Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 214 - 214

Published: Feb. 16, 2024

Breast cancer (BC) significantly impacts the quality of life (QoL) affected individuals. This study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess impact organ failures and metastases on QoL in breast patients using EORTC QLQ-C30 QLQ-BR45 questionnaires survival rate understand clinical journey status patients. From January 2019 October 2022, a prospective, observational study surveyed 874 patients, revealing 201 fatalities, 66 refusals, 607 eligible participants. Results indicated statistically significant differences various aspects for experiencing heart failure, including physical functioning, pain, insomnia, global health status, overall summary score. Kidney failure exhibited significance functioning body image, sexual endocrine symptoms QLQ-BR45. Respiratory demonstrated across multiple domains. Patients with bone reported lower (p = 0.006) increased pain 0.002). has revealed an 5-year expectancy 68.8%, rates 93.8% Stage I, 86.3% II, 77.2% III cancer. Metastatic have shown 35.6% over 45 months, median duration 36 months. A limitation our was administration questionnaire only once, preventing us from quantifying specific treatment types life. emphasizes necessity standardized assessments practice initial presentation ongoing follow-up.

Language: Английский

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The Impact on Survival of Neoadjuvant Treatment Interruptions in Locally Advanced Rectal Cancer Patients

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 266 - 266

Published: Feb. 29, 2024

The standard oncologic treatment of locally advanced rectal cancer is long-course radio-chemotherapy followed by surgery and adjuvant chemotherapy. This can result in a lengthy total duration, sometimes up to one year from the diagnosis. Interruptions neoadjuvant occur for variety reasons, forced or unforced. main purpose this study analyze survival data patients who received find cut-off point showing exactly how many days interruption risk death disease relapse increases. We conducted retrospective on 299 with using analysis (Kaplan–Meier curve Cox regression) determine probabilities overall survival, local control, disease-free survival. Patients 0 3 therapy had higher probability compared 4 more (90.2% 57.9%, p-value < 0.001), hazard ratio 5.89 (p 0.001). Local control 0–2 people (94% vs. 75.4%, 82.2% 50.5%, respectively, both p-values tumoral nodal downstaging experienced fewer than no downstage. These findings reinforce need radiation oncologists be well-organized when starting cancer, order anticipate prevent potential interruptions achieve best therapeutic results.

Language: Английский

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Biomarkers in Colorectal Cancer: Actual and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11535 - 11535

Published: Oct. 27, 2024

Biomarkers in colorectal cancer (CRC) are of great interest the current literature due to improvements techniques such as liquid biopsy and next-generation sequencing (NGS). However, screening methods vary globally, with multi-target stool DNA (mt-sDNA) predominantly used USA and, more recently, Cologuard Plus; biomarkers Galectins family septins show promise early detection. Gut microbiome assessments, Fusobacterium nucleatum, under intense exploration. Diagnostic tests, circulating analysis via NGS, exhibit effectiveness being increasingly adopted. Circulating tumor cells emerge potential alternatives traditional terms diagnosis prognosis. Predictive well established guidelines; nonetheless, aid machine learning artificial intelligence, these may be improved. This review critically explores actual dynamic landscape CRC future, promising involved screening, diagnosis,

Language: Английский

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Local Control of Advanced Breast Cancer—Debate in Multidisciplinary Tumor Board

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 510 - 510

Published: Jan. 15, 2025

Background/Objectives: In Romania, breast cancer is the second most common cancer, third leading cause of death, and prevalent overall. De novo advanced-stage often presents in clinical practice, treatment decisions are best made a multidisciplinary tumor board (MTD) involving surgeons, radiotherapists, medical oncologists. Significant advances systemic therapies, particularly progression-free survival (PFS) overall (OS), have surpassed traditional palliative mastectomy radiotherapy for local control. Therefore, purpose this study to emphasize importance initial choice patient prognosis. Methods: We expose two cases patients with de severe, advanced-stage, hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative their management outcome using cyclin-dependent kinase (CDK) 4/6 inhibitor radiotherapy. An extensive review literature from past five years was also conducted. Results: The role diminishing, as many opting novel including inhibitors, which may improve quality life. Conclusions: First-line therapy locally advanced has suffered changes due implementation targeted therapy. However, drug resistance—either or acquired—remains critical consideration. MTD discussions informed essential achieving personalized, evidence-based outcome.

Language: Английский

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Phyllodes Tumor of the Breast: A Case Report Regarding the Importance of Fast Interdisciplinary Management

Reports — Medical Cases Images and Videos, Journal Year: 2025, Volume and Issue: 8(1), P. 17 - 17

Published: Feb. 2, 2025

Background and clinical significance: Phyllodes tumors (PTs) are rare stromal neoplasms originating in the connective tissue of breast, distinct from carcinomas that arise ducts or lobules. These exhibit a broad spectrum morphologic features traditionally classified as benign, borderline, malignant. Case presentation: We present case 71-year-old female diagnosed with malignant PT treated at our hospital. The patient noticed gradually enlarging lump her right breast over several months. Mammography was inconclusive, but an ultrasound later revealed lobulated, firm mass, BIRADS 5. Physical examination identified 20 cm core needle biopsy suggested borderline PT. Following lumpectomy, pathology confirmed tumor narrow surgical margins (0.1 cm). Although mastectomy recommended to achieve wider margins, opted for adjuvant radiotherapy. She received 50 Gy 25 fractions whole followed by 16 boost bed 8 fractions. treatment well tolerated completed successfully. Initially, patient’s therapeutic management delayed due combination personal organizational factors. However, process streamlined through use novel digital tool developed facilitate entire journey within hospital system. Conclusions: This highlights diagnostic complexities PTs, critical need effective collaboration between specialties, importance timely planning optimal outcomes.

