The longitudinal biochemical profiling of TBI in a drop weight model of TBI DOI Creative Commons
Ali Yilmaz, Sigal Liraz‐Zaltsman, Esther Shohami

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 14, 2023

Abstract Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age 45. It complex, heterogeneous disease with multifaceted pathophysiology that remains to be elucidated. Metabolomics has potential identify metabolic pathways unique biochemical profiles associated TBI. Herein, we employed longitudinal metabolomics approach study TBI in weight drop mouse model reveal changes pathogenesis, severity, secondary injury. Using proton nuclear magnetic resonance ( 1 H NMR) spectroscopy, biochemically profiled post-mortem from mice suffered mild (N = 25; 13 male 12 female), severe 24; 11 female) sham controls 16; 5 at baseline, day 7 following NMR-based metabolomics, combination bioinformatic analyses, highlights few significant metabolites severity perturbed metabolism related We report concentrations taurine , creatinine adenine dimethylamine histidine N-Acetyl aspartate glucose 1-phosphate are all severity. Longitudinal observation tissue revealed lead distinct profile changes. A multi-class was able classify as well time after estimated 86% accuracy. Further, identified high degree correlation between respective hemisphere (r > 0.84, p < 0.05, Pearson correlation). This underlying While comprehensive, future studies should investigate whether: (a) highlighted here recapitulated sufferers (b) if panel biomarkers also effective less invasively harvested biomatrices, for objective rapid identification prognosis.

Language: Английский

Lactobacillus Helveticus Improves Controlled Cortical Impact Injury-Generated Neurological Aberrations by Remodeling of Gut-Brain Axis Mediators DOI
Tulasi Pasam,

Hara Prasad Padhy,

Manoj P. Dandekar

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Nov. 14, 2024

Language: Английский

Citations

3
The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review DOI Open Access
Antonella Cotoia, Ioannis Alexandros Charitos, Alberto Corriero

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4359 - 4359

Published: Dec. 18, 2024

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), neuroinflammation in TBI. We delineate dual aspects of TBI: immediate mechanical damage (primary injury) subsequent biological processes (secondary exacerbate damage. Dysregulation gut–brain axis emerges as critical factor neuroinflammatory response, emphasizing role GM mediating immune responses. Recent evidence indicates specific including lipids, proteins, probiotics, can influence composition turn modulate neuroinflammation. Moreover, specialized interventions may promote resilience against secondary insults support neurological recovery post-TBI. aims to synthesize current preclinical clinical on potential strategies mitigating pathways, suggesting targeted nutrition health optimization could serve promising therapeutic modalities TBI management.

Language: Английский

Citations

3
Host–Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury DOI Open Access
Yanming Sun, Shuai Wang,

Bingwei Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10820 - 10820

Published: June 28, 2023

Traumatic brain injury refers to the damage caused intracranial tissues by an external force acting on head, leading both immediate and prolonged harmful effects. Neuroinflammatory responses play a critical role in exacerbating primary during acute chronic phases of TBI. Research has demonstrated that numerous neuroinflammatory are mediated through “microbiota–gut–brain axis,” which signifies functional connection between gut microbiota brain. The aryl hydrocarbon receptor (AhR) plays vital facilitating communication host recognizing specific ligands produced directly or indirectly microbiota. Tryptophan (trp), indispensable amino acid animals humans, represents one key endogenous for AhR. metabolites trp have significant effects functioning central nervous system (CNS) activating AHR signalling, thereby establishing bidirectional These interactions immune, metabolic, neural signalling mechanisms. In this review, we emphasize co-metabolism tryptophan pathway following Furthermore, discuss impact these mechanisms underlying processes involved traumatic injury, while also addressing potential future targets intervention.

Language: Английский

Citations

7
Analysis of the brain transcriptome, microbiome and metabolome in ketogenic diet and experimental stroke DOI
Anastasia A. Zharikova, Nadezda V. Andrianova, Д. Н. Силачев

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 571 - 585

Published: Oct. 6, 2024

Language: Английский

Citations

2
The longitudinal biochemical profiling of TBI in a drop weight model of TBI DOI Creative Commons
Ali Yilmaz, Sigal Liraz‐Zaltsman, Esther Shohami

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 14, 2023

Abstract Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age 45. It complex, heterogeneous disease with multifaceted pathophysiology that remains to be elucidated. Metabolomics has potential identify metabolic pathways unique biochemical profiles associated TBI. Herein, we employed longitudinal metabolomics approach study TBI in weight drop mouse model reveal changes pathogenesis, severity, secondary injury. Using proton nuclear magnetic resonance ( 1 H NMR) spectroscopy, biochemically profiled post-mortem from mice suffered mild (N = 25; 13 male 12 female), severe 24; 11 female) sham controls 16; 5 at baseline, day 7 following NMR-based metabolomics, combination bioinformatic analyses, highlights few significant metabolites severity perturbed metabolism related We report concentrations taurine , creatinine adenine dimethylamine histidine N-Acetyl aspartate glucose 1-phosphate are all severity. Longitudinal observation tissue revealed lead distinct profile changes. A multi-class was able classify as well time after estimated 86% accuracy. Further, identified high degree correlation between respective hemisphere (r > 0.84, p < 0.05, Pearson correlation). This underlying While comprehensive, future studies should investigate whether: (a) highlighted here recapitulated sufferers (b) if panel biomarkers also effective less invasively harvested biomatrices, for objective rapid identification prognosis.

Language: Английский

Citations

5