Anelloviruses and Cancer DOI Creative Commons

Jason Y Tang,

T. Chen, Valentina L. Kouznetsova

et al.

The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 231(2), P. 298 - 306

Published: Dec. 14, 2024

Anelloviruses are among the most prevalent viruses within human virome, detected in >90% of healthy individuals. Despite their ubiquity, role anelloviruses health remains elusive. This review examines potential associations torque teno virus (TTV), midi (TTMDV), and mini (TTMV) with various cancers, highlighting mixed conclusions from current epidemiological studies. may modulate cancer development through abnormal gene fusion, immune response, Toll-like receptor 9 (TLR9) activation. On other hand, might suppress tumor formation TTV-derived apoptosis-inducing protein (TAIP) NF-κB signaling inhibition. The high prevalence patients could also be attributed to immunocompromised status rather than a direct causative viruses. underscores need for more comprehensive studies, including vitro vivo experiments, clarify progression.

Language: Английский

Gut virome in inflammatory bowel disease and beyond DOI Creative Commons
Hein M. Tun, Ye Peng, Luca Massimino

et al.

Gut, Journal Year: 2023, Volume and Issue: 73(2), P. 350 - 360

Published: Nov. 10, 2023

The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part microbiota. coexists with other components microbiota host in dynamic equilibrium, serving as key contributor to maintenance intestinal homeostasis functions. However, this equilibrium can be interrupted certain pathological states, including inflammatory bowel disease, causing dysbiosis that may participate disease pathogenesis. Nevertheless, whether causal or bystander event requires further clarification.

Language: Английский

Citations

27
Torque Teno Virus: Lights and Shades DOI Creative Commons
Paola Brani, Hafza Zahira Manzoor, Pietro Giorgio Spezia

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 334 - 334

Published: Feb. 27, 2025

Torque Teno Virus (TTV) is a highly prevalent non-pathogenic DNA virus whose plasma levels may be related to the host’s immune status. TTV gained attention about 25 years ago, but its replication not fully understood, nor relationship with host's system. Despite this lack of knowledge, currently being investigated as functional biomarker system in patients immunological damage and inflammatory diseases. Monitoring viral load over time help clinicians making therapeutic decisions regarding immunosuppression well likelihood infectious complications. This review summarizes what we do know enigmatic virus.

Language: Английский

Citations

0
Microbiota-associated mechanisms in colorectal cancer DOI

Adriana González,

Asier Fullaondo,

Adrián Odriozola

et al.

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 205

Published: Jan. 1, 2024

Language: Английский

Citations

2
Intratumoral microbiota in colorectal cancer: focus on specific distribution and potential mechanisms DOI Creative Commons
Jing Long, Jiamei Wang, Chong Xiao

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 26, 2024

Language: Английский

Citations

2
Anelloviruses and Cancer DOI Creative Commons

Jason Y Tang,

T. Chen, Valentina L. Kouznetsova

et al.

The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 231(2), P. 298 - 306

Published: Dec. 14, 2024

Anelloviruses are among the most prevalent viruses within human virome, detected in >90% of healthy individuals. Despite their ubiquity, role anelloviruses health remains elusive. This review examines potential associations torque teno virus (TTV), midi (TTMDV), and mini (TTMV) with various cancers, highlighting mixed conclusions from current epidemiological studies. may modulate cancer development through abnormal gene fusion, immune response, Toll-like receptor 9 (TLR9) activation. On other hand, might suppress tumor formation TTV-derived apoptosis-inducing protein (TAIP) NF-κB signaling inhibition. The high prevalence patients could also be attributed to immunocompromised status rather than a direct causative viruses. underscores need for more comprehensive studies, including vitro vivo experiments, clarify progression.

Language: Английский

Citations

0