Metallacarboranes in Medicinal Chemistry: Current Advances and Future Perspectives

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(11), P. 8481 - 8501

Published: May 21, 2024

Metallacarboranes, exemplified by cobalt bis(dicarbollide) ([COSAN]−), have excelled their historical metallocene analogue label to become promising in drug design, medical studies, and fundamental biological research. Serving as a unique platform for conjugation with biomolecules, they also constitute an auspicious building block biologically active derivatives carrier cellular transport of membrane-impermeable cargos. Modified [COSAN]− exhibits specific antimicrobial, antiviral, anticancer actions showing promise preclinical trials. Contributing the ongoing development medicinal chemistry, metallacarboranes offer desirable physicochemical properties low acute toxicity. This article presents critical look at context application emphasizing potential game-changer design biomedical sciences. As chemistry seeks innovative blocks, emerge important novelty versatile solutions implications.

Language: Английский

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Carborane in Polymers—Existent Stipulations and Technological Trademarks

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: Feb. 10, 2025

Language: Английский

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Enhancing Boron Neutron Capture Therapy (BNCT) with Materials Based on COSAN-Functionalized Nanoparticles

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 466 - 466

Published: March 26, 2025

Background/Objectives: Boron neutron capture therapy (BNCT) is a promising approach for selectively targeting and destroying malignant cells using 10B isotopes. A significant challenge in BNCT lies the development of efficient boron delivery systems that ensure adequate accumulation within tumor cells. This study aims to synthesize, characterize, evaluate COSAN-functionalized nanoparticles (NP@I-COSAN) as potential carrier BNCT. Methods: Hybrid were synthesized by conjugating monoiodinated cobaltabisdicarbollides (I-COSAN) commercially available acrylic polymer-based nanoparticles. Functionalization cellular uptake confirmed through FTIR, TGA, UV-Vis spectroscopy, TEM/EDX analyses. Biocompatibility was evaluated assessing cytotoxicity HeLa C. elegans an vivo model. Intracellular quantified ICP-MS, with results compared those obtained 4-borono-L-phenylalanine conjugated fructose (f-BPA). An vitro proof-of-concept assay also performed therapeutic efficacy. Results: NP@I-COSAN demonstrated low internalization ICP-MS analysis revealed stable retention, comparable traditional agents. The further showed effective inducing cell apoptosis, even at lower concentrations than conventional treatments. Conclusions: These underscore system BNCT, offering strategy enhance improve treatment

Language: Английский

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Cyclodextrin Mediated Non-Aqueous Electrophoresis for Chiral Separations of Anionic Boron Clusters

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128117 - 128117

Published: April 1, 2025

Language: Английский

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Ferrocenyl carborane conjugates with allyl functionalities: Synthesis and properties

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1008, P. 123062 - 123062

Published: Feb. 15, 2024

Language: Английский

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A Pd-catalyzed route to carborane-fused boron heterocycles

Chemical Science, Journal Year: 2024, Volume and Issue: 15(27), P. 10392 - 10401

Published: Jan. 1, 2024

A Pd-catalyzed cross-coupling system has been developed to achieve vicinal diamination of 9,10-dibromo-carborane with NH-heterocycles and anilines. These products can be further converted carborane-fused six- seven-membered heterocycles.

Language: Английский

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Synthesis of novel zwitterionic nido-carborane-containing derivatives of cysteine and methionine

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(6), P. 1716 - 1724

Published: June 1, 2024

Language: Английский

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Compelling DNA intercalation through ‘anion–anion’ anti-coulombic interactions: boron cluster self-vehicles as promising anticancer agents

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(38), P. 9550 - 9565

Published: Jan. 1, 2024

The amphiphilic anionic ferrabis(dicarbollide) boron-rich small molecule effectively penetrates the nucleus as a carrier-free drug and intercalates with ds-DNA base pairs, making it promising candidate for multimodal cancer radiotherapy.

Language: Английский

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Synthesis of Novel Planar-Chiral Charge-Compensated nido-Carborane-Based Amino Acid

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4487 - 4487

Published: Sept. 21, 2024

Amino acids with unusual types of chirality and their derivatives have recently attracted attention as precursors in the synthesis chiral catalysts peptide analogues unique properties. In this study, we synthesized a new nido-carborane-based planar-chiral amino acid, molecule which group is directly bonded to B(3) atom, carboxyl attached B(9) atom through CH2S+(Me) fragment. 3-Amino-9-dimethylsulfonio-nido-carborane, prepared three steps from 3-amino-closo-carborane high yield, was key intermediate target acid. The carboxymethyl at sulfur introduced by demethylation reaction dimethylsulfonio derivative, followed S-alkylation. structure 3,9-disubstituted nido-carboranes studied for first time using NMR spectroscopy. resonances all boron atoms 11B spectrum 3-amino-9-dimethylsulfonio-nido-carborane were assigned based on 2D correlation experiments. acid related compounds are interest basis peptide-like ligands.

Language: Английский

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A novel quantitative method for the determination of 10B-carrier boronophenylalanine in rat plasma by UHPLC-MS/MS and comparison with ICP-MS

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 253, P. 116538 - 116538

Published: Oct. 20, 2024

Language: Английский

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