Российский физиологический журнал им И М Сеченова,
Journal Year:
2023,
Volume and Issue:
109(8), P. 1094 - 1107
Published: Aug. 1, 2023
Reactions
of
pial
arteries
to
exogenous
hydrogen
sulfide
exposure
and
assessment
the
contribution
KATP
BKCa-channels
H2S-mediated
dilation
was
studied
in
rats
different
ages.
Intravital
microphotography
Sprague-Dawley
aged
4
18
months
used
study
reactions
various
diameters
donor
solution
–
sodium
hydrosulfide
(NaHS,
30
μM),
as
well
their
change
with
preliminary
use
potassium
channel
blockers:
(glibenclamide,
10
μM)
BKCa
(tetraethyl
ammonium,
2
mM).
It
found
that
inhibition
increase
constrictor
responses
are
taking
place
age.
Age-related
changes
H2S-induced
dilatory
response
depend
on
size
vessels.
With
age,
there
is
a
decrease
number
dilations
diameter
more
than
20
μm.
At
same
time,
aging
does
not
affect
dilatation
smaller
arteries.
These
disorders
probably
associated
processes
caused
by
activation
channels.
accompanied
increasing
KATP-channels
implementation
less
40
decreases
In
months,
rats,
these
channels
barely
participate
Drug Discovery Today,
Journal Year:
2023,
Volume and Issue:
28(6), P. 103585 - 103585
Published: April 12, 2023
Morphoceuticals
are
a
new
class
of
interventions
that
target
the
setpoints
anatomical
homeostasis
for
efficient,
modular
control
growth
and
form.
Here,
we
focus
on
subclass:
electroceuticals,
which
specifically
cellular
bioelectrical
interface.
Cellular
collectives
in
all
tissues
form
networks
via
ion
channels
gap
junctions
process
morphogenetic
information,
controlling
gene
expression
allowing
cell
to
adaptively
dynamically
pattern
formation.
Recent
progress
understanding
this
physiological
system,
including
predictive
computational
models,
suggests
targeting
interfaces
can
embryogenesis
maintain
shape
against
injury,
senescence
tumorigenesis.
We
propose
roadmap
drug
discovery
focused
manipulating
endogenous
bioelectric
signaling
regenerative
medicine,
cancer
suppression
antiaging
therapeutics.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 30, 2025
ABSTRACT
Crystalline
nephropathy
(CN)
is
characterized
by
deposition
of
microcrystals
within
the
kidney
tubular
microstructure,
specifically
in
renal
cells.
Nephropathic
conditions
have
been
observed
stone
patients
as
nephrocalcinosis,
resulting
from
calcium
phosphate
(CaP)
mainly
tubule.
CaP
trigger
nephrotoxicity
and
cell
death
leading
to
acute
chronic
disease
some
cases
end
stage
disease.
Although
supersaturation
(Ca
2+
)‐
(PO
4
3−
)
ions
urine
was
described
a
main
factor
precise
mechanism
distinguishing
impact
supersaturated
solution
vs
crystalline
substances
unclear.
Here
we
show
differential
effect
preformed
crystal
(as
CaP)
on
degree
type
using
murine
line,
LLCPK1.
We
examined
cellular
[cell
viability,
lactate
dehydrogenase
(LDH)
H
2
O
releases
Annexin+
propidium
iodide
(PI)
staining]
molecular
events
[gene
expressions,
oxidative
endoplasmic
reticular
(ER)
stress]
towards
understanding
CN.
The
results
study
demonstrated
that
exerts
injury
LLCPK1
addition
showed
stronger
necrosis
than
crystals
shown
PI
staining
LDH
.
Overall,
revealed
novel
differentiating
between
insult
mediated
crystals.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(3)
Published: March 1, 2025
Many
complex
traits
and
diseases
show
sex-specific
biases
in
clinical
presentation
prevalence.
