Gels,
Journal Year:
2023,
Volume and Issue:
9(9), P. 700 - 700
Published: Aug. 29, 2023
Sustained
release
is
highly
desired
for
"efficacious,
safe
and
convenient"
drug
delivery,
particularly
those
anticancer
molecules
with
toxicity.
In
this
study,
a
modified
coaxial
electrospraying
process
was
developed
to
coat
hydrophobic
lipid,
i.e.,
stearic
acid
(SA),
on
composites
composed
of
the
tamoxifen
citrate
(TC)
insoluble
polymeric
matrix
ethylcellulose
(EC).
Compared
electrosprayed
TC-EC
composite
microparticles
M1,
SA-coated
hybrid
M2
were
able
provide
an
improved
TC
sustained-release
profile.
The
30%
90%
loaded
time
periods
extended
3.21
h
19.43
M2,
respectively,
which
significantly
longer
than
provided
by
M1
(0.88
9.98
h,
respectively).
morphology,
inner
structure,
physical
state,
compatibility
components
particles
disclosed
through
SEM,
TEM,
XRD,
FTIR.
Based
analyses,
mechanism
multiple
factors
co-acting
suggested,
include
reasonable
selections
organizations
lipid
excipient,
blank
SA
shell
loading,
regularly
round
shape,
also
high
density.
reported
protocols
pioneered
brand-new
manner
developing
sustained
delivery
hybrids
combination
cellulose
gels
using
electrospraying.
Macromolecular Materials and Engineering,
Journal Year:
2023,
Volume and Issue:
309(4)
Published: Nov. 23, 2023
Abstract
In
this
study,
three
kinds
of
electrohydrodynamic
atomization
(EHDA)
processes
(electrospraying,
electrospinning,
and
coaxial
electrospinning)
are
implemented
to
create
hydroxypropyl
methylcellulose
(HPMC)
based
ultra‐thin
products
for
providing
the
fast
dissolution
a
poorly
water‐soluble
drug
ketoprofen
(KET).
An
EHDA
apparatus,
characterized
by
novel
spinneret,
is
homemade
conducting
processes.
The
types
electrospun
nanofibers
E1,
electrosprayed
microparticles
E2,
core‐shell
E3.
SEM
TEM
results
indicate
that
they
have
anticipated
morphologies
inner
structures.
X‐ray
diffraction
Fourier
Transform
Infrared
verify
KET
mainly
amorphous
in
all
composites
due
its
fine
compatibility
with
HPMC.
vitro
tests
demonstrate
rapid
release
performances
has
an
order
E3>E1>E2≫KET
powders.
mechanisms
suggested
advantages
compared.
super
performance
E3
furnishing
attributed
synergistic
action
small
size
(of
shell
thickness),
high
porosity,
state
drug,
solubility
nanostructures
can
support
development
nano
delivery
systems
(DDSs)
through
tailoring
spatial
distribution
molecules
within
products.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2561 - 2561
Published: Oct. 31, 2023
Polymers
are
the
backbone
of
drug
delivery.
Electrospinning
has
greatly
enriched
strategies
that
have
been
explored
for
developing
novel
delivery
systems
using
polymers
during
past
two
decades.
In
this
study,
four
different
kinds
polymers,
i.e.,
water-soluble
polymer
poly
(vinyl
alcohol)
(PVA),
insoluble
poly(ε-caprolactone)
(PCL),
Eudragit
RL100
(ERL100)
and
pH-sensitive
S100
(ES100)
were
successfully
converted
into
types
tri-layer
tri-polymer
core-shell
fibers
through
bi-fluid
coaxial
electrospinning.
During
process,
model
metronidazole
(MTD)
was
loaded
shell
working
fluid,
which
an
emulsion.
The
micro-formation
mechanism
from
emulsion
electrospinning
proposed.
Scanning
electron
microscope
transmission
evaluations
verified
linear
morphology
resultant
their
obvious
multiple-chamber
structures.
X-ray
diffraction
Fourier
transform
infrared
spectroscopy
measurements
demonstrated
MTD
presented
in
amorphous
state
compatible
with
three
polymeric
matrices.
vitro
dissolution
tests
could
act
a
synergistic
manner
prolonged
sustained-release
profile
gut.
controlled-release
mechanisms
suggested
detail.
protocols
reported
here
pioneer
new
route
creating
structure
both
aqueous
organic
solvents,
strategy
advanced
sophisticated
profiles.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 15, 2023
Bacterial
prostatitis
is
a
challenging
condition
to
treat
with
traditional
dosage
forms.
Physicians
often
prescribe
variety
of
forms
different
administration
methods,
which
fail
provide
an
efficient
and
convenient
mode
drug
delivery.
