Platelets and Neurodegenerative Diseases: Current Knowledge and Future Perspectives DOI Open Access
Antonella Gallo,

Alice Lipari,

Silvino Di Francesco

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6292 - 6292

Published: June 7, 2024

Platelets have a fundamental role in mediating hemostasis and thrombosis. However, more recently, new idea is making headway, highlighting the importance of platelets as significant actors modulating immune inflammatory responses. In particular, an important development vascular amyloid-b-peptide(ab) deposits, known to play relevant Alzheimer’s disease (AD) through accumulation deposition within frontal cortex hippocampus brain. The involvement pathogenesis AD opens up highly attractive possibility applying antiplatelet therapy for treatment and/or prevention AD, but conclusive results are scarce. Even less about potential mild cognitive impairment (MCI). aim this brief review summarize current knowledge on topic introduce perspectives possible platelet activation therapeutic target both MCI.

Language: Английский

Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients DOI Open Access
Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(20), P. 4414 - 4414

Published: Oct. 20, 2022

Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF PAF-R leads activation pro-inflammatory and prothrombotic pathways have been implicated in onset development atherosclerotic cardiovascular diseases (CVD) inflammatory diseases. Over past four decades, research has focused on identification antagonists target these Research also shown dietary factors such as polar lipids, polyphenols, other nutrient constituents may affect metabolism function through various mechanisms. In this review we focus inhibition how contribute reducing disease risk. We conclude further inhibitors human studies are required investigate modulation prevent lead novel therapeutics.

Language: Английский

Citations

28
Platelet-Derived Exosomes in Atherosclerosis DOI Open Access
Chiara Gardin, Letizia Ferroni, Laura S. Leo

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12546 - 12546

Published: Oct. 19, 2022

Atherosclerosis (AS), the main cause of many cardiovascular diseases (CVDs), is a progressive inflammatory disease characterized by accumulation lipids, fibrous elements, and calcification in innermost layers arteries. The result thickening clogging these vessel walls. Several cell types are directly involved pathological progression AS. Among them, platelets represent link between AS, inflammation, thrombosis. Indeed, besides their pivotal role hemostasis thrombosis, key mediators inflammation at injury sites, where they act regulating function other blood vascular types, including endothelial cells (ECs), leukocytes, smooth muscle (VSMCs). In recent years, increasing evidence has pointed to central platelet-derived extracellular vesicles (P-EVs) modulation AS pathogenesis. However, while microparticles (P-MPs) been significantly investigated same cannot be said for exosomes (P-EXOs). For this reason, reviews aims summarizing isolation methods biological characteristics P-EXOs, discussing involvement intercellular communication pathogenesis Evidence showing how P-EXOs cargo can used as biomarkers also presented review.

Language: Английский

Citations

24
Pan-Immune-Inflammatory Value is Superior to Other Inflammatory Indicators in Predicting Inpatient Major Adverse Cardiovascular Events and Severe Coronary Artery Stenosis after Percutaneous Coronary Intervention in STEMI Patients DOI Creative Commons
Yang Li,

Jiongchao Guo,

Min Chen

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(8)

Published: Aug. 20, 2024

Background: The inflammatory response to atherosclerosis is a process that leads coronary artery disease. Pan-immune-inflammation value (PIV) has emerged as new and simple biomarker of inflammation. However, studies on the predictive power PIV for major adverse cardiovascular events (MACE) or degree stenosis are scarce. We aimed explore ability MACE in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous intervention (PCI) during hospitalization. Methods: This study included 542 who were diagnosed STEMI underwent PCI between 2016 2023 whose other markers measured. Using univariate multivariate logistic regression analysis, risk variables following severe hospitalization assessed create receiver operating characteristic (ROC) curves determine best thresholds markers. Spearman correlation analysis was used evaluate Gensini score (GS). Results: Compared systemic index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), may have greater terms occurrence hospitalized patients. GS strong. Conclusions: superior SII, PLR, NLR predicting inpatient prognosis

Language: Английский

Citations

5
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review DOI Creative Commons
Carlien Rust, Stefanie Malan‐Müller, Leigh Luella van den Heuvel

et al.

