Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

et al.

Creative Surgery and Oncology, Journal Year: 2024, Volume and Issue: 14(4), P. 369 - 381

Published: Dec. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Language: Английский

Mechanism of Notch Signaling Pathway in Malignant Progression of Glioblastoma and Targeted Therapy DOI Creative Commons
Shenghao Wang,

Sikuan Gu,

Junfan Chen

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 480 - 480

Published: April 15, 2024

Glioblastoma multiforme (GBM) is the most aggressive form of glioma and common primary tumor central nervous system. Despite significant advances in clinical management strategies diagnostic techniques for GBM recent years, it remains a fatal disease. The current standard care includes surgery, radiation, chemotherapy, but five-year survival rate patients less than 5%. search more precise diagnosis earlier intervention critical urgent challenge practice. Notch signaling pathway system that has been extensively studied malignant progression glioblastoma. This highly conserved cascade to variety biological processes, including growth, proliferation, self-renewal, migration, apoptosis, metabolism. In GBM, accumulating data suggest hyperactive contributes initiation, progression, treatment resistance. review summarizes functions molecular mechanisms as well some targeting cancer glioblastoma, highlighting its potential focus novel therapeutic strategies.

Language: Английский

Citations

5
Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review DOI Open Access
Emir Begagić, Hakija Bečulić,

Amina Džidić-Krivić

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 2089 - 2089

Published: May 30, 2024

Background: The study aims to investigate the role of hypoxia-inducible factors (HIFs) in development, progression, and therapeutic potential glioblastomas. Methodology: study, following PRISMA guidelines, systematically examined hypoxia HIFs glioblastoma using MEDLINE (PubMed), Web Science, Scopus. A total 104 relevant studies underwent data extraction. Results: Among studies, global contributions were diverse, with China leading at 23.1%. most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) frequently studied, followed by 2 (HIF2α), osteopontin, cavolin-1. Commonly associated pathways include glucose transporter (GLUT1) 3 (GLUT3) receptors, vascular endothelial growth (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target rapamycin (mTOR) pathway, reactive oxygen species (ROS). HIF expression correlates various hallmarks, including survival, neovascularization, metabolism, migration, invasion. Conclusion: Overcoming challenges such as treatment resistance absence biomarkers is critical effective integration HIF-related therapies into aim optimizing patient outcomes.

Language: Английский

Citations

5
Molecular Mechanisms and Strategies for Inducing Neuronal Differentiation in Glioblastoma Cells DOI

Zhao-Qi Tang,

Yan-Rong Ye,

Yun Shen

et al.

Cellular Reprogramming, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Glioblastoma multiforme (GBM) is a highly invasive brain tumor, and traditional treatments combining surgery with radiochemotherapy have limited effects, tumor recurrence being almost inevitable. Given the lack of proliferative capacity in neurons, inducing terminal differentiation GBM cells or glioma stem (GSCs) into neuron-like has emerged as promising strategy. This approach aims to suppress their proliferation self-renewal capabilities through differentiation. review summarizes methods involved recent research on neuronal GSCs, including regulation transcription factors, signaling pathways, miRNA, use small molecule drugs, among various strategies. It also outlines interconnections between mechanisms studied, hoping provide ideas for exploring new therapeutic avenues development differentiation-inducing drugs GBM.

Language: Английский

Citations

0
Prospects of marine-derived compounds as potential therapeutic agents for glioma DOI Creative Commons
Ying Liu, Zhiyang Zhou, Shusen Sun

et al.

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 513 - 526

Published: June 12, 2024

Glioma, the most common primary malignant brain tumour, is a grave health concern associated with high morbidity and mortality. Current treatments, while effective to some extent, are often hindered by factors such as blood-brain barrier tumour microenvironment. This underscores pressing need for exploring new pharmacologically active anti-glioma compounds.

Language: Английский

Citations

2
Role of autophagy in modulating tumor cell radiosensitivity: Exploring pharmacological interventions for glioblastoma multiforme treatment DOI Creative Commons

Pierre Bischoff,

Jolie Bou-Gharios, G. Noël

et al.

Cancer/Radiothérapie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0
PLGA‐Loaded Nedaplatin (PLGA‐NDP) Inhibits 7,12‐Dimethylbenz[a]anthracene (DMBA) Induced Oral Carcinogenesis via Modulating Notch Signaling Pathway and Induces Apoptosis in Experimental Hamster Model DOI Open Access
Senkuttuvan Ilanchit Chenni, Suresh Kathiresan,

Azhamuthu Theerthu

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(7)

Published: Oct. 1, 2024

The present study is designed to evaluate the nanotherapeutic efficacy of prepared PLGA-loaded Nedaplatin (PLGA-NDP) against 7,12-dimethyl benz(a)anthracene (DMBA)-induced experimental oral carcinogenesis in hamster buccal pouch (HBP) model. golden Syrian hamsters was painted with 0.5% DMBA liquid paraffin three times a week for 14 weeks, ultimately leading development squamous cell carcinoma (OSCC). Oral administration PLGA-NDP (preinitiation) and Cisplatin delivery (5 mg/kg b.wt) started 1 before carcinogen exposure continued on alternative days. Post-administration 2 days after (DMBA) induction until end experiment. After 14th week, we observed that DMBA-painted exhibited tumor formation, morphological alterations, well-differentiated OSSC addition responsive molecular proteins during carcinogenesis. Furthermore, immunoblotting analysis demonstrated inhibits Notch signaling, as evidenced by downregulation Bcl-Xl, Bcl-2, p21, PGE2, HGF, CXCL12 proteins, upregulation p53 Bax. This apoptotic response crucial induce apoptosis. In addition, RT-PCR results showed nanoparticles play downregulatory role therapeutic action notch signaling gene (Notch1, 2, Hes1, Hey1, Jagged1) at mRNA transcription level HBP carcinoma. Taken together, these data indicate potent inhibitor expansion cells specifically target pathway indicates obstructing could potentially serve new innovative approach

Language: Английский

Citations

0
The Role of PDCD6 in Stemness Maintenance of Glioblastoma DOI
Xiyu Liu,

Zi-Jian Shi,

Xuantong Liu

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 264, P. 155727 - 155727

Published: Nov. 16, 2024

Language: Английский

Citations

0
Optimized Binary and Multi-Class Classification With Biomarker Detection in Brain Cancer Gene Expression DOI

Abioye Abiodun Oluwasegun,

Olalekan J. Awujoola, Muhammad Nazeer Musa

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 315 - 360

Published: Dec. 17, 2024

This chapter presents a comprehensive analysis of brain cancer gene expression datasets through binary and multi-class classification using the CatBoostClassifier, enhanced by Principal Component Analysis (PCA) for dimensionality reduction. The result discussion section elucidates key findings, trends, efficacy methodologies employed. Utilizing Volcano Plots, we identified significant biomarkers that differentiate between cancerous normal tissues, facilitating discovery potential diagnostic targets. In classification, model effectively distinguished various types, including ependymoma, glioblastoma, medulloblastoma, pilocytic astrocytoma, achieving an overall accuracy 87%. Conversely, exhibited remarkable performance, attaining 100% accuracy, precision, recall, F1-score in distinguishing tumors from samples. underscores machine learning techniques advancing diagnostics improving patient outcomes.

Language: Английский

Citations

0
Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

et al.

Creative Surgery and Oncology, Journal Year: 2024, Volume and Issue: 14(4), P. 369 - 381

Published: Dec. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Language: Английский

Citations

0