Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 22, 2023
Alzheimer’s disease (AD) is defined as a severe chronic degenerative neurological in human. The pathogenic mechanism of AD has been convincingly elucidated by the “amyloid cascade hypothesis” with main focus pathological accretion β-amyloid (Aβ) peptides outside cell. However, increasing evidence suggests that this hypothesis weak explaining pathogenesis AD. Neuroinflammation crucial development AD, which proven elevated levels inflammatory markers and identification risk genes relevant to innate immune function. Here, we summarize effects microglia-mediated neuroinflammation on focusing temporal spatial changes microglial phenotype, interactions among microglia, Aβ, tau, neurons, prospects recent advances diagnostic therapeutic target
Language: Английский
Citations
142
APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(7-8), P. 943 - 957
Published: April 26, 2023
Language: Английский
Citations
138
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 9, 2023
PANoptosis, a new research hotspot at the moment, is cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur same population. In essence, PANoptosis highly coordinated dynamically balanced programmed inflammatory pathway that combines main features of necroptosis. Many variables, such as infection, injury, or self-defect, may be involved occurrence with assembly activation PANoptosome being most critical. has been linked to development multiple systemic diseases human body, including infectious diseases, cancer, neurodegenerative diseases. Therefore, it necessary clarify process occurrence, regulatory mechanism its relation this paper, we summarized differences relations between three types death, emphatically expounded molecular patterns expectation facilitating application regulation disease treatment.
Language: Английский
Citations
108
Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 177 - 177
Published: Jan. 31, 2024
Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol proinflammatory monomeric C-reactive protein (mCRP). mCRP increases risk AD after stroke and we previously demonstrated that intracerebral induces AD-like dementia mice. Here, used BV2 microglia treated for 24 h presence or absence resveratrol. Cells conditioned media were collected analysis. Lipopolysaccharide (LPS) has also been implicated progression so LPS was as resveratrol-sensitive reference agent. at concentration 50 µg/mL activated nitric oxide pathway NLRP3 inflammasome pathway. Furthermore, induced cyclooxygenase-2 release cytokines. effectively inhibited these changes increased expression antioxidant enzyme genes Cat Sod2. As central defense, hub Sirt1 Nfe2l2 nuclear translocation signal transducer NF-ĸB. Proinflammatory by primary mixed glial cultures protected This work provides mechanistic insight into preventing agents.
Language: Английский
Citations
23
Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2393 - 2408
Published: May 15, 2024
Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer's disease (AD) and Parkinson's disease. Different senescent cell populations secrete senescence-associated secretory phenotypes (SASP), matrix metalloproteinase-3, interleukin (IL)-1α, IL-6, IL-8, which can harm adjacent microglia. Moreover, these cells possess high expression levels of hallmarks (p16 p21) elevated β-galactosidase activity in vitro vivo ND models. These contribute to the deposition β-amyloid tau-protein tangles. Selective clearance SASP regulation by inhibiting p38/mitogen-activated protein kinase nuclear factor kappa B signaling attenuate load prevent tangle deposition, thereby improving cognitive performance AD mouse In addition, telomere shortening, a biomarker, is associated with increased risks. Telomere dysfunction causes senescence, stimulating tumor necrosis factor-α, IL-1β secretions. The forced telomerase activators prevents yielding considerable neuroprotective effects. This review elucidates mechanism pathogenesis, suggesting strategies eliminate or restore normal phenotype for treating such diseases.
Language: Английский
Citations
20
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 5, 2025
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. integration novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, artificial intelligence have significantly expedited the development groundbreaking drugs, effectively addressing obstacles associated with their character, such as rapid clearance degradation, necessitating subcutaneous injection leading increasing patient discomfort, ultimately advancing translational research efforts. Peptides are presently employed in management diagnosis diverse array medical conditions, diabetes mellitus, weight loss, oncology, rare diseases, additionally garnering interest facilitating targeted platforms advancement vaccines. This paper provides an overview present market clinical trial progress therapeutics, platforms, It examines key areas through literature analysis emphasizes structural modification principles well recent advancements screening, design, technologies. accelerated including peptide-drug complexes, new vaccines, innovative diagnostic reagents, has potential promote era precise customization disease therapeutic schedule.
Language: Английский
Citations
5
Immunological Reviews, Journal Year: 2025, Volume and Issue: 329(1)
Published: Jan. 1, 2025
ABSTRACT Z‐nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z‐conformation. Upon sensing, ZBP1 triggers activation, inflammation, and programmed cell death during viral infections, mice development, inflammation‐associated diseases. The Zα domains of sense promote RIP‐homotypic interaction motif (RHIM)‐dependent signaling complex assembly to mount inflammation. studies on spurred understanding the role Z‐form RNA DNA cellular physiological functions. In particular, short genomic segments, endogenous retroviral elements, 3′UTR regions are likely sources Z‐RNAs that orchestrate Recent seminal identify intriguing association with adenosine deaminase acting RNA‐1 (ADAR1), cyclic GMP‐AMP synthase (cGAS) regulating aberrant chronic cancer. Thus, attractive target aid development specific therapeutic regimes for disease biology. Here, we discuss Z‐RNA activation death, Also, how coordinates intracellular perturbations homeostasis, formation regulate diseases
Language: Английский
Citations
2
Translational research, Journal Year: 2022, Volume and Issue: 254, P. 1 - 12
Published: Sept. 6, 2022
Language: Английский
Citations
53
Theranostics, Journal Year: 2023, Volume and Issue: 14(2), P. 640 - 661
Published: Dec. 26, 2023
Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing to eliminating cells and influencing treatment outcomes. The application of RCD marked by its potential targeted therapy immunotherapy. As type RCD, PANoptosis has emerged as unique form programmed (PCD) characterized features pyroptosis, apoptosis, necroptosis but cannot be fully explained any these pathways alone. It regulated multi-protein complex called the PANoptosome. relatively new concept first described 2019, been shown play role many diseases, including cancer, infection, inflammation. This study reviews PCD particularly emergence implication developing therapeutic strategies for cancer. Studies have that characterization patterns can predict survival response immunotherapy chemotherapy, highlighting used target treatment. also plays limiting spread cells. allows elimination multiple address various challenges treatment, drug resistance immune evasion. Moreover, active investigation mechanisms agents induce likely yield effective treatments improve patient Research on still ongoing, it rapidly evolving field with lead
Language: Английский
Citations
37
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: April 27, 2023
Abstract Alzheimer’s disease (AD) is characterized as a distinct onset and progression of cognitive functional decline associated with age, well specific neuropathology. It has been discovered that glutamine (Gln) metabolism plays crucial role in cancer. However, full investigation its still missing. This study intended to find confirm potential Gln-related genes AD using bioinformatics analysis. The discovery GlnMgs was made possible by the intersection WGCNA test 26 Gln-metabolism (GlnMgs). GlnMgs’ putative biological functions pathways were identified GSVA. LASSO method then used identify hub diagnostic efficiency four identifying AD. association between clinical characteristics also studied. Finally, GSE63060 utilized levels expression GlnMgs. Four (ATP5H, NDUFAB1, PFN2, SPHKAP). For function analysis, cell fate specification, atrioventricular canal development, neuron specification emphasized. ability differentiating exhibited good value. are linked They shed light on new biomarkers for tracking progression.
Language: Английский
Citations
30