Sumatriptan Mitigates Bleomycin-induced Lung Fibrosis in Male Rats: Involvement of Inflammation, Oxidative Stress and α-SMA DOI

Ayda Bahramifar,

Razieh Mohammad Jafari, Mohammad Sheibani

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102349 - 102349

Published: March 12, 2024

Language: Английский

Mitochondrial quality control in cardiac fibrosis: Epigenetic mechanisms and therapeutic strategies DOI

Li-Chan Lin,

Bin Tu,

Kai Song

et al.

Metabolism, Journal Year: 2023, Volume and Issue: 145, P. 155626 - 155626

Published: June 10, 2023

Language: Английский

Citations

16
The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis DOI Creative Commons

Takanori Hironaka,

Noburo Takizawa,

Yuto Yamauchi

et al.

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 299(3), P. 102934 - 102934

Published: Jan. 20, 2023

Fibrosis is mainly triggered by inflammation in various tissues, such as heart and liver eventually leads to their subsequent dysfunction. characterized the excessive accumulation of extracellular matrix proteins (e.g., collagens) produced myofibroblasts. The well-developed actin cytoskeleton myofibroblasts, one main features differentiating them from resident fibroblasts tissues under inflammatory conditions, contributes maintaining ability produce proteins. However, molecular mechanisms via which promotes production fibrosis-related genes myofibroblasts remain unclear. In this study, we found, single-cell analysis, that developmentally regulated brain protein (drebrin), an actin-binding protein, was specifically expressed cardiac with a fibrotic hearts. Moreover, our immunocytochemistry analysis revealed drebrin promoted formation myocardin-related transcription factor-serum response factor signaling. Comprehensive RNA-Seq expression collagen triple helix repeat containing 1 (Cthrc1), fibrosis-promoting secreted Furthermore, observed profibrotic effects exerted Cthrc1 regulation (hepatic stellate cells). Importantly, demonstrated levels increased human tissues. summary, results indicated due hepatic fibrosis, suggesting therapeutic target molecule for fibrosis.

Language: Английский

Citations

15
The effects of vitamin D on different types of cells DOI

Mária Janubová,

Ingrid Žitňanová

Steroids, Journal Year: 2023, Volume and Issue: 202, P. 109350 - 109350

Published: Dec. 12, 2023

Language: Английский

Citations

14
Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases DOI
Maya Ezzo, Boris Hinz

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 250, P. 108528 - 108528

Published: Sept. 13, 2023

Language: Английский

Citations

13
Sumatriptan Mitigates Bleomycin-induced Lung Fibrosis in Male Rats: Involvement of Inflammation, Oxidative Stress and α-SMA DOI

Ayda Bahramifar,

Razieh Mohammad Jafari, Mohammad Sheibani

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102349 - 102349

Published: March 12, 2024

Language: Английский

Citations

5