Immune Response and Tumor Microenvironment DOI

Vivek Pazhamalai,

V. T. Thanush,

P. Dharshika

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 52

Published: Dec. 17, 2024

Tumor formation and progression are caused by neoplastic cells, which take advantage of interfere with cellular processes that control growth, survival, division. New research emphasizes the critical role tumor microenvironment (TME) in cancer initiation metastasis, even though genetic epigenetic changes well-known malignant transformation. The influences metagenesis, angiogenesis, immune tolerance, helps cells proliferate rapidly. It also plays a origin, progression, invasion cancer. With variety roles, including matrix deposition remodeling, extensive reciprocal signaling connections crosstalk invading leukocytes, cancer-associated fibroblasts (CAFs) an essential part microenvironment. This chapter reveals origins CAFs heterogeneity CAF function, wherein it is preferable to preserve some antitumorigenic properties.

Language: Английский

Multiple aspects of matrix stiffness in cancer progression DOI Creative Commons
Alessandro Mancini, Maria Teresa Gentile, Francesca Pentimalli

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 2, 2024

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in processes cell differentiation proliferation. However, it is unclear to what extent tumor cells influenced by changes surrounding microenvironment how this response varies between different forms, over course progression. entire ensemble genes encoding ECM associated proteins called matrisome. In cancer, evolves become highly dysregulated, rigid, fibrotic, serving both pro-tumorigenic anti-tumorigenic roles. Tumor desmoplasia characterized a dramatic increase α-smooth muscle actin expressing fibroblast deposition hard containing collagen, fibronectin, proteoglycans, hyaluronic acid common many solid tumors. review, we described role inflammation inflammatory cytokines, desmoplastic remodeling, state transition driven forces signaling pathways mechanotransduction as potential targeted therapies, focusing on impact qualitative quantitative variations regulation development, hypothesizing presence matrisome drivers, acting alongside cell-intrinsic oncogenic some stages neoplastic progression contexts, such pancreatic carcinoma, breast lung cancer mesothelioma.

Language: Английский

Citations

11
Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics DOI Creative Commons
Rasoul Mirzaei, Davide Campoccia, Stefano Ravaioli

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(2), P. 184 - 184

Published: Feb. 13, 2024

Bacterial biofilms, enigmatic communities of microorganisms enclosed in an extracellular matrix, still represent open challenge many clinical contexts, including orthopedics, where biofilm-associated bone and joint infections remain the main cause implant failure. This study explores scenario biofilm infections, with a focus on those related to orthopedic implants, highlighting recently emerged substantial aspects pathogenesis their potential repercussions clinic, as well progress gaps that exist diagnostics management these infections. The classic mechanisms through which biofilms form more proposed new ones are depicted. ways bacteria hide, become impenetrable antibiotics, evade immune defenses, creating reservoirs difficult detect reach, delineated, such bacterial dormancy within entry into host cells, penetration canaliculi. New findings formation components presented. article also delves emerging critical concept immunometabolism, key function cells interferes with. growing metabolomics diagnosis therapy is highlighted, referring latest research.

Language: Английский

Citations

8
Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance DOI Open Access

C. Raman Suri,

Babita Pande,

Lakkakula Suhasini Sahithi

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Language: Английский

Citations

1
The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer DOI Open Access
Marisabel Mecca,

Simona Picerno,

Salvatore Cortellino

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2750 - 2750

Published: Feb. 27, 2024

Inflammation is a key contributor to both the initiation and progression of tumors, it can be triggered by genetic instability within as well lifestyle dietary factors. The inflammatory response plays critical role in epigenetic reprogramming tumor cells, cells that comprise microenvironment. Cells microenvironment acquire phenotype promotes immune evasion, progression, metastasis. We will review mechanisms pathways involved interaction between inflammation, nutrition, limitations current therapies, discuss potential future therapeutic approaches.

Language: Английский

Citations

7
A Primer on Proteomic Characterization of Intercellular Communication in a Virus Microenvironment DOI Creative Commons
James Kostas,

Colter S Brainard,

Ileana M. Cristea

et al.

Molecular & Cellular Proteomics, Journal Year: 2025, Volume and Issue: unknown, P. 100913 - 100913

Published: Jan. 1, 2025

Language: Английский

Citations

0
Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors DOI Creative Commons
Tang‐Her Jaing, Yi-Wen Hsiao, Yi-Lun Wang

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 90 - 90

Published: Jan. 31, 2025

Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR

Language: Английский

Citations

0
The Mechanisms and Therapeutic Implications of Metabolic Communication in the Tumor-Immune Microenvironment DOI
Mahmoud Singer, Rania Hamdy,

Tasneem M. Elsayed

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metabolic Imbalance in Immune Cells in Relation to Metabolic Disorders, Cancer, and Infections DOI
Mahmoud Singer, Rania Hamdy,

Jana H. Ghonaim

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
An atlas of transcriptomic changes in human immune cells driven by 364 endogenous and gut-microbiota-derived metabolites DOI Creative Commons

Yiheng Zhao,

Yuhua Ma,

Huimin Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Metabolites, particularly those derived from gut microbiota, play crucial roles in modulating immune responses, but the impact of most metabolites on cells remains unexplored. To systematically investigate effect cells, we treated peripheral blood mononuclear (PBMCs) with 364 endogenous and microbiota analyzed their PBMC transcriptome using RNA sequencing (RNA-seq). Clustering analysis revealed three distinct metabolite groups (Cluster 0, 1, 2), each exerting unique immunomodulatory effects. Cluster 1 metabolites, enhanced inflammatory pathways (e.g., cytokine signaling, neutrophil migration) suppressed ferroptosis, potentially prolonging cell activity. In contrast, 0 promoted antigen presentation extracellular matrix repair, while 2 upregulated autophagy-related GTPase ubiquitin-protein regulation), suggesting anti-inflammatory tissue-homeostatic functions. Immune deconvolution highlighted 1-driven monocyte-to-M0 macrophage differentiation elevated activated dendritic/mast aligning pro-inflammatory outcomes. Metabolites Clusters 0/2 were enriched TCA cycle alanine/aspartate metabolism, whereas correlated beta-alanine branched-chain amino acid pathways. Gut identified 23 species overrepresented linking dysbiosis to profiles. Together, this high-throughput atlas elucidates how bloodborne shape function, offering insights into metabolic-immune crosstalk potential therapeutic targets for autoimmune disorders.

Language: Английский

Citations

0
Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment DOI Open Access
Durre Aden, Niti Sureka, Samreen Zaheer

et al.

Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

ABSTRACT Cancer is a complex and heterogeneous disease characterised by uncontrolled cell growth proliferation. One hallmark of cancer cells their ability to undergo metabolic reprogramming, which allows them sustain rapid survival. This reprogramming creates an immunosuppressive microenvironment that facilitates tumour progression evasion the immune system. In this article, we review mechanisms underlying in discuss how these alterations contribute establishment microenvironment. We also explore potential therapeutic strategies targeting vulnerabilities enhance immune‐mediated anti‐tumour responses. Trial Registration ClinicalTrials.gov identifier: NCT02044861, NCT03163667, NCT04265534, NCT02071927, NCT02903914, NCT03314935, NCT03361228, NCT03048500, NCT03311308, NCT03800602, NCT04414540, NCT02771626, NCT03994744, NCT03229278, NCT04899921

Language: Английский

Citations

2