Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3766 - 3766

Published: Nov. 8, 2024

The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes disease susceptibility, including cancer.

Language: Английский

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Elderly and bladder cancer: The role of radical cystectomy and orthotopic urinary diversion

Urologia Journal, Journal Year: 2024, Volume and Issue: 91(3), P. 500 - 504

Published: March 29, 2024

The incidence of bladder cancer (BC) depends on advancing age and other risk factors, significantly impacting surgical, functional oncological outcomes. Radical cystectomy (RC) with urinary diversion is the gold standard therapy for muscle invasive cancer; however, it remains a complex surgery requires careful analysis factors in order to potentially decrease post-surgical complication rates. Age limiting factor that can modify surgical outcomes, correlated high rate post-dimssion hospital readmissions. reconstruction intestine represents crucial point radical derivation (UD) at center many debates. A non-continent UD seems be best choice elderly patients (>75 years old), while orthotopic neobladder (ON) poorly practiced. We reviewed literature identify studies reporting complications, patient- selection criteria, quality-of-life data patients, who underwent ON following cystectomy. Reviewing there no clear evidence use as an exclusion criterion. Certainly, patient multiple comorbidities not eligible ON, preferring or rescue therapies. preoperative could greatly improve clinical, giving chance selected receive ON.

Language: Английский

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Previous maximal transurethral resection of bladder tumor lead to unfavorable perioperative outcomes following radical cystectomy

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

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SIRI as a biomarker for bladder neoplasm: Utilizing decision curve analysis to evaluate clinical net benefit

Urologic Oncology Seminars and Original Investigations, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

This analysis aimed to evaluate the clinical relevance of presurgical systemic inflammation response index (SIRI) in individuals undergoing radical cystectomy (RC). In this retrospective study, 228 were categorized into 2 cohorts depending on their SIRI levels using best cut-off determined by Youden Index. The association between and lymph node metastasis (N), advanced pT stage (pT3/pT4), loco-regional extended state analyzed at time surgery. Multivariate Cox regression was performed impact relapse, tumor-specific survival, survival rates. additional medical advantage evaluated through decision curve (DCA). High low group obtained value (1.71×109/l). On multivariate logistic analysis, elevated significantly associated with (P = 0.003) 0.003). multivariable models based clinicopathological factors, an augmented linked poorer relapse-free (RFS) 0.035), improvement concordance just for RFS. DCAs, incorporating yielded results equal or better than those model without all outcomes models. It demonstrated improvements net benefit probability thresholds up 50% adjusted preoperative factors RFS postoperative CSS OS. is innovative prognostic indicator a potential biomarker that can enhance conventional pathological evaluation improve personalization treatment strategies bladder cancer patients following RC.

Language: Английский

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The genetic associations of lipidome on bladder cancer: a Mendelian randomization study

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

Multiple epidemiological studies have demonstrated a correlation between the lipidome and bladder cancer (BC). Nonetheless, current literature lacks consensus on causal link BC. We utilise two-sample Mendelian randomisation approach to meticulously evaluate two variables. A (MR) analysis was performed utilising publically accessible genome-wide association research data. The principal technique utilised for inquiry inverse variance-weighted (IVW) meta-analysis. Furthermore, Bayesian weighted (BWMR) employed corroborate findings. Supplementary validation conducted Cochran's Q test methodologies including MR-Egger. MR analysis, in conjunction with BWMR revealed genetic prediction of risk Sterol ester (SE) 27:1/16:0 (OR: 1.148, 95% CI: 1.020-1.293, p = 0.022), 27:1/20:3 1.132, 1.006-1.274, 0.040), Phosphatidylcholine (PC) 18:0_20:3 1.257, 1.101-1.436, 0.001), Sphingomyelin (SM) d38:1 1.120, 1.016-1.235, 0.023), d40:2 1.156, 1.033-1.295, 0.012), Triacylglycerol (TAG) 46:1 1.178, 1.013-1.369, 0.034), 49:2 1.219, 1.031-1.442, 0.021), 50:5 1.173, 1.038-1.326, 0.011), 52:6 1.161, 1.007-1.339, 0.040) exhibited positive an elevated Genetic projections suggest reciprocal BC, offering theoretical support basis future clinical research.

