Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 10, 2024
Abstract
Background
Despite
the
higher
sensitivity
of
melanoma
towards
ferroptosis
and
photodynamic
therapy
(PDT),
lack
efficient
inducers
poor
solubility
photosensitizers
restrict
their
synergistic
strategies.
With
unique
advantages,
carbon
dots
(CDs)
are
expected
to
serve
as
innovative
building
blocks
for
combination
cancers.
Results
Herein,
an
ferroptosis/PDT
integrated
nanoplatform
is
constructed
based
on
chlorin
e6-modified
Fe
ions-doped
(Fe-CDs@Ce6).
As
novel
type
iron-carbon
hybrid
nanoparticles,
as-prepared
Fe-CDs
can
selectively
activate
ferroptosis,
prevent
angiogenesis
inhibit
migration
mouse
skin
cells
(B16),
but
have
no
toxicity
normal
cells.
The
nano-conjugated
structures
facilitate
not
only
aqueous
dispersibility
Ce6,
also
self-accumulation
ability
Fe-CDs@Ce6
within
area
without
requiring
extra
targets.
Moreover,
therapeutic
effects
synergistically
enhanced
due
increased
GSH
depletion
by
PDT
elevated
singlet
oxygen
(
1
O
2
)
production
efficiency
Fe-CDs.
When
combined
with
laser
irradiation,
tumor
growth
be
significantly
suppressed
through
cyclic
administration.
T
-weighted
magnetic
resonance
imaging
(MRI)
capability
reveals
potentials
cancer
diagnosis
navigation
therapy.
Conclusions
Our
findings
indicate
multifunctionality
in
effectively
combining
therapy,
targeting
MRI
imaging,
which
enables
become
promising
biocompatible
treatment
melanoma.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 2485 - 2529
Published: June 1, 2024
Abstract:
Ferroptosis,
a
unique
form
of
programmed
cell
death,
is
initiated
by
an
excess
iron
accumulation
and
lipid
peroxidation-induced
damage.
There
growing
body
evidence
indicating
that
ferroptosis
plays
critical
role
in
the
advancement
tumors.
The
increased
metabolic
activity
higher
levels
tumor
cells
make
them
particularly
vulnerable
to
ferroptosis.
As
result,
targeted
induction
becoming
increasingly
promising
approach
for
cancer
treatment.
This
review
offers
overview
regulatory
mechanisms
ferroptosis,
delves
into
mechanism
action
traditional
small
molecule
inducers
their
effects
on
various
In
addition,
latest
progress
inducing
using
new
means
such
as
proteolysis-targeting
chimeras
(PROTACs),
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
nanomaterials
summarized.
Finally,
this
discusses
challenges
opportunities
development
ferroptosis-inducing
agents,
focusing
discovering
targets,
improving
selectivity,
reducing
toxic
side
effects.
Keywords:
inducers,
molecules,
PROTACs,
PDT,
SDT,
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 648 - 648
Published: April 8, 2024
Nanodynamic
therapy
(NDT)
exerts
its
anti-tumor
effect
by
activating
nanosensitizers
to
generate
large
amounts
of
reactive
oxygen
species
(ROS)
in
tumor
cells.
NDT
enhances
tumor-specific
targeting
and
selectivity
leveraging
the
microenvironment
(TME)
mechanisms
that
boost
immune
responses.
It
also
minimizes
damage
surrounding
healthy
tissues
cytotoxicity
cells,
showing
promise
cancer
treatment,
with
significant
potential.
This
review
covers
research
progress
five
major
nanodynamic
therapies:
photodynamic
(PDT),
electrodynamic
(EDT),
sonodynamic
(SDT),
radiodynamic
(RDT),
chemodynamic
(CDT),
emphasizing
role
advanced
nanotechnology
development
for
purposes.
The
mechanisms,
effects,
challenges
faced
these
NDTs
are
discussed,
along
their
respective
solutions
enhancing
efficacy,
such
as
pH
response,
delivery,
combined
immunotherapy.
