Medicine,
Journal Year:
2024,
Volume and Issue:
103(13), P. e37654 - e37654
Published: March 29, 2024
Breast
cancer
remains
a
pressing
global
health
concern,
with
myriad
of
intricate
factors
contributing
to
its
development,
progression,
and
heterogeneity.
Among
these
multifaceted
elements,
the
role
immune
cells
within
tumor
microenvironment
is
gaining
increasing
attention.
In
this
context,
neutrophils,
traditionally
regarded
as
first
responders
infections,
are
emerging
noteworthy
participants
in
complex
landscape
breast
cancer.
This
paper
seeks
unravel
neutrophils
Neutrophils,
classically
known
for
their
phagocytic
pro-inflammatory
functions,
now
recognized
involvement
promoting
or
restraining
growth.
While
presence
may
exert
antitumor
effects
through
surveillance
cytotoxic
activities,
innate
can
also
facilitate
progression
by
fostering
an
immunosuppressive
milieu,
angiogenesis,
aiding
metastatic
dissemination.
The
intricacies
neutrophil-tumor
cell
interactions,
signaling
pathways,
mechanisms
governing
recruitment
site
explored
detail.
Challenges
gaps
current
knowledge
acknowledged,
future
directions
research
outlined.
review
underscores
dynamic
context-dependent
emphasizes
significance
unraveling
contributions.
As
we
delve
into
complexities
cancer,
deeper
understanding
warriors
within,
presents
exciting
prospects
development
novel
therapeutic
strategies
more
comprehensive
approach
management.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 19, 2024
Cancer
is
one
of
the
most
concerning
public
health
issues
and
breast
cancer
common
cancers
in
world.
The
immune
cells
within
tumor
microenvironment
regulate
development.
In
this
study,
single
cell
data
sets
were
used
to
identify
marker
gene
for
exhausted
CD8
+
T
(CD8Tex)
cancer.
Machine
learning
methods
cluster
subtypes
establish
prognostic
models
with
bulk
using
evaluate
impacts
CD8Tex.
We
analyzed
overexpressing
survival-associated
genes
identified
CD8Tex
hub
protein-protein-interaction
network.
relevance
T-cells
was
evaluated.
clinical
associations
sequencing
spatial
data.
pan-cancer
expression,
survival,
association
analyzed.
biomarker
CD8Tex-based
subtyping
systems
performed
well
separation
patients
different
survival.
CRTAM,
CLEC2D,
KLRB1
as
demonstrated
have
potential
therapy
impact.
This
study
provides
a
unique
view
critical
therapy.
Expert Opinion on Investigational Drugs,
Journal Year:
2022,
Volume and Issue:
31(6), P. 593 - 605
Published: March 21, 2022
Most
breast
cancer-related
deaths
arise
from
triple-negative
cancer
(TNBC).
Molecular
heterogeneity,
aggressiveness
and
the
lack
of
effective
therapies
are
major
hurdles
to
therapeutic
progress.
Chimeric
antigen
receptor
(CAR)-T
cells
have
emerged
as
a
promising
immunotherapeutic
strategy
in
TNBC.
This
approach
combines
specificity
an
antibody
with
effector
function
T
cells.This
review
examines
opportunities
provided
by
CAR-T
cell
solid
tumors.
Emerging
targets,
ongoing
clinical
trials,
prospective
implications
TNBC
considered
later.
An
emphasis
is
placed
on
key
challenges
possible
solutions
for
this
approach.A
challenge
therapy
selection
optimal
targets
minimize
on-target/off-tumor
toxicity.
Tumor
escape
via
loss
intrinsic
heterogeneity
further
hurdle.
TROP2,
GD2,
ROR1,
MUC1
EpCAM
targets.
Persistence
trafficking
tumor
may
be
enhanced
implementation
CARs
chemokine
and/or
constitutively
activated
interleukin
receptors.
Fourth-generation
(TRUCKs)
redirect
T-cells
universal
cytokine-mediated
killing.
Combinatorial
approaches
application
other
immune
could
revert
suppressive
environment
that
characterizes
neoplasms.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15332 - 15332
Published: Oct. 18, 2023
Breast
cancer
(BC),
one
of
the
most
widespread
and
devastating
diseases
affecting
women
worldwide,
presents
a
significant
public
health
challenge.
This
review
explores
emerging
frontiers
research
focused
on
deciphering
intricate
interplay
between
BC
cells
immune
microenvironment.
Understanding
role
system
in
is
critical
as
it
holds
promise
for
novel
therapeutic
approaches
precision
medicine
strategies.
delves
into
current
literature
regarding
microenvironment's
contribution
to
initiation,
progression,
metastasis.
It
examines
complex
mechanisms
by
which
interact
with
various
cell
populations,
including
tumor-infiltrating
lymphocytes
(TILs)
tumor-associated
macrophages
(TAMs).
Furthermore,
this
highlights
impact
immune-related
factors,
such
cytokines
checkpoint
molecules.
Additionally,
comprehensive
analysis
sheds
light
potential
biomarkers
associated
response
BC,
enabling
early
diagnosis
prognostic
assessment.
The
implications
targeting
microenvironment
are
also
explored,
encompassing
immunotherapeutic
strategies
combination
therapies
enhance
treatment
efficacy.
significance
lies
its
pave
way
interventions,
providing
clinicians
researchers
essential
knowledge
design
targeted
personalized
regimens
patients.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(6)
Published: May 23, 2024
Abstract
Cancer
is
one
of
the
leading
causes
death
worldwide,
and
more
effective
ways
attacking
cancer
are
being
sought.
immunotherapy
a
new
therapeutic
method
after
surgery,
radiotherapy,
chemotherapy,
targeted
therapy.
aims
to
kill
tumor
cells
by
stimulating
or
rebuilding
body's
immune
system,
with
specific
efficiency
high
safety.
