Identification of a circadian-based prognostic signature predicting cancer-associated fibroblasts infiltration and immunotherapy response in bladder cancer DOI Creative Commons
Li Zhou, Jiaming He, Zhiming Hu

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Circadian rhythm disruption impacts the efficiency of both chemotherapy and immunotherapy, yet identifying key factors involved remains challenging. can trigger aberrant fibroblasts activation, suggesting potential roles cancer-associated (CAFs) in addressing this issue. In paper, TCGA-BLCA patients were classified into two subgroups based on expression core circadian genes (CCRGs). The CCRG-based showed distinct fibroblast-related signals, from which a risk model composed five was finally established with excellent survival prognostic value TCGA GEO datasets. positively associated infiltration CAFs efficiently predict immunotherapy response BLCA. Besides, high-risk score reduced sensitivity to majority traditional chemotherapeutic drugs such as oxaliplatin gemcitabine. Further, correlation between CCRGs analyzed. Among genes,

Language: Английский

Protein-Based Predictive Biomarkers to Personalize Neoadjuvant Therapy for Bladder Cancer—A Systematic Review of the Current Status DOI Open Access
Stacy R. Bedore,

Joshua van der Eerden,

Faizan Boghani

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9899 - 9899

Published: Sept. 13, 2024

The clinical outcome of patients with muscle-invasive bladder cancer (MIBC) is poor despite the approval neoadjuvant chemotherapy or immunotherapy to improve overall survival after cystectomy. MIBC subtypes, immune, transcriptome, metabolomic signatures, and mutation burden have potential predict treatment response but none been incorporated into practice, as tumor heterogeneity lineage plasticity influence their efficacy. Using PRISMA statement, we conducted a systematic review literature, involving 135 studies published within last five years, identify reporting on prognostic value protein-based biomarkers for therapy in MIBC. were grouped based related molecular stem cell, actin-cytoskeleton, epithelial–mesenchymal transition, apoptosis, tumor-infiltrating immune cells. These show biomarkers, especially spatial context, reduce biomarker’s capability. Nevertheless, currently, there little consensus methodology, reagents, scoring systems allow reliable assessment interest. Furthermore, small sample size several necessitates validation larger multicenter cohorts before use individualizing regimens

Language: Английский

Citations

3

Contemporary Molecular Markers for Predicting Systemic Treatment Response in Urothelial Bladder Cancer: A Narrative Review DOI Open Access
George Dimitrov, Radoslav Mangaldzhiev,

Chavdar Slavov

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3056 - 3056

Published: Sept. 1, 2024

The search for dependable molecular biomarkers to enhance routine clinical practice is a compelling challenge across all oncology fields. Urothelial bladder carcinoma, known its significant heterogeneity, presents difficulties in predicting responses systemic therapies and outcomes post-radical cystectomy. Recent advancements cancer biology offer promising avenues understand the disease's identify emerging predictive biomarkers. Stratifying patients based on their recurrence risk post-curative treatment or efficacy of conventional targeted could catalyze personalized selection disease surveillance. Despite progress, reliable forecast agents, neoadjuvant, adjuvant, palliative settings, are still lacking, underscoring an urgent unmet need. This review aims delve into utilization current signatures various stages urothelial carcinoma predict therapy.

Language: Английский

Citations

0

Role of Neoadjuvant Immunotherapy in Genitourinary Malignancies DOI Open Access
Adam Khorasanchi, Karan Jatwani, Lingbin Meng

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4127 - 4127

Published: Dec. 10, 2024

Genitourinary (GU) malignancies are common and associated with significant morbidity mortality. In patients localized GU cancers, surgical resection or definitive radiation remain the mainstays of treatment. Despite treatment, many high-risk disease experience recurrence. There is growing interest in using neoadjuvant immunotherapy to improve outcomes. This narrative review summarizes current evidence for cancers including renal cell carcinoma, urothelial prostate cancer, penile squamous testicular germ tumors. We also discuss ongoing clinical trials candidate biomarkers optimize patient selection treatment

Language: Английский

Citations

0

CTLA4 genetic variants associated with urothelial bladder cancer susceptibility DOI
Alexsandro Koike, Andréa Name Colado Simão, Tainah Mendes Ahrens

et al.

Urologic Oncology Seminars and Original Investigations, Journal Year: 2024, Volume and Issue: 42(11), P. 374.e1 - 374.e10

Published: June 15, 2024

Language: Английский

Citations

0

Identification of a circadian-based prognostic signature predicting cancer-associated fibroblasts infiltration and immunotherapy response in bladder cancer DOI Creative Commons
Li Zhou, Jiaming He, Zhiming Hu

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Circadian rhythm disruption impacts the efficiency of both chemotherapy and immunotherapy, yet identifying key factors involved remains challenging. can trigger aberrant fibroblasts activation, suggesting potential roles cancer-associated (CAFs) in addressing this issue. In paper, TCGA-BLCA patients were classified into two subgroups based on expression core circadian genes (CCRGs). The CCRG-based showed distinct fibroblast-related signals, from which a risk model composed five was finally established with excellent survival prognostic value TCGA GEO datasets. positively associated infiltration CAFs efficiently predict immunotherapy response BLCA. Besides, high-risk score reduced sensitivity to majority traditional chemotherapeutic drugs such as oxaliplatin gemcitabine. Further, correlation between CCRGs analyzed. Among genes,

Language: Английский

Citations

0