The
aim
this
work
was
develop
new
type
hybrid
material
incorporating
both
electrosprayed
core-shell
microparticles
electrospun
nanofibers.
A
Chinese
medicine
(Ningmitai,
NMT)
Western
(ciprofloxacin,
CIP)
were
co-encapsulated
within
designed
be
released
in
separately
controlled
manner.
Utilizing
polyvinylpyrrolidone
(PVP)
as
hydrophilic
filament-forming
polymer
pH-sensitive
Eudragit
®
S100
(ES100)
the
particulate
polymeric
matrix,
combined
electrohydrodynamic
atomization
(EHDA)
method
comprising
coaxial
electrospraying
blending
electrospinning,
used
create
hybrids
single-step
straightforward
series
characterization
methods
conducted
analyze
working
process
its
final
products.
Scanning
electron
microscopy
transmission
revealed
that
EHDA
comprised
CIP-PVP
nanofibers
NMT-ES100
microparticles.
Multiple
confirmed
rapid
release
CIP
sustained
NMT.
antibacterial
experiments
indicated
exhibited
more
potent
effect
against
Escherichia
coli
dh5α
Bacillus
subtilis
Wb800
than
either
separate
or
amalgamation
fibrous
nanomedicine
micromedicine
can
expand
horizon
types
medicines.
integration
electrospinning
provides
approach
fabrication.
By
combining
soluble
polymers
hybrids,
we
ensure
sequential
NMT
for
potential
synergistic
therapy
bacterial
prostatitis.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
238, P. 112657 - 112657
Published: Jan. 10, 2024
A
tri-fluid
electrospinning
process
was
successfully
developed
to
prepare
tri-chamber
complex
nanofibers.
The
core–shell
and
Janus
structure
were
combined
form
a
delicate
complicated
architecture
for
solving
the
problem
of
co-administration
quercetin
tamoxifen
citrate,
improving
oral
bioavailability,
enhancing
their
synergistic
anti-breast
cancer
actions.
Scanning
electron
microscope,
transmission
microscope
confocal
fluorescent
microscopy
images
showed
designed
Fourier
transform
infrared
X-ray
diffraction
analyses
verified
that
model
drugs
polymeric
excipients
had
good
compatibility
presented
in
an
amorphous
state.
vitro
release
study
certified
nanofibers
facilitated
rapid
compared
with
crude
drug
(90%
versus
38%)
delayed
sustained
citrate
at
same
time
interval
(decreased
by
1.88
times).
vivo
pharmacokinetic
pharmacodynamic
analysis
could
result
increased
bioavailability
enhanced
anticancer
action
citrate.
findings
proved
new
medicated
delivery
system
advanced
dual-,
time-,
target-specific
profiles
using
electrospun
nanostructure.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 5, 2024
Diabetic
wounds
are
a
significant
subset
of
chronic
characterized
by
elevated
levels
inflammatory
cytokines,
matrix
metalloproteinases
(MMPs),
and
reactive
oxygen
species
(ROS).
They
also
associated
with
impaired
angiogenesis,
persistent
infection,
high
likelihood
hospitalization,
leading
to
substantial
economic
burden
for
patients.
In
severe
cases,
amputation
or
even
mortality
may
occur.
foot
ulcers
(DFUs)
common
complication
diabetes,
up
25%
diabetic
patients
being
at
risk
developing
over
their
lifetime,
more
than
70%
ultimately
requiring
amputation.
Electrospun
scaffolds
exhibit
structural
similarity
the
extracellular
(ECM),
promoting
adhesion,
growth,
migration
fibroblasts,
thereby
facilitating
formation
new
skin
tissue
wound
site.
The
composition
size
electrospun
can
be
easily
adjusted,
enabling
controlled
drug
release
through
fiber
structure
modifications.
porous
nature
these
facilitates
gas
exchange
absorption
exudate.
Furthermore,
surface
readily
modified
impart
specific
functionalities,
making
electrospinning
nanofiber
highly
promising
treatment
wounds.
This
article
provides
concise
overview
healing
process
in
normal
pathological
mechanisms
underlying
wounds,
including
complications
such
as
ulcers.
It
explores
advantages
treatment.
Additionally,
it
summarizes
findings
from
various
studies
on
use
different
types
reviews
methods
loading
onto
scaffolds.
These
advancements
broaden
horizon
effectively
treating
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(5), P. 3359 - 3378
Published: Jan. 1, 2024
Electrostatic
spinning
as
a
technique
for
producing
nanoscale
fibers
has
recently
attracted
increasing
attention
due
to
its
simplicity,
versatility,
and
loadability.