Journal of Neuroimmunology, Journal Year: 2023, Volume and Issue: 382, P. 578155 - 578155

Published: July 25, 2023

In this narrative review, we examine the association between gut dysbiosis, neuroinflammation, and stress-linked disorders, including depression, anxiety, post-traumatic stress disorder (PTSD), investigate whether tryptophan (TRP) metabolism platelets play a role in association. The mechanisms underlying aetiology of disorders are complex not yet completely understood. However, potential link chronic inflammation these may potentially be found TRP platelets. By critically analysing existing literature on platelets, microbiome, hope to elicit mediating effects serotonin (5-HT) levels neuroinflammation. We have included studies specifically investigating relation inflammation, neuroinflammation neuropsychiatric disorders. Alteration microbial composition due could contribute increased intestinal permeability, facilitating translocation products, triggering release pro-inflammatory cytokines. This causes become hyperactive secrete 5-HT into plasma. Increased cytokines also lead permeability blood-brain barrier (BBB), allowing inflammatory mediators entry brain, affecting balance such as 5-HT, kynurenic acid (KYNA), quinolinic (QUIN). These alterations possible neurological damage. Furthermore, can cross compromised BBB interact with astrocytes neurons, leading secretion factors, exacerbating conditions brain. resulting from peripheral still unclear, but connection brain through bloodstream significant. Identifying biomarkers plasma that reflect important. review serves foundation for further research blood integration findings protein metabolite markers expand our understanding subject.

Language: Английский

Citations

11
Application Value of Platelet-to-Lymphocyte Ratio as a Novel Indicator in Rheumatoid Arthritis: A Review Based on Clinical Evidence DOI Creative Commons
Shengfeng Liu, Jian Liu,

Xiaoqian Cheng

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7607 - 7617

Published: Oct. 1, 2024

Rheumatoid arthritis (RA) is a chronically progressive autoimmune disease with increasing age-standardized prevalence and incidence of RA worldwide. Its pathological features are persistent synovitis the joint, accompanied by release large number inflammatory cytokines cartilage bone destruction. can lead to joint damage, stiffness swelling, vascular bone-related complications, irreversible disability, which seriously affects patients' life treatment. Early diagnosis treatment enhance quality patients. Platelet-to-lymphocyte ratio (PLR), as common indicator in routine blood tests, has been proposed an systemic inflammation recent years. clinical detection less invasive, economical, rapid simple, applied evaluation variety diseases. Of note, this important assessing activity RA, co-diagnosing detecting subclinical monitoring responses anti-inflammatory therapy. Therefore, review summarizes relationship between PLR relevant mechanisms, further advancing understanding value PLR.

Language: Английский

Citations

4
Brolucizumab and Platelet Activation and Reactivity DOI Creative Commons
Bianka Sobolewska,

Simone Poeschel,

Hubert Kalbacher

et al.

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 6, 2025

Purpose This study explores the potential interaction of brolucizumab with platelets and its effects on platelet activation reactivity, crucial in retinal vasculitis vascular occlusion. Safety concerns remain interest, although showed superior efficacy reduced injection frequency compared to other licensed anti-VEGF agents.

Language: Английский

Citations

0
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival DOI Creative Commons
Linda Kachuri, Geno Guerra, Taishi Nakase

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 14, 2025

Glioma is a highly fatal and heterogeneous brain tumor with few known risk factors. Our study examines genetically predicted variability in blood cell indices relation to glioma survival 3418 cases 8156 controls. We find that increased platelet lymphocyte ratio (PLR) confers an of (odds (OR) = 1.25, p 0.005), especially tumors isocitrate dehydrogenase (IDH) mutations (OR 1.38, 0.007) IDHmut 1p/19q intact (IDHmut-intact OR 1.53, 0.004) tumors. Genetically inferred counts lymphocytes 0.70, neutrophils (IDHmut 0.69, 0.019; IDHmut-intact 0.60, 0.009) show inverse associations risk, which may reflect enhanced immune-surveillance. Considering survival, we observe higher mortality patients (hazard (HR) 1.65, 95% CI: 1.24–2.20), (HR 1.49, 1.13–1.97), eosinophils 1.59, 1.18–2.14). Polygenic scores for traits are also differentially associated 17 immune microenvironment features subtype-specific manner, including signatures related interferon signaling, PD-1 expression, T-cell/Cytotoxic responses. findings highlight immune-mediated susceptibility mechanisms potential disease management implications. aggressive subtype Here, the authors utilise Mendelian Randomisation investigate correlation patients.

Language: Английский

Citations

0
Progress in the application of novel inflammatory indicators in chronic kidney disease DOI Creative Commons

Wei Gao,

Xiangyu Wang, Yulin Zou

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Chronic kidney disease has become a public health problem endangering the of all humans because its high prevalence, mortality and medical burden. The chronic micro-inflammatory state is recognized as significant component CKD, playing key role in progression. Intervening inflammation during course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte systemic immune-inflammatory index are closely associated with meanwhile may serve prognostic monitors all-cause death poor renal prognosis for disease. This article comprehensively reports on mechanisms micro-inflammation relationship between indicators their impact

Language: Английский

Citations

0
A Review of the Correlation between Serum SII, TyG, FAR and the Severity of Coronary Lesions in Patients with Acute Myocardial Infarction DOI

院 高

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1744 - 1753

Published: Jan. 1, 2025

Language: Английский

Citations

0
Insight into the Mechanistic role of Colchicine in Atherosclerosis DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Current Atherosclerosis Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 20, 2025

Language: Английский

Citations

0