Impact of the Sars-Cov-2 outbreak on the initial clinical presentation of new solid cancer diagnoses: a systematic review and meta-analysis

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract Background The COVID-19 pandemic might have delayed cancer diagnosis and management. aim of this systematic review was to compare the initial tumor stage new diagnoses before after pandemic. Methods We systematically reviewed articles that compared solid waves. conducted a random-effects meta-analysis rate metastatic tumors distribution stages at diagnosis. Subgroup analyses were performed by primary site country. Results From 2,013 studies published between January 2020 April 2022, we included 58 with 109,996 patients. higher outbreak than (pooled OR: 1.29 (95% CI, 1.06-1.57), I 2 : 89% 86-91)). For specific cancers, common ORs reached statistical significance for breast (OR: 1.51 CI 1.07-2.12)) gynecologic 1.04-2.18)) but not other types. According countries, OR CI) only Italy: 1.55 (1.01-2.39) Spain:1.14 (1.02-1.29). Rates comparable I-II versus III-IV in which information available, III did include Conclusions Despite inter-study heterogeneity, our showed burden social distancing policies explain those results, as patients may seeking care.

Language: Английский

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Cancer incidence, stage shift and survival during the 2020 COVID‐19 pandemic: A population‐based study in Belgium

International Journal of Cancer, Journal Year: 2024, Volume and Issue: 155(7), P. 1212 - 1224

Published: May 10, 2024

The COVID-19 pandemic was associated with a profound decline in cancer diagnoses 2020 Belgium. Disruption diagnostic and screening services patient reluctance to visit health facilities led fewer new cases concerns that cancers may be diagnosed at more advanced stages hence have poorer prognosis. Using data from mandatory registration covering all of Belgium, we predicted incidence, stage distribution 1-year relative survival for using Poisson count model over the preceding years, extrapolated 11 common types. We compared these expected values observed specifically quantify impact pandemic, accounting background trends. A significantly lower incidence cervical, prostate, head neck, colorectal, bladder breast cancer, limited or no recovery second half Changes were ovarian fallopian tube tumours. Generally, changes mainly represented early-stage than late-stage One-year lung colorectal cancer. Stage shifts are hypothesised result alterations access diagnosis, potentially due prioritisation symptomatic patients, contact physician. Since there 5000 by end 2020, it is critical monitor coming years.

Language: Английский

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Clinical Presentation, Treatment Outcomes, and Demographic Trends in Vestibular Schwannomas: A 135-Case Retrospective Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 482 - 482

Published: Jan. 14, 2025

Background: This study presents a comprehensive analysis of 135 cases vestibular schwannoma (VS) treated between 2006 and 2022 at the National Institute Neurology Neurovascular Diseases in Bucharest, Romania. The investigation focuses on clinical presentation, treatment outcomes, demographic trends VS patients, highlighting region-specific insights that fill critical gaps Eastern European data. Methods: Patients were with either open surgery (93.3%) or gamma knife radiosurgery (6.6%). identifies predominant symptoms, including hearing impairment, facial palsy, balance disorders, variations observed across age gender subgroups. Comorbidities such as hypertension obesity prevalent, they influenced perioperative risks. Results: Post-treatment outcomes showed significant correlation symptoms modalities, majority achieving favorable results. findings emphasize need for tailored approaches management underscore importance factors influencing outcomes. Conclusions: contributes to refining strategies improving healthcare delivery patients Romania beyond.

Language: Английский

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Effect of Surface-engineered AuNPs on gene expression, bacterial interaction, protein denaturation, and toxicology assay: An in vitro and in vivo model

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We investigated the in vitro and vivo uses of pamoic acid functionalized gold nanoparticles (PA@AuNPs), with a focus on determining their safety potential toxicity living beings. To test this theory, bacterial interaction PA@AuNPs was studied using Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa cultures, as well inhibition bovine serum albumin (BSA) protein. The real-time polymerase chain reaction (RT-PCR) is used to measure expression target genes. caused dose-dependent cell death MDA-MB-231, triple-negative breast cancer (BC) line, an LC50 -42.23 μL mL-1. It also apoptosis BC cells. results indicated that early weeks, inflammatory cells (mostly neutrophils macrophages) penetrated connective tissue, but latter substantial number fibroblasts fibrocytes were identified. Changes vascular channels, extravasated red blood (RBCs), necrosis are all indicators growing tissue pathology. These data could point dynamic process including anti-inflammatory response followed by remodeling or repair. findings show not hazardous tested Sprague Dawley rats, highly biocompatible, can be variety biological applications.

