A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time DOI Creative Commons
Nasruddeen Al‐Awwal,

Ferris Dweik,

Samira Mahdi

et al.

Pathogens, Journal Year: 2022, Volume and Issue: 11(3), P. 368 - 368

Published: March 17, 2022

Development and deployment of biosensors for the rapid detection 2019 novel severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are utmost importance urgency during this recent outbreak coronavirus pneumonia (COVID-19) caused by SARS-CoV-2 infection, which spread rapidly around world. Cases now confirmed in February 2022 indicate that more than 170 countries worldwide affected. Recent evidence indicates over 430 million cases with 5.92 deaths scattered across globe, United States having 78 920,000 deaths. The US has many China where were first reported late December 2019. During initial China, leaders did not anticipate it could reach whole world, spreading to posing threats global health. objective review is summarize origin COVID-19, its biological nature, comparison other coronaviruses, symptoms, prevention, treatment, potential, available methods detection, post-COVID-19 symptoms.

Language: Английский

The glycosylation in SARS-CoV-2 and its receptor ACE2 DOI Creative Commons
Yanqiu Gong,

Suideng Qin,

Lunzhi Dai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Nov. 15, 2021

Coronavirus disease 2019 (COVID-19), a highly infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 235 million individuals and led to 4.8 deaths worldwide as of October 5 2021. Cryo-electron microscopy topology show that the SARS-CoV-2 genome encodes lots glycosylated proteins, such spike (S), envelope (E), membrane (M), ORF3a which are responsible for host recognition, penetration, binding, recycling pathogenesis. Here we reviewed detections, substrates, biological functions glycosylation in proteins well human receptor ACE2, also summarized approved undergoing therapeutics associated with glycosylation. This review may not only broad understanding viral glycobiology, but provide key clues development new preventive therapeutic methodologies against its variants.

Language: Английский

Citations

172
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses DOI Open Access
Sam M. Murray, M. Azim Ansari, John Frater

et al.

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(5), P. 304 - 316

Published: Dec. 20, 2022

Language: Английский

Citations

120
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases DOI Creative Commons

Sareh Kakavandi,

Iman Zare, Maryam Vaezjalali

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 15, 2023

Coronavirus disease 2019 (COVID-19) is caused by a new member of the Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are structural and non-structural proteins (NSPs) in genome this virus. S, M, H, E proteins, NSPs include accessory replicase proteins. The NSP components SARS-CoV-2 play an important role its infectivity, some them may be pathogenesis chronic diseases, including cancer, coagulation disorders, neurodegenerative cardiovascular diseases. interact with targets such angiotensin-converting enzyme (ACE2) receptor. In addition, can stimulate pathological intracellular signaling pathways triggering transcription factor hypoxia-inducible factor-1 (HIF-1), neuropilin-1 (NRP-1), CD147, Eph receptors, which roles progression diseases like Alzheimer's disease, epilepsy, multiple sclerosis, cancers glioblastoma, lung malignancies, leukemias. Several compounds polyphenols, doxazosin, baricitinib, ruxolitinib could inhibit these interactions. It has been demonstrated that spike protein stronger affinity for human ACE2 than SARS-CoV, leading current study to hypothesize newly produced variant Omicron receptor-binding domain (RBD) binds more strongly primary strain. SARS Middle East (MERS) viruses against have become resistant previous vaccines. Therefore, review recent studies performance vaccines their effects on COVID-19 related vital need deal conditions. This examines potential initiation it anticipated serve effective vaccine or treatment Video Abstract.

Language: Английский

Citations

67
From Alpha to Omicron: How Different Variants of Concern of the SARS-Coronavirus-2 Impacted the World DOI Creative Commons

Mickensone Andre,

Lee-Seng Lau,

Marissa D. Pokharel

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(9), P. 1267 - 1267

Published: Sept. 21, 2023

SARS-CoV-2, the virus that causes COVID-19, is prone to mutations and generation of genetic variants. Since its first outbreak in 2019, SARS-CoV-2 has continually evolved, resulting emergence several lineages variants concern (VOC) have gained more efficient transmission, severity, immune evasion properties. The World Health Organization given these names according letters Greek Alphabet, starting with Alpha (B.1.1.7) variant, which emerged 2020, followed by Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.1.529) This review explores variation among different VOCs how made a global impact on pandemic.

Language: Английский

Citations

55
Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications DOI Open Access

Aakriti Dubey,

Shweta Choudhary,

Pravindra Kumar

et al.

Current Microbiology, Journal Year: 2021, Volume and Issue: 79(1)

Published: Dec. 14, 2021

Language: Английский

Citations

72
Accelerating COVID-19 Research Using Molecular Dynamics Simulation DOI
Aditya K. Padhi, Soumya Lipsa Rath, Timir Tripathi

et al.