Language: Английский

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Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 2, 2025

The plasma proteins are an important source of therapeutic targets. This study aims to address the diagnostic and challenges bladder cancer (BC) by using Mendelian randomization (MR) with a large sample size from multiple centers identify which causally related pathogenesis BC. Followed merging nine protein datasets six studies, total 5538 three BC (ieu-b-4874, ukb-b-8193, FinnGen_R11_C3_ BLADDER_EXALL) were used perform proteome‑wide MR estimate contribution BC, separately. To ensure robustness results, Veen intersection operation on results revealed that 14 meaningful candidate pathogenic (ANKRD27, BIN1, FAHD1, IL17RB, MRPL21, PPT1, PSCA, SLC16A3, SLURP1, SPON2, TACSTD2, TMEM87B, YWHAB) obtain datasets. Then, we validated these through various methods, including meta-analysis, reverse MR, Bayesian co-localization analysis summary-data-based (SMR), divided into layers according validation confidence. We then performed single-cell transcriptome (Registration number: GSE222315), showed 13/14 expressed 12 differentially in at least one cell type. Finally, protein-protein interactions (PPI) druggability evaluation explore relationship between interaction markers existing drug Summarily, our research uncovered biomarkers linked risk, offering novel perspectives etiology potential targets for developing screening drugs

Language: Английский

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Systemic immune-inflammation and prognostic immune nutritional index in oral squamous cell carcinoma patients

Biomarkers in Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Sept. 13, 2024

To investigate the systemic immune-inflammation index and prognostic immune nutritional in evaluation of oral squamous cell carcinoma.

Language: Английский

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The role of alternative medicine and complimentary therapies in urologic disease: New horizons

Urologia Journal, Journal Year: 2024, Volume and Issue: 91(4), P. 641 - 646

Published: July 24, 2024

The world of complementary and alternative medicine (CAM) encompasses a wide range practices, treatments, products that fall outside the realm conventional (mainstream) medicine. use CAM has become increasingly popular in Western nations. People are turning to for variety reasons, including managing chronic diseases, relieving symptoms various conditions, improving their overall health well-being. There's growing trend people using showing interest therapies, especially countries. some offering complete alternatives medicine, while others aim complement existing medical approaches. Urologists should stay informed about guide patients effectively treat modern personalized way. review is analyze scenario complimentary with specific focus urological field.

Language: Английский

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Derived Neutrophils to Lymphocyte Ratio Predicts Survival Benefit from TPF Induction Chemotherapy in Local Advanced Oral Squamous Cellular Carcinoma

Cancers, Journal Year: 2024, Volume and Issue: 16(15), P. 2707 - 2707

Published: July 30, 2024

This study aimed to evaluate the derived neutrophil lymphocyte ratio (dNLR) in predicting prognosis of patients with locally advanced oral squamous cell carcinoma (LAOSCC) and assess survival benefits from docetaxel, cisplatin, 5-fluorouracil (5-FU) (TPF) induction chemotherapy (IC).

Language: Английский

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Prognostic impact of lymph node invasion levels in patients with bladder cancer undergoing radical cystectomy and pelvic lymphadenectomy

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(5)

Published: Aug. 29, 2024

Extranodal extension in metastatic lymph nodes (LNs) is a poor prognostic factor bladder cancer (BC). Furthermore, invasion levels sentinel LNs are associated with prognosis melanoma. The present study aimed to evaluate the LN level, defined as extent of anatomical and immunological substructures, compare it pathological node (pN) stage tumor‑node‑metastasis staging system BC. A total 98 patients BC who underwent radical cystectomy pelvic lymphadenectomy were retrospectively assessed. level was classified follows: Level 0, no cell within resected LNs; 1, cells confined intracapsular vessels subcapsular or transverse sinuses; 2, infiltrating cortex, paracortex medulla; 3, beyond capsule. proportion Levels 2 3 70.4% (69/98), 8.2% (8/98), 14.3% (14/98) 7.1% (7/98), respectively. Kaplan‑Meier survival curves recurrence‑free (RFS), cancer‑specific (CSS) overall (OS) better stratified outcome patient when using 1‑3 compared pN1‑3. In addition, predicted RFS, CSS OS, comparison pN (c‑index 0.672 vs. 0.646, 0.688 0.665, 0.702 0.661, respectively). Finally, multivariate analysis revealed that predictive accuracy model integrating tumor (pT) OS greater than conventional included pT 0.723 0.703, 0.710 0.694, 0.725 0.692, conclusion, accurately after lymphadenectomy.

Language: Английский

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