Language: Английский

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A Final Report on the Real Impact of the COVID-19 Pandemic on the Diagnosis of Gastrointestinal Cancer in Akita Prefecture, Japan in 2022

The Tohoku Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 263(2), P. 161 - 168

Published: Jan. 1, 2024

The long-term impact of the coronavirus disease 2019 (COVID-19) pandemic on disruption gastrointestinal cancer diagnoses remains unclear. This study investigated actual esophagogastric (EGC) and colorectal (CRC) up to third year in Akita Prefecture, Japan, using population-based registry data. We collected data annual number EGC CRC a database from collaborative Prefecture hospital-based registration. net cancers diagnosed first three years (2020-2022) were compared with those before (2017-2019). Changes proportion stage initial treatment for after then compared. total EGCs was 9.3% lower than before, probably due its declining trend. CRCs exceeded that suggesting successful recovery diagnostic procedure. stages remained largely unchanged onset pandemic. Based pandemic, caused by is settling down without any substantial progression, even area highest incidence all Japan.

Language: Английский

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Predicting Survival of Metastatic Clear Cell Renal Cell Carcinoma Treated With Tyrosine Kinase Inhibitor Based Sequential Therapy

Published: July 26, 2024

(1) Objective: To develop a clinically useful nomogram that may provide more individualized and accurate estimation of cancer-specific survival (CSS) for patients with clear-cell (CC) metastatic renal cell carcinoma (mRCC) treated nephrectomy tyrosine kinase Inhibitor (TKI) based sequential therapy; (2) Methods: A prospectively maintained database 145 mRCC between 2008-2018 was analyzed to predict CSS receiving sunitinib 2nd 3rd line therapies according current standards practice. taking into account four independent clinical predictors (ECOG status, IMDC score, MASS RECIST response criteria) calculated. The corresponding 1- 10-year probabilities were then determined from the nomogram; (3) Results: median age 60 years (95% CI 57.9-61.4). Disease at diagnosis in 59 (40.7%) 86 (59.3%) developed metachronous metastasis after nephrectomy. Patients followed 48 (IQR 72; 95% 56-75.7) months first-line TKI initiation. Concordance probability estimator is 0.778 ± 0.02 (mean SE); (4) Conclusions: CC incorporates patient risk classification criteria 3 presented. This new tool be clinicians assessing prognosis mRCC.

Language: Английский

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Changes in breast cancer incidence and surgical treatment in Baden–Württemberg (Germany) during the COVID-19 pandemic

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 22, 2024

Abstract The COVID-19 pandemic affected the diagnostics and treatment of breast cancer. Numerous studies reported an early decline in cancer (BC) incidence during pandemic. Less evidence is available on changes medical care. Reports from individual patients have provided anecdotal for a shift breast-conserving surgery to mastectomy reduce number visits radiation units This study aimed explore BC surgical south Germany. Using data Baden-Württemberg Cancer Registry, age-standardized (ICD-10 C50 D05) (women) 2018–2021 was investigated overall by age stage using standardized ratios. Among pre-operative I/IIA patients, differences time type were negative binomial logistic regression models. invasive decreased significantly 170.9 per 100,000 women 2018/2019 159.7 2020 increased 169.2 2021. decrease resulted lower around April also observed non-invasive BC. In 2021, still 8% aged 80 + years. Surgical analyzed 22,708 with ≤ IIA. median 33 days 2018/2019, 32 36 proportion mastectomies 16.1% 17.1% 17.3% 2021 (adjusted odds ratio 95% confidence interval (2021 vs. 2018/2019): 1.13 (1.03–1.24)). adjusted increase strongest 50–59 years (1.34 (1.09–1.64)) those high-grade tumors (1.27 (1.07–1.51)). While return pre-pandemic rates promising, missed cases not been caught up until Furthermore, elderly warrants further attention. early-stage BC, slightly greater rate observed, although such change recommended. result underlines importance good communication adapted guidelines exceptional circumstances.

