Pharmacological mechanism of action of Lianhua Qingwen in the treatment of COVID‐19 and facial neuritis DOI Creative Commons

Guang‐Jin Li,

Zhi‐Hong Hao,

H J Wang

et al.

World Journal of Otorhinolaryngology - Head and Neck Surgery, Journal Year: 2024, Volume and Issue: 11(1), P. 102 - 115

Published: May 30, 2024

Abstract Objective Coronavirus disease‐2019 (COVID‐19) can cause not only respiratory symptoms but also facial paralysis. Lianhua Qingwen (LHQW) has been reported to have therapeutic effects on COVID‐19 and neuritis (FN). We explored the potential mechanism of LHQW in treatment FN through a network‐pharmacology approach. Methods Active compounds relevant targets were obtained from databases Traditional Chinese Medicine Systems Pharmacology Database, HERB, UniProt Knowledge Base, SwissADME, Swiss Target Prediction. Disease acquired Gene Cards. Database For Annotation, Visualization And Integrated Discovery Metascape used search biological functions intersecting targets. After identifying core their corresponding ingredients, KEGG Mapper analyzes localization key pathways. AutoDock employed conduct molecular docking ingredients. Results four genes: interleukin (IL)‐8, IL‐1B, IL‐6, tumor necrosis factor (TNF)‐α. searching revealed anti‐inflammatory antiviral may be related action aleo‐emodin, hyperforin, kaempferol, luteolin, quercetin these genes by regulating pathways IL‐17 NOD‐like receptor. The molecular‐docking results active ingredients showed good binding activity between receptors ligands. Conclusions uncovered targets, for coinfection. Our data provide theoretical basis further exploration FN.

Language: Английский

Medicinal Plants Used for Anxiety, Depression, or Stress Treatment: An Update DOI Creative Commons

Maša Kenda,

Nina Kočevar Glavač,

Milan Nagy

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6021 - 6021

Published: Sept. 15, 2022

Depression, anxiety, stress, and other mental disorders, which are on the rise worldwide, indications that pharmacological therapy can have serious adverse effects, is why many patients prefer to use herbal products treat these symptoms. Here, we reviewed plants derived from them commonly used for above indications, focusing clinical data safety profiles. While lavender, hops, maypop, lemon balm, valerian consistently been shown in trials relieve mild forms of neurological particularly depression, currently available do not fully support peppermint anxiety disorders depression. Recent studies saffron depression; however, its toxicological profile raises concerns. St. John’s wort effective alleviating moderate careful necessary due possible interactions with drugs. In conclusion, more needed validate mechanism action so be successfully safely alleviate or eliminate various disorders.

Language: Английский

Citations

61
Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis DOI

Qiancheng Mao,

Hongxiu Zhang,

Zhe Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155510 - 155510

Published: March 11, 2024

Language: Английский

Citations

9
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID DOI Creative Commons
A. Satyanarayan Naidu, Chin‐Kun Wang, Pingfan Rao

et al.

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

Citations

8
The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review DOI Creative Commons
Junting Huang, Yuxuan Fan, Yongshun Wang

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract Some of the millions patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have developed new sequelae after recovering from initial disease, termed post-acute disease 2019 (PASC). One symptom is anxiety, which likely due to three etiologies: brain structural changes, neuroendocrine disruption, and neurotransmitter alterations. This review provides an overview current literature on pathophysiological pathways linking as well possible mechanisms action in increasingly scrutinized treatment method, enhanced external counter-pulsation (EECP), able alleviate anxiety. SARS-CoV-2 triggers increased inflammatory cytokine production, oxidative stress; these processes contribute aforementioned etiologies. The potential approach EECP, involving sequenced inflation deflation specifically-placed airbags, has become increasing interest, it been found PASC-associated anxiety by improving patient cardiovascular function. These functional improvements were achieved EECP stimulating anti-inflammatory pro-angiogenic processes, endothelial cell function coronary blood flow, partially via counteracting against negative effects infection renin–angiotensin–aldosterone system. Therefore, could promote both psychosomatic cardiac rehabilitation. Further research, though, still needed fully determine its benefits mechanism action.

