International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132743 - 132743
Published: May 30, 2024
Language: Английский
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(4), P. 1053 - 1073
Published: April 12, 2024
Language: Английский
Citations
72
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)
Published: May 1, 2024
Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies
Language: Английский
Citations
64
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152359 - 152359
Published: May 18, 2024
Language: Английский
Citations
45
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124180 - 124180
Published: May 4, 2024
Language: Английский
Citations
38
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132113 - 132113
Published: May 6, 2024
Language: Английский
Citations
37
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 5, 2024
Diabetic wounds are a significant subset of chronic characterized by elevated levels inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They also associated with impaired angiogenesis, persistent infection, high likelihood hospitalization, leading to substantial economic burden for patients. In severe cases, amputation or even mortality may occur. foot ulcers (DFUs) common complication diabetes, up 25% diabetic patients being at risk developing over their lifetime, more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit structural similarity the extracellular (ECM), promoting adhesion, growth, migration fibroblasts, thereby facilitating formation new skin tissue wound site. The composition size electrospun can be easily adjusted, enabling controlled drug release through fiber structure modifications. porous nature these facilitates gas exchange absorption exudate. Furthermore, surface readily modified impart specific functionalities, making electrospinning nanofiber highly promising treatment wounds. This article provides concise overview healing process in normal pathological mechanisms underlying wounds, including complications such as ulcers. It explores advantages treatment. Additionally, it summarizes findings from various studies on use different types reviews methods loading onto scaffolds. These advancements broaden horizon effectively treating
Language: Английский
Citations
36
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3171 - 3190
Published: Jan. 1, 2024
This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.
Language: Английский
Citations
36
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 646 - 646
Published: April 8, 2024
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded active ingredients for providing functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed polycaprolactone fenoprofen core working fluid, different types unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid hydroxyapatite, dilute polymeric comprising acid, polyvinylpyrrolidone) explored to implement processes creating multifunctional nanofibers. Their morphologies inner structures assessed through scanning transmission electron microscopes, which all showed a linear format without discerned beads or spindles diameter smaller than 1.0 μm, some them had incomplete core–shell nanostructures, represented by symbol @. Additionally, strange details about sheaths’ topographies observed, included cracks, adhesions, embedded nanoparticles. XRD FTIR verified that drugs presented amorphous state, resulted from fine compatibility among involved components. All samples demonstrated have hydrophilic property exhibited lower water contact angle 40° 300 ms. In vitro dissolution tests indicated was released sustained manner over 6 h typical Fickian diffusion mechanism. Hemostatic intentional distribution on shell sections able endow rapid hemostatic effect within 60 s.
Language: Английский
Citations
33
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(2)
Published: March 1, 2024
Core-shell structure is a concentric circle found in nature. The rapid development of electrospinning technology provides more approaches for the production core-shell nanofibers. nanoscale effects and expansive specific surface area nanofibers can facilitate dissolution drugs. By employing ingenious structural designs judicious polymer selection, specialized nanofiber drug delivery systems be prepared to achieve controlled release. synergistic combination materials exhibits strong strategy enhancing utilization efficiency customizing release profile Consequently, multi-chamber hold great promise highly efficient disease treatment. However, little attention concentration focused on effect In this review, we introduced different fabrication techniques nanostructures, including advanced technologies functionalization. Subsequently, reviewed behaviors their potential needs comprehensive elucidation based electrospun nanostructures could inspire exploration novel systems. Furthermore, once these fibers with customizable profiles move toward industrial mass production, they will potentially promote pharmacy treatment various diseases. This article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies.
Language: Английский
Citations
33
Polymers, Journal Year: 2024, Volume and Issue: 16(4), P. 504 - 504
Published: Feb. 12, 2024
In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains pressing challenge. Utilizing electrospinning to support drugs offers sustained and controlled release methods in contrast oral implantable delivery modes, which enable localized of distinct tumor types. Moreover, core–sheath structure bears advantages dual-drug loading: core sheath layers can carry different drugs, facilitating collaborative counter resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport but also integrate metal particles targeted compounds, enabling combinations magnetic heat therapies comprehensive cancer treatment. review delves into preparation techniques tailored various cancers, foreseeing their promising roles
Language: Английский
Citations
32