From Tumor to Bone: Growth Factor Receptors as Key Players in Cancer Metastasis DOI Creative Commons

Khalid S. Mohammad,

Shahid Akhtar Akhund

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(5)

Published: May 13, 2024

This review article explores the intricate correlation between growth factors and bone metastases, which play a crucial role in development of several types malignancies, namely breast, prostate, lung, renal cancers. The focal point our discussion is on receptors for factors, including Epidermal Growth Factor Receptor (EGFR), Transforming Factor-β (TGFβ), Vascular Endothelial (VEGFR), Fibroblast (FGFR). These receptors, are essential cellular activities growth, differentiation, survival, have important involvement spread cancer interactions tumors environment. We discuss underlying mechanisms with specific emphasis interaction factor microenvironment. EGFR signaling specifically enhances process osteoclast formation osteolytic lesions, especially breast lung malignancies. TGFβ both osteoblastic metastases by releasing TGFβ, attracts cells promotes remodeling. element prostate to bones. functions FGFR VEGFR processes tumor angiogenesis, respectively, highlight complex diverse nature these interactions. emphasizes possibility targeted therapeutics targeting interrupt cycle degradation. Therapeutic approaches include focusing VEGF/VEGFR, EGF/EGFR, FGF/FGFR, TGFβ/TGFβR pathways. variety compounds, such as small molecule inhibitors monoclonal antibodies, shown potential interfere tumor-induced alterations bone. text discusses clinical trials preclinical models, offering insights into effectiveness constraints various treatments. Ultimately, this study provides succinct but thorough summary present knowledge treatment strategies focused metastases. highlights significance comprehending microenvironment where bones, well using therapies enhance results patients advancement treating hinges treatments that target relationships malignancies

Language: Английский

Biological and Clinical Aspects of Metastatic Spinal Tumors DOI Open Access
Jakub Litak, Wojciech Czyżewski, Michał Szymoniuk

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4599 - 4599

Published: Sept. 22, 2022

Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine develop the course about 10% malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes order find appropriate, targeted therapeutic options. Thanks continuous research, there appears more detailed knowledge cancer metastasis, but these transformations extremely complicated, e.g., due complexity reactions, variety places where they occur, or participation both tumor cells host transitions. The right target points metastasis mechanisms still being researched; that will help us proper diagnosis as well finding treatment. In this literature review, we described current molecular pathways biomarkers engaged involving spine. We also presented bone-targeted treatment emerging therapies targeting discussed mechanisms.

Language: Английский

Citations

19
Deep learning–based radiomic nomograms for predicting Ki67 expression in prostate cancer DOI Creative Commons

Shuitang Deng,

Jingfeng Ding,

Hui Wang

et al.

BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 8, 2023

Abstract Background To explore the value of a multiparametric magnetic resonance imaging (MRI)-based deep learning model for preoperative prediction Ki67 expression in prostate cancer (PCa). Materials The data 229 patients with PCa from two centers were retrospectively analyzed and divided into training, internal validation, external validation sets. Deep features extracted selected each patient’s MRI (diffusion-weighted imaging, T2-weighted contrast-enhanced T1-weighted sequences) to establish radiomic signature construct models expression. Independent predictive risk factors identified incorporated clinical model, combined obtain joint model. performance multiple deep-learning was then evaluated. Results Seven constructed: one three (the DLRS-Resnet, DLRS-Inception, DLRS-Densenet models), Nomogram-Resnet, Nomogram-Inception, Nomogram-Densenet models). areas under curve (AUCs) testing, sets 0.794, 0.711, 0.75, respectively. AUCs ranged 0.939 0.993. DeLong test revealed that superior ( p < 0.01). DLRS-Resnet inferior Nomogram-Resnet 0.01), whereas remaining did not differ significantly. Conclusion easy-to-use learning–based predicting developed this study can help physicians more detailed prognostic before patient undergoes surgery.

Language: Английский

Citations

11
Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis DOI Creative Commons
Kai Huang,

Linyu Yang,

Yue Ma

et al.

Genes & Diseases, Journal Year: 2025, Volume and Issue: 12(3), P. 101511 - 101511

Published: Jan. 5, 2025

The pathogenesis of neuroblastoma with bone or marrow metastasis (NB-BBM) and its complex immune microenvironment remain poorly elucidated, hampering the advancement effective risk prediction for BBM limiting therapeutic strategies. Feature recognition 142 paraffin-embedded hematoxylin-eosin-stained tumor section images was conducted using a Swin-Transformer pathological histology to predict NB-BBM occurrence. Single-cell transcriptomics identified cell subpopulation (NB3) two tumor-associated macrophage (TAM) subpopulations (SPP1+ TAMs IGHM+ TAMs) closely associated highlighted transketolase (TKT) as key molecular marker metastatic progression in NB. This extensive multi-omics investigation into enhances our understanding single-cell transcriptional dynamics NB beyond existing research, outlining evolution from situ carcinoma through tumorigenesis metastases. Furthermore, exploration specific crucial promoting NB-BBM, presenting new avenues immunotherapy. These insights enhance process facilitate development more diagnostic strategies this aggressive pediatric cancer.

