Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive Overview

Viruses, Journal Year: 2022, Volume and Issue: 14(5), P. 1082 - 1082

Published: May 18, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in humans more than two years ago and caused an unprecedented socio-economic burden on all countries around the world. Since then, numerous studies have attempted to identify various mechanisms involved alterations of innate adaptive immunity COVID-19 patients, with ultimate goal finding ways correct pathological changes improve disease outcomes. State-of-the-art research methods made it possible establish precise molecular which new virus uses trigger multisystem inflammatory evade host antiviral immune responses. In this review, we present a comprehensive analysis published data that provide insight into T B cell subsets their phenotypes, accompanying phase SARS-CoV-2 infection. This knowledge might help reveal biomarkers can be utilized recognize case severity early as well additional objective information effective formation SARS-CoV-2-specific predict long-term complications COVID-19, including large variety symptoms termed ‘post-COVID-19 syndrome’.

Language: Английский

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COVID-19 and autoimmune diseases: is there a connection?

Current Opinion in Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 23(2), P. 185 - 192

Published: Jan. 11, 2023

Purpose of review This summarizes current evidence on the potential link between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and autoimmunity. Recent findings Several viral infections are triggers reactive autoimmune diseases by inducing type II IV hypersensitivity reactions. demonstrated that SARS-CoV-2 is not an exception, triggering production tissue-specific autoantibodies during phase disease 2019 (COVID-19) leading to development as long-term complication. The significant immune dysregulation with cytokine storm organ damage observed in patients critical COVID-19 considered main mechanism explaining high levels autoantibodies, which also implicated severity need for intensive care assessment. Multisystem inflammatory children (MIS-C) immune-mediated where recent leads systemic inflammation, already other diseases. Summary Autoimmunity may be a complication SAR-CoV-2 infection. Understanding pathogenesis manifestations might help prevent incidence or exacerbation disorders design better more efficient treatment strategies adult populations.

Language: Английский

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Brain Fog: a Narrative Review of the Most Common Mysterious Cognitive Disorder in COVID-19

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(12), P. 9915 - 9926

Published: Oct. 24, 2023

Language: Английский

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Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 26, 2023

Abstract Objectives To investigate whether the risk of developing an incident autoimmune disease is increased in patients with previous COVID-19 compared to people without COVID-19. Method A cohort was selected from German routine health care data covering 38.9 million individuals. Based on documented diagnoses, we identified individuals polymerase chain reaction (PCR)-confirmed through December 31, 2020. Patients were matched 1:3 control Both groups followed up until June 30, 2021. We used four quarters preceding index date end follow-up analyze onset diseases during post-acute period. Incidence rates (IR) per 1000 person-years calculated for each outcome and patient group. Poisson models deployed estimate incidence rate ratios (IRRs) conditional a diagnosis Results In total, 641,704 included. Comparing (IR=15.05, 95% CI: 14.69-15.42) (IR=10.55, 10.25-10.86), found 42.63% higher likelihood acquiring autoimmunity who had suffered This similar common diseases, such as Hashimoto thyroiditis, rheumatoid arthritis, or Sjögren syndrome. The highest IRR observed vasculitis more severe course at greater diseases. Conclusions SARS-CoV-2 infection associated new-onset after acute phase infection.

Language: Английский

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Autoantibodies against type I interferons in COVID-19 infection: A systematic review and meta-analysis

International Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 130, P. 147 - 152

Published: March 10, 2023

Language: Английский

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