Clinical and Preventive Medicine, Journal Year: 2025, Volume and Issue: 2, P. 14 - 22
Published: April 17, 2025
Introduction. Quality of life (QoL) studies in patients with oropharyngeal cancer can assist formulating targeted treatment plans, optimising patient care, and improving follow-up strategies. Aim. To conduct a dynamic prospective study the quality stage III-IV cancer, focusing on assessing long-term functional outcomes. Materials methods. A comprehensive involved clinical morphological examinations, pathohistological immunohistochemical analyses selected biopsy samples, QoL assessments 120 (T3-4N0-3M0-1). These underwent inpatient at ENT-2 (oncology) department Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov, Council, between 2018 2023. was assessed three time points: during treatment, 3- 6-months post-treatment, by bioethical principles using EORTC QLQ-HN43 questionnaire module. Statistical analysis performed Microsoft Excel (https://www.microsoft.com/microsoft-365/free-office-online-for-the-web) R Commander (version 4.2.1 – https://www.R-project.org). Results. Patients who (surgery, radiation therapy, and/or chemotherapy) demonstrated better short-term outcomes 3 months post-treatment compared to those received monotherapy. However, these also exhibited increased levels anxiety. By 6 all experienced significant improvements QoL, including reduced pain improved swallowing function. Comprehensive surgery, chemotherapy, more effective achieving than Despite elevated anxiety levels, strategy showed an overall positive impact both psychosocial aspects patients' QoL. Conclusions. The strategy, grounded examinations analyses, proved be effective. This evidenced particularly terms reduction function, observed post-treatment.
Language: Английский