However,
only
few
patients
respond
due
complex
variable
characters
escape,
behavior
regulatory
mechanisms
need
be
deeply
explored
from
dimensions.
Epigenetic
modifications,
metabolic
modulation,
cell‐to‐cell
communication
key
factors
in
cell
adaptation
response
microenvironment.
They
collectively
determine
state
function
through
modulating
gene
expression,
changing
energy
nutrient
demands.
In
addition,
engage
networks
other
components,
which
mediated
exosomes,
cytokines,
chemokines,
pivotal
shaping
progression
response.
Understanding
interactions
combined
effects
such
multidimensions
modulation
important
for
revealing
failure
developing
targets
strategies.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1626 - 1626
Published: April 23, 2024
TIICs
are
critical
components
of
the
TME
and
used
to
estimate
prognostic
treatment
responses
in
many
malignancies.
tumor
microenvironment
assessed
quantified
by
categorizing
immune
cells
into
three
subtypes:
CD66b+
tumor-associated
neutrophils
(TANs),
FoxP3+
regulatory
T
(Tregs),
CD163+
macrophages
(TAMs).
In
addition,
cancers
have
tumor-infiltrating
M1
M2
macrophages,
(Neu),
CD4+
(T-helper),
CD8+
(T-cytotoxic),
eosinophils,
mast
cells.
A
variety
clinical
treatments
linked
cell
infiltration
(ICI)
immunotherapy
receptivity
prognosis.
To
improve
therapeutic
effectiveness
immune-modulating
drugs
a
wider
cancer
patient
population,
their
interactions
must
be
better
understood.
This
study
examines
clinicopathological
effects
overcoming
tumor-mediated
immunosuppression
boost
antitumor
We
successfully
analyzed
predictive
usefulness
alongside
TMB
ICI
scores
identify
cancer's
varied
landscapes.
Traditionally,
was
using
flow
cytometry,
immunohistochemistry,
gene
set
enrichment
analysis
(GSEA),
CIBERSORT,
ESTIMATE,
other
platforms
that
use
integrated
sets
from
previously
published
studies.
also
thoroughly
examined
traditional
limitations
newly
created
unsupervised
clustering
deconvolution
techniques
(SpatialVizScore
ProTICS).
These
methods
predict
outcomes
better.
models
may
individuals
who
benefit
more
adjuvant
or
neoadjuvant
treatment.
Overall,
we
think
significant
contribution
will
greatly
postoperative
follow-up,
therapy,
interventions,
informed
choices
on
customized
medicines.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 14, 2025
The
prognosis
and
treatment
efficacy
of
lung
adenocarcinoma
(LUAD),
a
disease
with
high
incidence,
remains
unsatisfactory.
Identifying
new
biomarkers
therapeutic
targets
for
LUAD
is
essential.
Chromosomal
assembly
factor
1B
(CHAF1B),
p60
component
the
CAF-1
complex,
closely
linked
to
tumor
incidence
cell
proliferation.
However,
CHAF1B's
biological
role
molecular
mechanism
in
remain
unclear.
Here,
CHAF1B
expression
was
examined
using
GEPIA2
UALCAN
databases.
Using
Cancer
Genome
Atlas
(TCGA)
database,
we
analyzed
diagnostic
prognostic
significance
its
association
immune
infiltration
immunological
checkpoints.
Gene
ontology
(GO)
enrichment
single-cell
function
analyses
were
employed
investigate
possible
roles.
Drug
sensitivity
analysis
predicted
effect
on
chemotherapeutic
drug
sensitivity.
We
also
lncRNAs-miRNA-CHAF1B
axis
explore
LUAD.
Preliminary
vitro
studies
qRT-PCR,
CCK8,
Transwell,
glucose,
lactate
metabolism
confirmed
Its
associated
sensitivity,
checkpoints,
infiltration.
that
three
miRNAs
(miR-29c-3p,
miR-145-5p,
miR-1247-5p)
lncRNAs
(AL139287.1,
NEAT1,
SHG1)
may
be
target
regulate
CHAF1B.
In
tests
showed
suppression
decreased
LUAD's
migration,
invasion,
proliferation,
glycolysis.
Overall,
an
innovative
biomarker
Cancer Treatment Reviews,
Journal Year:
2021,
Volume and Issue:
98, P. 102222 - 102222
Published: May 12, 2021
The
neoadjuvant
setting
provides
unquestionable
clinical
benefits
for
high-risk
breast
cancer
(BC)
patients,
mainly
in
terms
of
expansion
locoregional
treatment
options
and
prognostic
stratification.
Additionally,
it
is
also
emerging
as
a
strategical
tool
the
research
field.
In
present
review,
by
focusing
on
HER2-positive
triple-negative
subtypes,
we
examined
role
platform
to
facilitate
rationalize
placement
escalation
strategies,
promote
adoption
biomarker-driven
approaches
investigation
de-escalated
treatments,
foster
conduction
comprehensive
translational
analyses,
thus
ultimately
aiming
at
pursuing
personalization.
solid
pathologic
complete
response
after
therapy,
its
use
surrogate
endpoint
accelerate
drug
approval
process
were
discussed.
this
context,
available
data
escalated
strategies
capable
enhancing
(pCR)
rate
or
improving
prognosis
patients
with
residual
disease
(RD)
treatment,
comprehensively
reviewed.
We
summarized
evidence
regarding
possibility
obtaining
pCR
particular
emphasis
patient
selection.
Pitfalls
dichotomy
pCR/RD
deepened,
alternative/complementary
biomarkers
possible
relevance
regard