Language: Английский

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Three-year survival follow-up of patients with gastrointestinal cancer treated during the COVID-19 pandemic in Spain: data from the PANDORA-TTD20 study

The Oncologist, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Introduction The initial SARS-CoV-2 pandemic wave in Spain 2020 precipitated significant paradigm shifts gastrointestinal oncology patient management. This study captures the “Zeitgeist” of this period by analyzing adaptive strategies, treatment modifications, and survival outcomes, leveraging a 3-year follow-up perspective to extract insights from unprecedented experience. Methods We conducted multicenter, retrospective cohort utilizing RETUD-TTD registry, encompassing 703 patients across 19 Spanish centers April 2020. evaluated alterations clinical practice, therapeutic approaches, coronavirus disease 2019 (COVID-19)-related impacts, survival. A Bayesian hierarchical model was employed identify potential regional-specific frailties. Results peak catalyzed substantial oncological care delivery. Outpatient consultations decreased 13%, with notable selection bias toward cases more favorable prognostic indicators. Multidisciplinary tumor board discussions were significantly curtailed (eg, mean monthly colorectal cancer discussed reduced 40 23), compromising qualitative measures. occurred concurrently an average over 3 oncologists per center on medical leave. Contrary concerns, healthcare system demonstrated remarkable resilience. majority received standard-of-care therapies regulatory approval, albeit regimen modifications 15% cases. These adaptations included extended dosing intervals, dose intensity modulations, transitions oral formulations while maintaining unexpectedly stable long-term outcomes. frailty detected minimal unmeasured factors related geographic location, type pandemic-induced adaptation did not impact revealed that 2019’s less pronounced than other core variables. Conclusions decentralized exhibited robustness managing pre-pandemic diagnosed malignancies, despite asymmetrical, occasionally severe organizational disruptions. gleaned experience could inform future crisis preparedness strategies optimize provision during subsequent public health emergencies.

Language: Английский

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Impact of the COVID‐19 pandemic on clinical presentation, treatments, and outcomes of new breast cancer patients: A retrospective multicenter cohort study

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(22), P. 20918 - 20929

Published: Nov. 1, 2023

Abstract Background The SARS CoV‐2 pandemic disrupted healthcare systems. We compared the cancer stage for new breast cancers (BCs) before and during pandemic. Methods performed a retrospective multicenter cohort study on data warehouse of Greater Paris University Hospitals (AP‐HP). identified all female patients newly referred with BC in 2019 2020. assessed timeline their care trajectories, initial tumor stage, treatment received: resection, exclusive systemic therapy, radiation or best supportive (BSC). calculated patients' 1‐year overall survival (OS) indicators Results In 2020, 2055 1988, underwent treatment, two lockdowns, diagnoses varied by −18% +23% to 2019. De novo metastatic tumors (15% 15%, p = 0.95), pTNM ypTNM distributions 1332 cases upfront resection 296 neoadjuvant therapy did not differ ( 0.37, 0.3). median times from first multidisciplinary meeting diagnosis 19 days (interquartile 11–39 days) 35 22–65 differ. Access plastic surgery 17%, 0.08) categories vary: (73% 72%), (13% 14%), (9% 9%), BSC (5% 5%) 0.8). Among resected patients, rate was lower (16%) versus 2020 (20%) 0.02). One‐year OS rates were 99.3% 98.9% (HR 0.96; 95% CI, 0.77–1.2), 72.6% 76.6% 1.28; 0.95–1.72), 96.6% 97.8% 1.09; 0.61–1.94), 15.5% 15.1% 0.99; 0.72–1.37), groups. Conclusions Despite decrease number BCs, there no shift, vary.

Language: Английский

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The COVID-19 pandemic has revealed an increase in cancer diagnoses and a decrease in prehabilitation programs among patients in Transylvania

Balneo and PRM Research Journal, Journal Year: 2023, Volume and Issue: 14(Vol.14, no. 4), P. 600 - 600

Published: Dec. 20, 2023

Introduction: The COVID-19 pandemic has brought significant disruptions to the landscape of oncological medicine, resulting in postponed cancer diagnoses and treatments, poor implementation prehabilitation programmes, an overall altered general care. Purpose: This paper aims evaluate impact on profile patients admitted a clinical Hospital from Transylvania, its detrimental effect prehabilitation/rehabilitation programs for diagnosed with cancer. Material methods: study compared two groups patients, ones hospital year before (2019) others 2020. We recorded number new diagnoses, performed interventions we results. Results: diagnosis was statistically significantly more frequent 2020 same timeframe 2019. Additionally, fewer physical or rehabilitation were applied during period. Conclusions: had patient´s benefit

Language: Английский

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