Anti-Aging Effects of Flavonoids from Plant Extracts

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441

Published: Aug. 2, 2024

Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.

Language: Английский

Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Feb. 18, 2025

Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found CCK8 TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis restrain migration. Explored whole-transcriptome sequencing LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated 79 proteins 84 in resveratrol-treated fibroblasts. shown KEGG, GO, PPI the following bioinformatics analysis resveratrol may affect migration of fibroblast through TGFB2/3 COL1A1/2.

Language: Английский