SIRT5 participates in the suppressive tumor immune microenvironment of EGFR-mutant LUAD by regulating the succinylation of ACAT1 DOI Creative Commons

Wang Shouhan,

Qingchang Li, Xiaodan Sun

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39743 - e39743

Published: Oct. 23, 2024

Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) exhibits a poor response to immune checkpoint inhibitors (ICIs) by shaping suppressive tumor microenvironment (TIME), which characters as lacking cell infiltration; however, the underlying mechanism remains be elucidated. Here, we demonstrated that Sirtuin 5 (SIRT5), member of deacetylase SIRT family, functions desuccinylase acetyl-CoA acetyltransferase 1 (ACAT1) and enhances enzymatic activity ACAT1 activate NRF2 pathway, inhibiting secretion chemokines CCL5 CXCL10, are important for recruiting CD8

Language: Английский

SIRT5 participates in the suppressive tumor immune microenvironment of EGFR-mutant LUAD by regulating the succinylation of ACAT1 DOI Creative Commons

Wang Shouhan,

Qingchang Li, Xiaodan Sun

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39743 - e39743

Published: Oct. 23, 2024

Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) exhibits a poor response to immune checkpoint inhibitors (ICIs) by shaping suppressive tumor microenvironment (TIME), which characters as lacking cell infiltration; however, the underlying mechanism remains be elucidated. Here, we demonstrated that Sirtuin 5 (SIRT5), member of deacetylase SIRT family, functions desuccinylase acetyl-CoA acetyltransferase 1 (ACAT1) and enhances enzymatic activity ACAT1 activate NRF2 pathway, inhibiting secretion chemokines CCL5 CXCL10, are important for recruiting CD8

Language: Английский

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