Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 27, 2023
Ischemia-reperfusion
(I/R)
injury
refers
to
a
new
caused
by
reperfusion
after
the
restoration
of
ischemic
tissue
or
organ
blood
supply.
Salvianic
acid
A
(danshensu)
is
primary
active
ingredient
extracted
from
Salvia
miltiorrhiza
.
It
has
protective
function
against
I/R
in
cardiovascular
system,
brain,
liver,
kidney,
gastrointestinal
tract,
and
other
organs.
This
article
reviews
evidence
effects
its
potential
mechanisms
action
protection.
The
aim
this
review
investigate
role
treatment
injury,
providing
reference
resource
that
could
facilitate
subsequent
studies.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(16), P. 1750 - 1750
Published: Aug. 12, 2024
Headache
and
visceral
pain
are
common
clinical
painful
conditions,
which
often
co-exist
in
the
same
patients.
Numbers
relative
to
their
co-occurrence
suggest
possible
pathophysiological
mechanisms.
The
aim
of
present
narrative
review
is
describe
most
frequent
headache
associations
discuss
underlying
mechanisms
diagnostic
therapeutic
implications
based
on
recent
evidence
from
international
literature.
conditions
addressed
as
follows:
cardiovascular,
gastrointestinal,
urogenital
areas
primary
such
migraine
tension-type
headache.
comorbidities
involve
following:
cardiac
ischemic
(possible
shared
mechanism
endothelial
dysfunction,
oxidative
stress,
genetic
hormonal
factors),
functional
gastrointestinal
disorders,
particularly
IBS
both
headache,
or
secondary
dysmenorrhea
migraine,
bladder
syndrome
peripheral
central
sensitization
processes).
data
also
show
that
various
pain–headache
characterized
by
more
than
a
simple
sum
symptoms
each
condition
but
complex
interactions
with
enhancement
both,
crucial
for
treatment
purposes.
AJP Heart and Circulatory Physiology,
Journal Year:
2022,
Volume and Issue:
323(5), P. H833 - H844
Published: Sept. 23, 2022
Interleukin
4
(IL4)
and
interleukin
13
(IL13)
are
closely
related
cytokines
that
have
been
classically
attributed
to
type
II
immunity,
namely,
differentiation
of
T-helper
2
(T
JCI Insight,
Journal Year:
2023,
Volume and Issue:
8(16)
Published: July 11, 2023
Myeloid
RNA
regulator
of
Bim-induced
death
(Morrbid)
is
a
newly
identified
leukocyte-specific
long
noncoding
(lncRNA).
However,
the
expression
and
biological
functions
Morrbid
in
cardiomyocytes
heart
disease
are
currently
unclear.
This
study
was
meant
to
determine
role
cardiac
acute
myocardial
infarction
(AMI)
identify
potential
cellular
molecular
mechanisms
involved.
We
found
that
both
human
mouse
could
express
significant
amount
its
increased
with
hypoxia
or
oxidative
stress
as
well
hearts
AMI.
Overexpression
reduced
infarct
size
dysfunction,
whereas
dysfunction
deteriorated
cardiomyocyte-specific
Morrbid-KO
(Morrbidfl/fl/Myh6-Cre)
mice.
had
protective
effect
against
hypoxia-
H2O2-induced
apoptosis;
this
also
confirmed
vivo
after
further
discovered
serpine1
direct
target
gene
involved
Morrbid-mediated
on
cardiomyocytes.
In
summary,
we
have
found,
for
first
time
our
knowledge,
stress-enhanced
lncRNA
protects
from
AMI
via
antiapoptosis
through
serpine1.
may
be
novel
promising
therapeutic
ischemic
diseases
such
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 27, 2023
Ischemia-reperfusion
(I/R)
injury
refers
to
a
new
caused
by
reperfusion
after
the
restoration
of
ischemic
tissue
or
organ
blood
supply.
Salvianic
acid
A
(danshensu)
is
primary
active
ingredient
extracted
from
Salvia
miltiorrhiza
.
It
has
protective
function
against
I/R
in
cardiovascular
system,
brain,
liver,
kidney,
gastrointestinal
tract,
and
other
organs.
This
article
reviews
evidence
effects
its
potential
mechanisms
action
protection.
The
aim
this
review
investigate
role
treatment
injury,
providing
reference
resource
that
could
facilitate
subsequent
studies.