Finally,
this
briefly
addresses
clinical
translation
NDT.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Over
the
past
two
decades,
iron-based
metal-organic
frameworks
(Fe-MOFs)
have
attracted
significant
research
interest
in
biomedicine
due
to
their
low
toxicity,
tunable
degradability,
substantial
drug
loading
capacity,
versatile
structures,
and
multimodal
functionalities.
Despite
great
potential,
transition
of
Fe-MOFs-based
composites
from
laboratory
clinical
products
remains
challenging.
This
review
evaluates
key
properties
that
distinguish
Fe-MOFs
other
MOFs
highlights
recent
advances
synthesis
routes,
surface
engineering,
shaping
technologies.
In
particular,
it
focuses
on
applications
biosensing,
antimicrobial,
anticancer
therapies.
addition,
emphasizes
need
develop
scalable,
environmentally
friendly,
cost-effective
production
methods
for
additional
meet
specific
requirements
various
biomedical
applications.
ability
combine
therapies,
hurdles
still
remain,
including
a
deeper
understanding
therapeutic
mechanisms
potential
risks
resistance
overdose.
Systematically
addressing
these
challenges
could
significantly
enhance
prospects
potentially
facilitate
integration
into
mainstream
practice.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 10, 2024
Abstract
Background
Despite
the
higher
sensitivity
of
melanoma
towards
ferroptosis
and
photodynamic
therapy
(PDT),
lack
efficient
inducers
poor
solubility
photosensitizers
restrict
their
synergistic
strategies.
With
unique
advantages,
carbon
dots
(CDs)
are
expected
to
serve
as
innovative
building
blocks
for
combination
cancers.
Results
Herein,
an
ferroptosis/PDT
integrated
nanoplatform
is
constructed
based
on
chlorin
e6-modified
Fe
ions-doped
(Fe-CDs@Ce6).
As
a
novel
type
iron-carbon
hybrid
nanoparticles,
as-prepared
Fe-CDs
can
selectively
activate
ferroptosis,
prevent
angiogenesis
inhibit
migration
mouse
skin
cells
(B16),
but
have
no
toxicity
normal
cells.
The
nano-conjugated
structures
facilitate
not
only
aqueous
dispersibility
Ce6,
also
self-accumulation
ability
Fe-CDs@Ce6
within
area
without
requiring
extra
targets.
Moreover,
therapeutic
effects
synergistically
enhanced
due
increased
GSH
depletion
by
PDT
elevated
singlet
oxygen
(
1
O
2
)
production
efficiency
Fe-CDs.
When
combined
with
laser
irradiation,
tumor
growth
be
significantly
suppressed
through
cyclic
administration.
T
-weighted
magnetic
resonance
imaging
(MRI)
capability
reveals
potentials
cancer
diagnosis
navigation
therapy.
Conclusions
Our
findings
indicate
multifunctionality
in
effectively
combining
therapy,
targeting
MRI
imaging,
which
enables
become
promising
biocompatible
treatment
melanoma.
Graphic
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 5, 2024
The
curative
effect
of
single
therapy
for
advanced
cholangiocarcinoma
(CCA)
is
poor,
thus
investigating
combined
treatment
strategies
holds
promise
improving
prognosis.
Surufatinib
(SUR)
a
novel
multikinase
inhibitor
that
has
been
confirmed
to
prolong
survival
patients
with
CCA.
Photodynamic
(PDT)
can
also
ablate
CCA
and
relieve
biliary
obstruction.
In
this
study,
we
explored
the
anti-CCA
SUR
PDT,
underlying
mechanism.
We
found
could
effectively
inhibit
abilities
proliferation,
migration
metastasis
in
cells
(HUCCT-1,
RBE).
ability
was
by
HUCCT-1
cell
xenograft
model
Balb/c
nude
mice
patient-derived
organoids.
PDT
significantly
enhance
inhibitory
on
CCA,
be
alleviated
two
ferroptosis
inhibitors
(Ferrostatin-1,
Deferoxamine).
By
detecting
level
reactive
oxygen
species,
lipid
peroxides,
malondialdehyde
glutathione,
further
inducing
ferroptosis.
Glutathione
peroxidase
4
(GPX4)
belongs
glutathione
family
mainly
responsible
metabolism
intracellular
hydrogen
peroxide.
