Isolation of circulating tumor cells: recent progress and future perspectives DOI Creative Commons
Z. H. Guo, Weiliang Xia

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 24, 2024

Abstract Circulating tumor cells (CTCs) are cancer that shed from the primary and enter into body fluids of patient, where they travel to distant sites ultimately form metastasis. Understanding biology CTCs, in particular at critical stages their itinerary, holds promises for better cure. Since beginning this century, liquid biopsy has steadily grown be a keen area research due its non-invasive features. As one most promising biomarkers, CTCs have shown great potential diagnosis, prognosis, treatment response monitoring, exploration biological mechanisms. Although various types isolation detection technologies emerge constantly, rarity heterogeneity still pose huge challenges these methods make them inefficient. In addition, clinical practice different lacks reasonable uniform standards. review, we provide detailed overview enrichment strategies as well advantages limitations. By summarizing current status suggesting future areas research, hope continue concerted effort pushing forward application which may represent paradigm shift theranostics future. Graphical

Language: Английский

Liquid biopsy in cancer current: status, challenges and future prospects DOI Creative Commons
Liwei Ma, Huiling Guo, Yunxiang Zhao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 1, 2024

Cancer has a high mortality rate across the globe, and tissue biopsy remains gold standard for tumor diagnosis due to its level of laboratory standardization, good consistency results, relatively stable samples, accuracy results. However, there are still many limitations drawbacks in application tumor. The emergence liquid provides new ideas early prognosis Compared with biopsy, advantages treatment various types cancer, including non-invasive, quickly so on. Currently, detection received widely attention. It is now undergoing rapid progress, it holds significant potential future applications. Around now, biopsies encompass several components such as circulating cells, DNA, exosomes, microRNA, RNA, platelets, endothelial cells. In addition, advances identification indicators have significantly enhanced possibility utilizing clinical settings. this review, we will discuss application, challenges some common tumors from perspective diverse systems tumors, look forward development prospects field cancer treatment.

Language: Английский

Citations

37
Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer DOI Creative Commons
Shan Liu,

Xingda Zhang,

Wenzheng Wang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 21, 2024

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.

Language: Английский

Citations

16
Unravelling the biological and clinical challenges of circulating tumour cells in epithelial ovarian carcinoma DOI Creative Commons
F. Park Lewis, James Beirne,

Brian E. Henderson

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217279 - 217279

Published: Sept. 1, 2024

Language: Английский

Citations

4
Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer DOI
Shaimaa A. Gouhar, Zakaria Y. Abd Elmageed, Sherien M. El‐Daly

et al.

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhancing detection and monitoring of circulating tumor cells: Integrative approaches in liquid biopsy advances DOI Creative Commons

Thanmayi Velpula,

Buddolla Viswanath

The Journal of Liquid Biopsy, Journal Year: 2025, Volume and Issue: unknown, P. 100297 - 100297

Published: April 1, 2025

Language: Английский

Citations

0
Shaping future diagnostics: advances and innovations in cancer biomarker science DOI

M.A. Abdelsamed

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 333 - 357

Published: Jan. 1, 2025

Language: Английский

Citations

0
Extracellular vesicles as novel uro-oncology biomarkers: insights toward clinical applications DOI
Fumihiko Urabe, Tomohiro Tamura, Shinichi Sakamoto

et al.

Current Opinion in Urology, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Purpose of review We discussed the challenges associated with clinical application extracellular vesicles and summarized their potential impact on oncological practice in urology. Recent findings Despite extensive research vesicles, applications remain limited; this is likely to be because small study cohorts, a lack large-scale analyses, variable extraction storage methods analysis outcomes. However, promising results have emerged from trials targeting urinary prostate cancer using ExoDx Prostate Test. The Test has demonstrated its efficacy diagnosing previous studies only FDA-approved kit for purpose. Moreover, recent investigated use determine optimal timing biopsies patients undergoing active surveillance. Summary management urological cancers. Particularly, diagnosis yielded positive several trials. Additionally, while there are other suggesting efficacy, most these based retrospective analyses. These warrant further optimize vesicle-based diagnostic monitoring strategies. Although required, would attractive early detection

Language: Английский

Citations

1
Liquid biopsy in oral cancer detection: A promising frontier in non-invasive diagnostics DOI Creative Commons
Santosh Patil,

Shikhar Daniel

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100467 - 100467

Published: April 29, 2024

Language: Английский

Citations

0
Detection, significance and potential utility of circulating tumor cells in clinical practice in breast cancer (Review) DOI Open Access

Dominika Rusnáková,

Ramadan Aziri,

Peter Dubovan

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 17, 2024

Although advances in diagnostic techniques, new therapeutic strategies and personalization of breast cancer (BC) care have improved the survival for a number patients, BC remains major cause morbidity mortality women. The study circulating tumor cells (CTCs) has significant potential translational oncology since these represent promising biomarkers throughout entire course patients. CTCs also notable prognostic value early as well metastatic BC. Based on current knowledge, it seems that dynamics change during therapy reflect response, could serve tool risk stratification real-time monitoring treatment patients with question how to use this information everyday clinical practice can guide or affect outcome unanswered. present review aims discuss completed ongoing trials been designed demonstrate significance CTCs, offer insights into efficacy assess CTC utility, facilitating their implementation routine management

Language: Английский

Citations

0
Isolation of circulating tumor cells: recent progress and future perspectives DOI Creative Commons
Z. H. Guo, Weiliang Xia

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 24, 2024

Abstract Circulating tumor cells (CTCs) are cancer that shed from the primary and enter into body fluids of patient, where they travel to distant sites ultimately form metastasis. Understanding biology CTCs, in particular at critical stages their itinerary, holds promises for better cure. Since beginning this century, liquid biopsy has steadily grown be a keen area research due its non-invasive features. As one most promising biomarkers, CTCs have shown great potential diagnosis, prognosis, treatment response monitoring, exploration biological mechanisms. Although various types isolation detection technologies emerge constantly, rarity heterogeneity still pose huge challenges these methods make them inefficient. In addition, clinical practice different lacks reasonable uniform standards. review, we provide detailed overview enrichment strategies as well advantages limitations. By summarizing current status suggesting future areas research, hope continue concerted effort pushing forward application which may represent paradigm shift theranostics future. Graphical

Language: Английский

Citations

0