to
ferroptosis
due
their
special
physiological
state,
which
prone
abnormal
the
accumulation
species.
Recent
studies
have
linked
variety
diseases
neonatal
period
(including
hypoxic-ischemic
encephalopathy,
bronchopulmonary
dysplasia,
necrotizing
enterocolitis).
may
become
an
effective
target
for
treatment
neonatal-related
diseases.
In
this
review,
molecular
mechanism,
characteristics
infants,
relationship
between
common
infant
disorders,
targeted
systematically
summarized.
Keywords:
ferroptosis,
disease,
species,
metabolism,
peroxidation
