Multi-omic profiling in breast cancer: utility for advancing diagnostics and clinical care DOI
Emna El Gazzah, Scott Parker, Mariaelena Pierobon

et al.

Expert Review of Molecular Diagnostics, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Breast cancer remains a major global health challenge. While advances in precision oncology have contributed to improvements patient outcomes and provided deeper understanding of the biological mechanisms that drive disease, historically, research patients' allocation treatment heavily relied on single-omic approaches, analyzing individual molecular dimensions such as genomics, transcriptomics, or proteomics. these deep insights into breast biology, they often fail offer complete disease's complex landscape. In this review, authors explore recent advancements multi-omic realm using clinical data show how integration can more holistic alterations their functional consequences underlying cancer. The overall developments AI are expected complement diagnostics through potentially refining prognostic models, selection. Overcoming challenges cost, complexity, lack standardization is crucial for unlocking full potential multi-omics care enable advancement personalized treatments improve outcomes.

Language: Английский

Advancing Optical Nanosensors with Artificial Intelligence: A Powerful Tool to Identify Disease-Specific Biomarkers in Multi-omics Profiling DOI
Bakr Ahmed Taha,

Zahraa Mustafa Abdulrahm,

Ali J. Addie

et al.

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127693 - 127693

Published: Feb. 4, 2025

Language: Английский

Citations

4
Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization DOI Open Access
Yusheng Zhang, Zhiguo Lü, Jing Guo

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.

Language: Английский

Citations

0
Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review DOI

VEENA V. TOM,

A. De la Fuente Hernández José, Sumit Mallick

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Multi-omic profiling in breast cancer: utility for advancing diagnostics and clinical care DOI
Emna El Gazzah, Scott Parker, Mariaelena Pierobon

et al.

Expert Review of Molecular Diagnostics, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Breast cancer remains a major global health challenge. While advances in precision oncology have contributed to improvements patient outcomes and provided deeper understanding of the biological mechanisms that drive disease, historically, research patients' allocation treatment heavily relied on single-omic approaches, analyzing individual molecular dimensions such as genomics, transcriptomics, or proteomics. these deep insights into breast biology, they often fail offer complete disease's complex landscape. In this review, authors explore recent advancements multi-omic realm using clinical data show how integration can more holistic alterations their functional consequences underlying cancer. The overall developments AI are expected complement diagnostics through potentially refining prognostic models, selection. Overcoming challenges cost, complexity, lack standardization is crucial for unlocking full potential multi-omics care enable advancement personalized treatments improve outcomes.

Language: Английский

Citations

0