To
understand
genetic
architecture
of
cognitive
decline
across
five
domains
(attention,
memory,
executive
function,
language,
visuospatial
function)
global
we
performed
sex-stratified
genome-wide
meta-analysis
3021
older
adults
aged
≥
65
years
(female
=
1545,
male
1476)
from
three
prospective
cohorts.
Gene-based
gene-set
enrichment
analyses
were
conducted
for
each
trait.
We
identified
a
novel
significant
(GWS)
intergenic
locus
memory
males
near
RPS23P3
on
chromosome
4
(rs6851574:
minor
allele
frequency
[MAF]
0.39,
Pmale
4.10E-08,
βmale
0.19;
Pinteraction
3.76E-04).
also
subthreshold
GWS
function
12
females
the
NDUFA12
gene,
involved
oxidative
phosphorylation
(rs11107823:
MAF
0.12,
Pfemale
9.35E-08,
βfemale
0.28;
7.42E-06).
Sex-aware
studies
can
help
identification
loci
enhance
understanding
decline.
Our
single
variants
two
new
associations,
one
females.
The
association
was
observed
with
region
gene
4.
This
has
previously
been
implicated
several
brain
cognition
related
traits,
including
anatomical
aging,
shape,
educational
attainment.
female-specific
which
is
phosphorylation.
Sex-stratified
offer
biological
pathways
aging.
PULMONOLOGIYA,
Journal Year:
2025,
Volume and Issue:
35(2), P. 230 - 240
Published: April 18, 2025
Most
of
the
known
pathogenic
variants
CFTR
gene
are
rare.
Studying
these
allows
us
to
gain
new
knowledge
about
pathogenesis
cystic
fibrosis,
assess
variability
its
manifestations
among
patients,
and
optimize
therapeutic
approaches.
The
aim
was
comprehensively
study
a
rare
variant
G1047S
(c.3139G>A,
p.(Gly1047Ser))
in
two
siblings,
including
description
clinical
picture,
functional
assessment
channel
ex
vivo
by
determining
intestinal
current
measurement
(ICM)
forskolin-induced
swelling
(FIS)
assay
effect
modulators
vitro
organoids.
Methods.
case
history
presented.
ICM
used
membrane
channels
epithelium.
FIS
organoids
patients
sensitivity
ivacaftor,
lumacaftor,
tezacaftor,
elexacaftor.
Results.
missense
is
but
“mild”
since
residual
function
observed.
results
tests
consistent
with
picture:
siblings
have
pancreatic
sufficiency,
no
nutritional
deficiency,
course
disease.
ivacaftor
+
tezacaftor
elexacaftor
therapy
can
be
recommended
for
organoid
model
shows
restoration
activity.
Conclusion.
“mild”,
lower
combination
targeted
drugs
compared
F508del/F508del.
Problems of Balneology Physiotherapy and Exercise Therapy,
Journal Year:
2023,
Volume and Issue:
100(6), P. 6 - 6
Published: Jan. 1, 2023
Life
expectancy
In
Russia
in
2023,
according
to
preliminary
data,
exceeded
73
years,
returning
the
pre-pandemic
level.
The
increase
life
is
associated
both
with
an
improvement
quality
of
medical
care
and
a
more
responsible
attitude
towards
health
citizens,
which
confirmed
by
nutrition,
decrease
alcohol
consumption
number
people
involved
sports.
At
same
time,
there
are
many
signs
aging,
cellular
molecular,
some
main
ones
genome
stability,
telomere
shortening,
epigenetic
alterations,
impaired
proteostasis
nutrient
recognition,
mitochondrial
dysfunction,
depletion
stem
cell
pool
changes
intercellular
interactions,
extracellular
matrix
rigidity,
as
well
retrotransposon
activation
chronic
inflammation.
For
these
reasons,
modern
healthcare,
tasks
preventing
premature
aging
treating
age-related
diseases
becoming
priorities.
