Role of natural products in tumor therapy from basic research and clinical perspectives

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)

Published: Jan. 1, 2024

Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Synergistic Inhibition of Breast Carcinoma Cell Proliferation by Quercetin and Sulforaphane via Activation of the ERK/MAPK Pathway

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

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Impact of Sulforaphane on Breast Cancer Progression and Radiation Therapy Outcomes: A Systematic Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Breast cancer is a debilitating chronic condition that affects millions and causes the death of hundreds thousands people annually worldwide. Sulforaphane (SFN) has potential to prevent enhance management breast alleviate its poor outcomes. As most available evidence on SFN's impact safety in from cell culture studies animal models, there need consolidate this determine whether conduct empirical human studies. This systematic review summarizes analyzes progression radiation therapy outcomes terms efficacy safety. A literature search was performed PubMed, Cumulated Index Nursing Allied Health Literature, ProQuest Central, ScienceDirect databases find sources evidence. The selected were published between 2018 2024. inclusion exclusion criteria included last eight years, availability full-text, English, covering concepts relevant topic. summarized through tables synthesized identify themes SFN In total, 20 evidence, including three randomized controlled trials, five vivo 12 studies, for analysis. broadly classified into two themes, namely, role biology therapy. confirmed targets by modulating reactive oxygen species reducing proliferation tumors, inducing apoptosis, inhibiting metastasis. an effective safer treatment as it reduces damage protects normal cells, synergistic effect rather than interacting with other concentrations ranging 5 µM 200 µM. Cell models have proven highly prevention either single intervention or combination radiotherapy chemotherapy.

Language: Английский

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The anti-cancer effectiveness of some heterocyclic compounds containing sulfur atom

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102182 - 102182

Published: March 1, 2025

Language: Английский

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Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111743 - 111743

Published: March 1, 2025

Language: Английский

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Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications—A Comprehensive Review

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Phytochemicals are bioactive compounds found in plants that play a key role promoting health and preventing diseases. Present fruits, vegetables, grains, seed oils, these considered safe for consumption due to the co‐evolution adaptation between mammals plants. Due their wide‐ranging biological effects, they have attracted considerable research interest. This comprehensive review explores mechanisms of action, benefits, applications dietary phytochemicals, with particular focus on groups such as polyphenols, flavonoids, carotenoids. Research shows phytochemicals interact nuclear membrane receptors, influence metabolic pathways, affect epigenetic modifications. Our highlights broad range activities compounds, including antioxidant, antibacterial, anti‐inflammatory, anti‐diabetic, anticancer all which contribute health‐promoting properties. Clinical evidence supports prevention management diseases cardiovascular disorders, conditions, cancer, diets rich being linked lower risk disease. also at cutting edge food preservation, supplements, emerging medical treatments. Additionally, we identified advancements extraction identification techniques, particularly metabolomics, further enhance areas. Despite promising challenges bioavailability, regulatory barriers, need robust clinical trials persist. However, innovative delivery systems like nanoparticles, liposomes, encapsulation offer potential solutions bioavailability by improving absorption stability. The concludes emphasizing personalized nutrition combination therapies benefits while stressing methods, trials, bioavailability.

Language: Английский

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Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

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Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 29, 2024

Background Pancreatic cancer (PC), sometimes referred to as pancreatic ductal adenocarcinoma (PDAC), is a major cause of global mortality from cancer. very aggressive and devastating kind cancer, characterized by limited options for therapy low possibilities survival. Sulforaphane (SFN), naturally occurring sulfur-containing compound, believed possess anti-inflammatory, anti-obesity, anti-cancer characteristics. Objective However, efficient preventative treatment measures are essential SFN has been studied its ability suppress cell proliferation induce apoptosis. Methods Here, induced cytotoxicity apoptosis in PDAC lines such MIA PaCa-2 PANC-1 cells, evaluated cytotoxicity, colony formation, western blot analysis, fluorescence-activated sorting (FACS), reactive oxygen species (ROS) detection, caspase-3 activity assay, immunofluorescence mitochondrial membrane potential assay. Results In inhibited survival dose-dependent manner. The activation caspase zymogens results cleaved PARP caspase-3, which associated with an accumulation the sub G1 phase. Furthermore, increased ROS level γH2A.X expression while decreasing (ΔΨm). Notably, scavenger N-Acetyl-L-cysteine (NAC) was shown reverse SFN-induced level. Subsequently, cycle arrest induction Trojan horse eliminate cells via ROS-mediated pathways were used inhibit cells. Conclusion Collectively, our data demonstrates that death follows pathway, making it viable target therapeutic interventions against

Language: Английский

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Green HPLC Enantioseparation of Chemopreventive Chiral Isothiocyanates Homologs on an Immobilized Chiral Stationary Phase Based on Amylose tris-[(S)-α-Methylbenzylcarbamate]

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2895 - 2895

Published: June 18, 2024

Sulforaphane is a chiral phytochemical with chemopreventive properties. The presence of stereogenic sulfur atom responsible for the chirality natural isothiocyanate. key role in biological activity underscored by studies efficacy individual enantiomers as chemoprotective agents. predominant native (R) enantiomer active, whereas (S) antipode inactive or has little no activity. Here we provide an enantioselective high-performance liquid chromatography (HPLC) protocol direct and complete resolution sulforaphane its homologs different aliphatic chain lengths between sulfinyl isothiocyanate group, namely iberin, alyssin, hesperin. chromatographic separations were carried out on immobilized-type CHIRALPAK IH-3 stationary phase amylose tris-[(S)-methylbenzylcarbamate] selector. effects mobile phases consisting pure alcoholic solvents hydroalcoholic mixtures retention enantioselectivity carefully investigated. Simple environmentally friendly conditions all ITCs found. In particular, ethanol highly aqueous gave excellent enantioseparations. factors recorded water content aqueous-organic modifier (methanol, ethanol, acetonitrile) progressively varied. U-shaped maps generated, indicating dual competitive hydrophilic interaction (HILIC) reversed-phase mechanism phase. Finally, experimental chiroptical performed solution showed that eluted before counterpart under eluent

Language: Английский

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