Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women DOI Creative Commons
Fei Jing,

L Zhai,

Jing Wang

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 26, 2024

Referring all women who tested positive for human papillomavirus (HPV) 16/18 to colposcopy may lead potential over-referral issues. Triage tests based on cytology results face challenges in achieving accurate diagnoses. Our study aims assess the clinical effectiveness of PAX1/JAM3 methylation (CISCER) test as a triage method HPV 16/18-positive women. From November 2021 December 2022, total 334 and were referred at The Second Affiliated Hospital Zhejiang University School Medicine studied. utility CISCER test, cytology, combination with was compared. We observed significant increase levels PAX1 gene JAM3 cervical intraepithelial neoplasia (CIN) grade 2 or severe (CIN2+). demonstrated superior performance over even when used showing high sensitivity 89.0% (95% confidence interval [CI] 82.9–95.1%) specificity 95.3% CI 92.6–98.0%). It achieved an area under curve 0.921 0.877–0.966) odds ratio 164.02 68.64–391.95). immediate CIN2+ risk would be 80.8–94.1%), estimated average 1.12 referrals needed detect one case. Moreover, triaging successfully identified cancer patients did not miss any CIN3+ cases among aged ≥ 30. detection exhibited excellent accuracy identifying precancerous lesions could considered tool reduce excessive overtreatment.

Language: Английский

Clonal hematopoiesis of indeterminate potential: recent developments and perspectives DOI
Meiqi Guo,

Yuan Li,

Baobing Zhao

et al.

Current Opinion in Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Purpose of review This encompasses the recently published information on clonal hematopoiesis indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in research CHIP risk factors related diseases, with purpose offering new insights to treat both hematologic nonhematologic disorders. Recent findings The majority studies have shown that is a common biological condition associated aging incidence increases age. pathophysiology blood diseases projected be significantly influenced by CHIP. Nevertheless, increasing expanded application cover such as cardiovascular, renal, liver, pulmonary diseases. Furthermore, fast advancement genetic testing technology preventive medicine, involvement variety disorders shows promise an essential target for preventing disease onset progression. Summary linked illnesses has significant influence individual's health outlook. Thus, identifying managing critical improving clinical results individuals concerned.

Language: Английский

Citations

0
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women DOI Creative Commons
Fei Jing,

L Zhai,

Jing Wang

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 26, 2024

Referring all women who tested positive for human papillomavirus (HPV) 16/18 to colposcopy may lead potential over-referral issues. Triage tests based on cytology results face challenges in achieving accurate diagnoses. Our study aims assess the clinical effectiveness of PAX1/JAM3 methylation (CISCER) test as a triage method HPV 16/18-positive women. From November 2021 December 2022, total 334 and were referred at The Second Affiliated Hospital Zhejiang University School Medicine studied. utility CISCER test, cytology, combination with was compared. We observed significant increase levels PAX1 gene JAM3 cervical intraepithelial neoplasia (CIN) grade 2 or severe (CIN2+). demonstrated superior performance over even when used showing high sensitivity 89.0% (95% confidence interval [CI] 82.9–95.1%) specificity 95.3% CI 92.6–98.0%). It achieved an area under curve 0.921 0.877–0.966) odds ratio 164.02 68.64–391.95). immediate CIN2+ risk would be 80.8–94.1%), estimated average 1.12 referrals needed detect one case. Moreover, triaging successfully identified cancer patients did not miss any CIN3+ cases among aged ≥ 30. detection exhibited excellent accuracy identifying precancerous lesions could considered tool reduce excessive overtreatment.

Language: Английский

Citations

1