Language: Английский

Citations

0
Molecularly Manipulating Pyrazinoquinoxaline Derivatives to Construct NIR-II AIEgens for Multimodal Phototheranostics of Breast Cancer Bone Metastases DOI
Ping Zheng,

Xueke Yan,

Jun Zhu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123105 - 123105

Published: Jan. 11, 2025

Language: Английский

Citations

0
Metastatic Bone Disease: A Clinical Approach DOI
Edwin Maduakonam Dim, Zihuai He, D. Liu

et al.

Journal of Southeast Asian Orthopaedics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Background: Advances in oncological management have contributed to longer survival of patients, even the presence metastases. Consequently, more patients would be expected present with symptomatic bony The major objectives orthopaedic surgical interventions bone metastases include stabilization impending or actual pathological fractures, restoration mobility and gait, resultant reduction overall morbidity during period cancer patient.Purpose: This review was aimed at producing a synoptic material for ease reference by students, trainees young surgeons who come into contact suffering from metastatic lesions.Methods: A literature on subject diseases done. Information epidemiology, pathophysiology mechanisms metastases, clinical problems concept skeletal related events (SREs), differential diagnoses, diagnostic approach, general principles options treatment, prognosis extracted presented.Conclusions: Metastatic lesions are most common malignant tumours that affect skeleton, these deposits bones increase patients. Appendicular skeleton offers large surface area deposition tumour cells primary sites, including breast, prostate, lung, kidney thyroid, highest incidence coming breast prostate. osseous predispose pain, mechanical instability fractures affected parts. These factors contribute reduced

Language: Английский

Citations

0
Bone Metastases DOI Open Access
Avipsa Hazra, Gowrav Baradwaj,

R. Sushma

et al.

Published: March 3, 2025

Citations

0
Metal ions and nanomaterials for targeted bone cancer immunotherapy DOI Creative Commons
Sen Qin, Yaofeng Hu, Hongbo R. Luo

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Bone cancer remains a significant challenge in oncology, with limited success current therapeutic approaches, particularly immunotherapy. Emerging research highlights the potential of integrating metal ions and nanomaterials for targeted immunotherapy bone cancer. Metal ions, including calcium, magnesium, zinc, play role modulating immune responses within tumor microenvironment, affecting essential pathways necessary activation. Meanwhile, nanomaterials, metallic nanoparticles, offer precise drug delivery system modulation, improving efficacy immunotherapeutic agents. This review explores synergistic effects ion-nanomaterial conjugates, discussing their enhancing cell activation, T-cells macrophages, controlled release. We highlight preclinical advancements treatment using ion-responsive address challenges such as biocompatibility toxicity. Finally, we discuss future prospects these technologies personalized precision medicine, aiming to revolutionize

Language: Английский

Citations

0
Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects DOI Open Access
Florina-Daniela Cojocaru, Vera Bǎlan, Liliana Vereştiuc

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16190 - 16190

Published: Dec. 19, 2022

The need for bone substitutes is a major challenge as the incidence of serious disorders massively increasing, mainly attributed to modern world problems, such obesity, aging global population, and cancer incidence. Bone represents one most significant causes defects, with reserved prognosis regarding effectiveness treatments survival rate. Modern therapies, hyperthermia, immunotherapy, targeted therapy, magnetic seem bring hope treatment in general, particular. Mimicking composition create advanced scaffolds, substitutes, proved be insufficient successful regeneration, special attention should given control changes tissue micro-environment. manipulation by an external field can promising technique this micro-environment, sustain proliferation differentiation osteoblasts, promoting expression some growth factors, and, finally, accelerating new formation. By incorporating stimuli responsive nanocarriers scaffold's architecture, nanoparticles functionalized bioactive molecules, their behavior rigorously controlled under driving, stimulates

Language: Английский

Citations

16
CD44 in Bone Metastasis Development: A Key Player in the Fate Decisions of the Invading Cells? DOI

Noy Shir Zer,

Noa Ben-Ghedalia-Peled, Levi A. Gheber

et al.

Clinical & Experimental Metastasis, Journal Year: 2023, Volume and Issue: 40(2), P. 125 - 135

Published: April 1, 2023

Language: Английский

Citations

10
Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review) DOI Creative Commons

Zixing Kou,

Cun Liu, Wenfeng Zhang

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(5)

Published: April 4, 2024

Compared with primary tumor sites, metastatic sites appear more resistant to treatments and respond differently the treatment regimen. It may be due heterogeneity in microenvironment between tumors. Cancer‑associated fibroblasts (CAFs) are widely present stroma as key components of microenvironment. Primary CAFs (pCAFs) (mCAFs) heterogeneous terms source, activation mode, markers functional phenotypes. They can shape according organ, showing tumors metastases, which affect sensitivity these treatment. was hypothesized that understanding pCAFs mCAFs provide a glimpse into difference outcomes, providing new ideas for improving rate metastasis control various cancers.

Language: Английский

Citations

3