Ferroptosis and aerobic training in ageing

Clinical Hemorheology and Microcirculation, Journal Year: 2024, Volume and Issue: 87(3), P. 347 - 366

Published: Jan. 30, 2024

Ferroptosis is a form of programmed cell death that plays significant role in causing several diseases such as heart attack and failure, through alterations fat, amino acid, iron metabolism. Comprehending the regulatory mechanisms ferroptosis signaling critical because it has considerable effect on elderly’s mortality. Conversely, age-related changes substrate metabolism metabolite levels are recognized to give rise obesity. Furthermore, research proposed aging obesity-related may aggravate ferroptosis. The suppression holds potential successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular central nervous system diseases. However, pathologic biological behind function not fully comprehended yet. Physical activity could affect lipid, modulate aim this study showcase current understanding molecular leading discuss physical phenomenon.

Language: Английский

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Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

Cells, Journal Year: 2021, Volume and Issue: 10(9), P. 2359 - 2359

Published: Sept. 8, 2021

Health and lifespan are influenced by dietary nutrients, whose balance is dependent on the supply or demand of each organism. Many studies have shown that an increased carbohydrate–lipid intake plays a critical role in metabolic dysregulation, which impacts longevity. Caenorhabditis elegans has been successfully used as vivo model to study effects several factors, such genetic, environmental, diet, lifestyle molecular mechanisms linked healthspan, lifespan, aging process. There evidence showing causative high glucose different diabetic models; however, precise biological affected specifically carbohydrates lipids, well their links with longevity, remain unknown. Here, we provide overview deleterious caused high-carbohydrate high-lipid diets, signals affect C. elegans; thus, understanding detailed high-glucose- lipid-induced changes whole organisms would allow targeting key regulatory factors ameliorate disorders age-related diseases.

Language: Английский

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Nutrition in Alzheimer’s disease: a review of an underappreciated pathophysiological mechanism

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(10), P. 2257 - 2279

Published: April 7, 2023

Language: Английский

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Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 9, 2024

Abstract Background Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development progression age-related diseases. Bazi Bushen (BZBS), a traditional Chinese medicine used to alleviate frailty, delays biological aging by modulating DNA methylation levels. However, precise mechanism its anti-aging effect remains unclear. In this study, we developed Energy Expenditure Aging Index (EEAI) estimate age. By integrating EEAI transcriptome analysis, aimed explore impact BZBS on dysregulation in naturally mice. Methods We conducted indirect calorimetry analysis five groups mice different ages utilized data construct EEAI. 12 -month-old C57BL/6 J were treated or β-Nicotinamide Mononucleotide (NMN) for 8 months. Micro-CT, Oil Red O staining, calorimetry, RNA sequencing, bioinformatics qRT-PCR performed investigate regulatory effects energy metabolism, glycolipid inflammaging. Results The results revealed that treatment effectively reversed decline expenditure enhanced overall as indicated index derived from metabolism parameters across various ages. Subsequent investigations showed reduced age-induced visceral fat accumulation hepatic lipid droplet aggregation. Transcriptomic perirenal liver pathways, such PPAR signaling pathway, fatty acid oxidation, cholesterol improved glycolysis mitochondrial respiration. Additionally, there was significant improvement inhibiting inflammation-related arachidonic acid-linoleic pathway restraining IL-17 TNF inflammatory pathways activated via senescence secretory phenotype (SASP). Conclusions has potential organs aged maintain homeostasis. This study presents novel clinical therapeutic approaches prevention

Language: Английский

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The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions

E3S Web of Conferences, Journal Year: 2025, Volume and Issue: 608, P. 03004 - 03004

Published: Jan. 1, 2025

A study of the effect high altitude (Tuya-Ashu Pass, 3200 m above sea level and Bishkek, 720 level) on rat metabolism demonstrated significant changes in lipid profile oxidative stress levels after three days exposure to low oxygen availability. There was a increase total cholesterol triglyceride levels, indicating disturbances may be indicative hyperlipidemia. Low density lipoproteins (LDL) increased significantly, while (HDL) decreased which is likely associated with worsening cardiovascular health an risk atherosclerosis. Malondialdehyde (MDA) increased, as result adaptation conditions. Increased activity superoxide dismutase (SOD) catalase enzymes confirms that rats’ bodies are trying adapt by activating free radical defense mechanisms. Oral administration ω-3 fatty acids at dose 300 mg/kg animal body weight once day for 30 leads decrease atherogenic low-density lipoproteins, malondialdehyde, anti-atherogenic high-density catalase.

Language: Английский

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