The Journal of Physical Chemistry B, Journal Year: 2021, Volume and Issue: 125(32), P. 9078 - 9091

Published: July 28, 2021

The COVID-19 pandemic has emerged as a global medico-socio-economic disaster. Given the lack of effective therapeutics against SARS-CoV-2, scientists are racing to disseminate suggestions for rapidly deployable therapeutic options, including drug repurposing and repositioning strategies. Molecular dynamics (MD) simulations have provided opportunity make rational scientific breakthroughs in time crisis. Advancements these technologies recent years become an indispensable tool studying protein structure, function, dynamics, interactions, discovery. Integrating structural data obtained from high-resolution methods with MD helped comprehending process infection pathogenesis, well SARS-CoV-2 maturation host cells, short duration time. It also guided us identify prioritize targets new chemical entities, repurpose drugs. Here, we discuss how simulation been explored by community accelerate guide translational research on past year. We considered future directions researchers, where can help fill existing gaps research.

Language: Английский

Citations

67
Drug Repurposing for COVID-19: A Review and a Novel Strategy to Identify New Targets and Potential Drug Candidates DOI Creative Commons
Liliana Rodrigues, Renata Bento Cunha,

Tatiana Vassilevskaia

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2723 - 2723

Published: April 23, 2022

In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative agent of disease 2019 (COVID-19) was first identified in province Wuhan, China. Since then, there have been over 400 million confirmed cases and 5.8 deaths by COVID-19 reported worldwide. The urgent need for therapies against SARS-CoV-2 led researchers to use drug repurposing approaches. This strategy allows reduction risks, time, costs associated with development. many cases, a repurposed can enter directly preclinical testing clinical trials, thus accelerating whole discovery process. this work, we will give general overview main developments treatment, focusing on contribution paradigm find effective drugs disease. Finally, present our findings using new that 11 compounds may be potentially COVID-19. To knowledge, seven these never tested are potential candidates vitro vivo studies evaluate their effectiveness treatment.

Language: Английский

Citations

66
Vaccines for COVID-19: A Systematic Review of Immunogenicity, Current Development, and Future Prospects DOI Creative Commons
Zhan Zhang, Qi Shen, Haocai Chang

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 27, 2022

The persistent coronavirus disease 2019 (COVID-19), characterized by severe respiratory syndrome, is caused 2 (SARS-CoV-2), and it poses a major threat to public health all over the world. Currently, optimal COVID-19 management involves effective vaccination. Vaccination known greatly enhance immune response against viral infections reduce transmission of COVID-19. However, although current vaccines offer some benefits, variations other factors demand continuous development eliminate this virus from host. Hence, vaccine research crucial urgent elimination pandemic. Herein, we summarized structural replicatory features SARS-CoV-2, focused on vaccine-mediated prevention strategies like antigen selection, research, application. We also evaluated latest literature extensively reviewed action mechanisms, clinical trial (CT) progresses, advantages, as well disadvantages various candidates SARS-CoV-2. Lastly, discussed treatment, trends, future prospects.

Language: Английский

Citations

59
Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV- 2: An In Silico Approach DOI Open Access

ANM Ansori,

VD Kharisma,

Arli Aditya Parikesit

et al.

Pharmacognosy Journal, Journal Year: 2022, Volume and Issue: 14(1), P. 85 - 90

Published: Feb. 22, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes COVID-19 which responsible for illness infection in humans. The was first identified China 2019 and later spread to other countries worldwide. This study aims identify bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanisms against two SARS-CoV-2 proteases through silico approach. three-dimensional structure of various database examined. Furthermore, all target were analyzed drug, activity prediction, virtual screening, molecular interactions, threedimensional visualization. It aimed determine potential can serve agents fight SARS-CoV-2. Results showed have prospective provide contradict inhibitory mechanisms. In summary, binding results low energy expected ability induce any protein reaction. Therefore, it allows act infection. Key words: Antiviral agent, COVID-19, Garcinia L., approach,

Language: Английский

Citations

58
In silico investigation of phytoconstituents of medicinal herb ‘Piper Longum’ against SARS-CoV-2 by molecular docking and molecular dynamics analysis DOI Creative Commons
Shradha Lakhera, Kamal Devlal, Arabinda Ghosh

et al.

Results in Chemistry, Journal Year: 2021, Volume and Issue: 3, P. 100199 - 100199

Published: Jan. 1, 2021

Unavailability of treatment for the SARS-CoV-2 virus has raised concern among population worldwide. This led to many attempts find alternative options prevent infection disease, including focusing on vaccines and drugs. The use natural products herbal extracts can be a better option in beating boosting up immunity. In present paper, we have done systematic

Language: Английский

Citations

57