Language: Английский

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Type I Diabetes—A Rare Adverse Event Described in Patients Receiving Immunotherapy Versus a Side Effect from SARS-CoV-2 Infection

Reports — Medical Cases Images and Videos, Journal Year: 2025, Volume and Issue: 8(1), P. 31 - 31

Published: March 14, 2025

Introduction and Clinical Significance: Lung cancer, a leading cause of global cancer diagnoses, maintains the highest mortality risk despite advances in treatment. Immunotherapy agents, such as anti-programmed death-1/programmed death ligand-1 (PD-1/PD-L1), have revolutionized care for non-small cell lung (NSCLC). However, success is tempered by emergence immune-mediated adverse reactions, including rare onset type I diabetes. The incidence diabetes mellitus increased during SARS-CoV-2 pandemic. While there are several cases new-onset after COVID-19 vaccination, no case 1 was described an immune checkpoint inhibitor (ICI)-treated patient. Case Presentation: A 57-year-old male with stage IV NSCLC (brain liver metastases) who had been treated nivolumab 4 years appeared positive infection at routine check. After two weeks, he admitted to our clinic severe fatigue, hyperglycemia, hyponatremia, hyperkalemia. HbA1c level normal serum peptide C undetectable. Nivolumab treatment ceased, patient became fully dependent on basal–bolus insulin. 3 months, showed complete imagistic remission. Conclusions: presented significant challenges due unclear etiology newly uncommon age which developed. outcome suggests that anti-PD-1 can act synergistically.

Language: Английский

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Enhancing Osteoporosis Management: A Thorough Examination of Surgical Techniques and Their Effects on Patient Outcomes

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Managing osteoporotic fractures in older individuals is a difficult task orthopedic surgery. It requires careful approach that combines advanced diagnostic methods, customized surgical treatments, and comprehensive rehabilitation strategies. This article presents the results of an analysis carried out at University Emergency Hospital, Bucharest. The specifically examines treatment using different osteosynthesis techniques. Although tools like dual-energy X-ray absorptiometry (DXA) Fracture Risk Assessment Tool (FRAX) have improved, considerable number still happen people who do not obvious osteoporosis. emphasizes importance additional measures such as high-resolution peripheral quantitative computed tomography (HR-pQCT) (QCT) to improve accuracy predictions. study demonstrates intricate nature decision-making significance adjusting techniques meet specific needs each patient. An instance failure resulting from inappropriate choice method highlighted crucial thorough preoperative assessment. discussion highlights early mobilization reducing risks associated with prolonged immobilization improving patient recovery. paper strongly supports use evidence-based patient-centered methods management fractures. utilizing most recent advancements technologies. Promising medicine lie future, particularly integration interdisciplinary research personalized medicine. These potential enhance outcomes this population high risk.

Language: Английский

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Practical management of renal cell carcinoma: integrating current approaches with advances in bone metastasis treatment

EFORT Open Reviews, Journal Year: 2024, Volume and Issue: 9(6), P. 488 - 502

Published: June 1, 2024

Renal cell carcinoma (RCC) is a common type of tumor that can develop in the kidney. It responsible for around one-third all cases neoplasms. RCC manifests itself variety distinct subtypes. The most frequent which clear RCC, followed by papillary and chromophobe RCC. has potential metastasis to organs; nevertheless, bone metastases are one potentially fatal complications. These characterized osteolytic lesions result pathological fractures, hypercalcemia, other complications, ultimately lead deterioration quality life an increase morbidity. While nephrectomy remains foundational treatment emerging evidence suggests targeted therapies, including tyrosine kinase inhibitors T checkpoint inhibitors, may offer effective alternatives, obviating need adjuvant certain metastatic Bone continue be difficult complication why more research required enhance patient outcome.

Language: Английский

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Early Presentation of Boerhaave Syndrome in the Emergency Department: A Case Report and Review of the Literature

Diagnostics, Journal Year: 2024, Volume and Issue: 14(15), P. 1592 - 1592

Published: July 24, 2024

We present the case of a 46-year-old patient who arrived at emergency department with chest pain following an episode vomiting. The diagnosis was Boerhaave syndrome and acute mediastinitis. Due to prompt presentation location rupture in lower esophagus, surgical intervention performed, including esophageal suturing, mediastinal drainage, jejunostomy for feeding. Postoperatively, transferred intensive care unit advanced monitoring support. patient's condition improved favorably unit, allowing extubation. Progress continued positively, discharged 12 days postoperatively functional jejunostomy. At regular follow-ups, recovery remained favorable, removed 30 after surgery. This highlights importance rapid early syndrome, demonstrating successful management severe through multidisciplinary effort.

Language: Английский

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Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2013 - 2013

Published: Dec. 6, 2024

Lynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series malignant conditions, among which frequent colorectal but gynecologic cancers (especially endometrial) are also quite common. Despite significant progress made in understanding this condition over time, there still aspects managing that have not demonstrated clear benefits. This article aims summarize recommendations international societies and present latest developments focusing on cancer screening possible prevention strategies. Advances testing procedures discoveries related association between oncological pathology frequency affected pathogenic variant type will probably lead personalized medicine focused individual patient coming years. Although various methods for gynecological patients syndrome been used they shown survival highlights need studying implementing new diagnostic methods, under investigation recent years mentioned article.

Language: Английский

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