GPX4
inhibits
reducing
cytotoxic
peroxides
(L-OOH)
corresponding
alcohols
(L-OH).
Acyl-CoA
synthetase
long-chain
member
(ACSL4)
fatty
acid
coenzyme
involved
biosynthesis
catabolism
acids.
ACSL4
induces
promoting
accumulation
peroxides.
Both
induce
inhibiting
GPX4.
regulation
more
significant
group.
conclusion,
exerted
an
Combination
provides
new
idea
clinical
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: Aug. 12, 2024
Ferroptosis
is
an
iron-dependent
form
of
cell
death
that
results
from
excess
lipid
peroxidation
in
cellular
membranes.
Within
the
last
decade,
physiological
and
pathological
roles
for
ferroptosis
have
been
uncovered
autoimmune
diseases,
inflammatory
conditions,
infection,
cancer
biology.
Excitingly,
metabolism
may
be
targeted
to
induce
by
cancers
are
resistant
other
forms
death.
sensitivity
regulated
oxidative
stress,
metabolism,
iron
which
all
influenced
tumor
microenvironment
(TME).
Whereas
some
types
shown
adapt
these
stressors,
it
not
clear
how
immune
cells
regulate
their
sensitivities
ferroptosis.
In
this
review,
we
discuss
mechanisms
different
subsets,
influences
infiltrate
TME,
interactions
can
determine
epithelial-to-mesenchymal
transition
(EMT)
metastasis.
While
much
focus
has
placed
on
inducing
cells,
important
considerations
ferroptosis-modulating
strategies
impact
anti-tumor
immunity.
From
perspective,
also
promising
immunotherapies
field
challenges
associated
with
targeting
specific
populations.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1437 - 1437
Published: Feb. 8, 2025
Photodynamic
therapy
(PDT)
involves
the
use
of
photosensitizers
(PSs)
that,
upon
activation
by
specific
wavelengths
light,
generate
reactive
oxygen
species
(ROS),
including
singlet
(1O2)
and
hydroxyl
radicals
(·OH),
within
targeted
tissue,
typically
tumor
cells.
The
generated
ROS
induces
cellular
damage,
disrupts
processes,
ultimately
leads
to
apoptosis
or
necrosis
However,
clinical
application
PDT
is
significantly
hindered
limited
tissue
penetration
ability
light.
To
address
this
limitation,
laser-free
self-luminescent
photosensitive
systems
have
emerged
as
potential
solutions
for
achieving
deep-tissue
imaging.
This
review
provides
a
comprehensive
analysis
various
laser-independent
systems,
with
particular
emphasis
on
those
based
resonance
energy
transfer
(RET),
chemically
induced
electron
exchange
luminescence
(CIEEL),
Cherenkov
radiation
(CRET).
aim
offer
theoretical
framework
development
novel
photodynamic
reassess
certain
previously
overlooked
(PSs).
Future Science OA,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Feb. 10, 2025
Glioblastoma,
an
aggressive
brain
cancer,
has
limited
treatment
options
and
poor
prognosis.
Taiwanese
green
propolis,
known
for
its
tumor-inhibitory
properties,
shows
promise
when
combined
with
photodynamic
therapy
(PDT),
a
targeted,
low-toxicity
treatment.
This
study
investigated
novel
propolis-based
compound
inducing
apoptosis
in
glioblastoma
cells
synergistic
potential
daylight
PDT.
Ethanol
extracts
of
wheatgrass,
mulberry
leaves
were
analyzed
using
High-Performance
Liquid
Chromatography
(HPLC).
Apoptosis
induction
U87
was
assessed
via
the
MTT
assay
following
alone
combination
PDT
at
570
nm.
We
identified
Artepillin
C
as
main
active
component
by
HPLC,
which
significantly
induced
cells.
Combined
PDT,
it
demonstrated
enhanced
efficacy,
cell
viability
reduced
from
95.2%
0.25
µL
to
11.3%
8
extract.
The
EC50
decreased,
indicating
greater
apoptotic
activity
compared
extract
alone.
provides
first
vitro
evidence
anti-tumor
effects
(GPDT),
highlighting
promising
therapeutic
approach
that
warrants
further
clinical
investigation.