Language: Английский

Citations

0
Nutrition and Dietary Patterns: Effects on Brain Function DOI Open Access
Roser Granero, Gemma Guillazo‐Blanch

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1169 - 1169

Published: March 28, 2025

Dietary habits are strongly associated with neuropsychological functioning [...].

Language: Английский

Citations

0
Integrated metabolome and transcriptome analyses revealed key cytochrome P450 genes involved in the biosynthesis of oleanane-type saponins in Hedera helix L. DOI
Yuedong He, Jing Zhang,

Yuewei He

et al.

Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109818 - 109818

Published: March 1, 2025

Language: Английский

Citations

0
A Randomized Placebo‐Controlled Clinical Trial Exploring the Short‐Term Cognitive and Cerebrovascular Effects of Consuming Peppermint Tea: A Mediation Study DOI Creative Commons

Luka Netzler,

Brian Lovell

Human Psychopharmacology Clinical and Experimental, Journal Year: 2025, Volume and Issue: 40(3)

Published: April 6, 2025

ABSTRACT The cognitive‐enhancing effects of peppermint have been widely reported. Vasodilation, causing an increase in cerebral blood flow (CBF) the prefrontal cortex, has implicated as a possible mediator. We tested this here. A total N = 25 individuals, all aged over 18 years, were recruited via convenience sampling. randomized, single blind placebo‐controlled, independent groups design was used to assess whether (peppermint vs. placebo control) could be differentiated with respect change cognition, assessed computerized battery, and flow, Near‐Infrared‐Spectroscopy (NIRS), from pre‐post intervention. Groups disparities both cognitive cerebrovascular scores (from intervention) emerged. Improvements performance better group. Increases hemodynamic activity, indexed by Oxygenated (Oxy‐Hb) Total hemoglobin (Total‐Hb), also greater Cerebrovascular changes pre‐to post‐intervention unrelated same period, ruling out mediation effects. In conclusion, 200 mL peppermint, consumed tea, effectively boosted cognition otherwise healthy adults. Increased however, did not mediate peppermint. Future research incorporating larger samples exploring other neurophysiological mediators is encouraged.

Language: Английский

Citations

0
The cardioprotective effects of acteoside in myocardial ischemia reperfusion injury and the underlying mechanism DOI Creative Commons
Jing Li, Yuxin Guo, Yang Yang

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 26, 2025

Language: Английский

Citations

0
Antibacterial and anti-coronavirus investigation of selected Senegalese plant species according to an ethnobotanical survey DOI
Abda Ba, Vincent Roumy, Malak Al Ibrahim

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118070 - 118070

Published: March 21, 2024

Language: Английский

Citations

3
Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways DOI Open Access

JINGLONG CAO,

Shumei Li,

TONG ZHANG

et al.

Biocell, Journal Year: 2024, Volume and Issue: 48(2), P. 313 - 325

Published: Jan. 1, 2024

Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity.However, its precise molecular mechanism in cancer cells still unclear.This study investigated effect of Val on gastric (GC) and potential mechanism.Methods: Cell viability examined by CCK-8 assay.Cell cycle, apoptosis, Reactive oxygen species (ROS) level were analyzed flow cytometry.The migration AGS transwell wound-healing assay.The expression levels proteins western blot.Results: The cell assay results demonstrated that significantly decreased GC viability.Apoptosis revealed induced mitochondria-dependent apoptosis through Bad/Bcl-2/ cyto-c/cle-casp-3/cle-PARP pathways.Further exploration found increasing phosphorylated p38 mitogen-activated protein kinase (p-p38), c-Jun N-terminal (p-JNK), Inhibitor kappa B alpha (IκB-α) decreasing extracellular signal-regulated (p-ERK), signal transducer activator transcription 3 (p-STAT3), nuclear factor kappa-B (NF-κB) proteins; these reversed (MAPK) inhibitor.Furthermore, G2/M phase arrest downregulating (p-AKT).Moreover, inhibition p-GSK-3β β-catenin.In addition, promoted ROS accumulation cells.Further investigation Val-induced arrested inhibited migration, signaling pathways related to expressions scavenger, N-acetyl-L-cysteine. Conclusion: ROS-mediated MAPK/STAT3/NF-κB, AKT/Cyclin B/CDK1/2, GSK-3β/β-catenin cells.

Language: Английский

Citations

2