Umbilical cord MSC‐derived exosomes improve alveolar macrophage function and reduce LPS‐induced acute lung injury DOI
Enhai Cui, Lu Lv, Bin Wang

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 125(2)

Published: Jan. 15, 2024

Abstract Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical clinical studies as potential for ALI other lung‐related conditions due their immunomodulatory properties ability regenerate various cell types. The present study focuses on analyzing the role of umbilical cord MSC (UC‐MSC))‐derived exosomes reducing lipopolysaccharide‐induced investigating mechanism involved. demonstrates UC‐MSC‐derived effectively improved metabolic function alveolar macrophages promoted shift an anti‐inflammatory phenotype, leading reduction ALI. findings also suggest creating three‐dimensional microspheres from MSCs first enhance effectiveness exosomes. Further research needed fully understand action optimize therapeutic secretome conditions.

Language: Английский

Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature DOI Creative Commons
Yusuke Shimizu, Edward Hosea Ntege, Hiroshi Sunami

et al.

Regenerative Therapy, Journal Year: 2022, Volume and Issue: 21, P. 527 - 539

Published: Oct. 31, 2022

Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities, it remains an economic burden to individuals the society. Alopecia attributable varied mechanisms features a multifactorial predisposition, available conventional interventions have limitations. Thus, therapeutic strategies for alopecia in regenerative medicine are currently being explored, increasing evidence suggesting that mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, blood-derived platelet-rich plasma therapies potential treatment options. In this review, we searched Cochrane Library, MEDLINE (PubMed), EMBASE, Scopus using various combinations of terms, such as “stem cell,” “alopecia,” “hair loss,” “Androgenetic alopecia,” “male-pattern hair “female-pattern “regenerative growth,” “cell therapy,” “mesenchymal cells,” “MSC-derived extracellular vesicles,” exosomes,” “platelet-rich plasma” summarized most promising treatments alopecia. Moreover, further opportunities improving efficacy innovative promoting clinical application were discussed.

Language: Английский

Citations

73
Mesenchymal Stromal Cells as a Driver of Inflammaging DOI Open Access
Svetlana Lyamina, Denis Baranovskii,

Ekaterina Kozhevnikova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6372 - 6372

Published: March 28, 2023

Life expectancy and age-related diseases burden increased significantly over the past few decades. Age-related conditions are commonly discussed in a very limited paradigm of depleted cellular proliferation maturation with exponential accumulation senescent cells. However, most recent evidence showed that majority age-associated ailments, i.e., diabetes mellitus, cardiovascular neurodegeneration. These closely associated tissue nonspecific inflammation triggered controlled by mesenchymal stromal cell secretion. Mesenchymal cells (MSCs) known as common type for therapeutic approaches clinical practice. Side effects complications MSC-based treatments interest MSCs secretome an alternative concept validation tests regenerative medicine. The data also proposed it ideal tool cell-free therapy engineering. was shown to hold role ‘key-driver’ inflammaging. We aimed review immunomodulatory MSCs-secretome during senescence provide eventual insight into interpretation its beneficial biological actions inflammaging-associated diseases.

Language: Английский

Citations

30
Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use DOI Creative Commons
Vitale Miceli, Giovanni Zito, Matteo Bulati

et al.

World Journal of Stem Cells, Journal Year: 2023, Volume and Issue: 15(5), P. 400 - 420

Published: May 25, 2023

Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and therefore been extensively investigated in preclinical studies of regenerative medicine. However, while MSCs to be safe as a cellular treatment, they usually therapeutically ineffective human diseases. In fact, many clinical trials it has that moderate or poor efficacy. This inefficacy appears ascribable primarily the heterogeneity MSCs. Recently, specific priming strategies used improve properties this review, we explore literature on principal approaches enhance We found different direct effects toward pathological processes. Particularly, hypoxic can for treatment acute diseases, inflammatory cytokines mainly prime order treat chronic immune-related disorders. The shift approach from regeneration inflammation implies, MSCs, production functional factors stimulate anti-inflammatory pathways. opportunity fine-tune through could conceivably pave way optimizing their potential.

Language: Английский

Citations

24
Mesenchymal stem cells biological and biotechnological advances: Implications for clinical applications DOI

Jana Pharoun,

Jana Berro,

Jeanine Sobh

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 977, P. 176719 - 176719

Published: June 6, 2024

Language: Английский

Citations

11
Application of dental pulp stem cells for bone regeneration DOI Creative Commons
Ye Liu, Wei Xiong, Junyi Li

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 29, 2024

Bone defects resulting from severe trauma, tumors, inflammation, and other factors are increasingly prevalent. Stem cell-based therapies have emerged as a promising alternative. Dental pulp stem cells (DPSCs), sourced dental pulp, garnered significant attention owing to their ready accessibility minimal collection-associated risks. Ongoing investigations into DPSCs revealed potential undergo osteogenic differentiation capacity secrete diverse array of ontogenetic components, such extracellular vesicles cell lysates. This comprehensive review article aims provide an in-depth analysis secretory emphasizing extraction techniques utilization while elucidating the intricate mechanisms governing bone regeneration. Furthermore, we explore merits demerits cell-free therapeutic modalities, well discuss prospects, opportunities, inherent challenges associated with DPSC therapy in context

Language: Английский

Citations

9
Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review DOI Creative Commons
Siddharth Shah, Hadeel M. Mansour, Brandon Lucke‐Wold

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 42 - 42

Published: Jan. 3, 2025

Huntington’s disease (HD) is an inherited neurodegenerative characterized by uncontrolled movements, emotional disturbances, and progressive cognitive impairment. It estimated to affect 4.3 10.6 per 100,000 people worldwide, the mean prevalence rate among all published studies, reviews, genetic HD registries 5.7 100,000. A key feature of loss striatal neurons cortical atrophy. Although there no cure at present, discovery gene causing has brought us into a new DNA era therapeutic advances for several neurological disorders. PubMed was systematically searched using three search strings: ‘“Huntington disease” + “stem cell”’, ‘”Huntington Mesenchymal stromal cell’, “induced pluripotent stem cell”’. For each string, results were categorized based on cell type, papers that included clinical analysis as well. The data extracted up 2024. We did not include other databases in our have comparable systematic review literature topic. collected analyzed used critical interpretation present review. Data are presented chronologically studies published. Therapeutic strategies cells drawn lot interest possible therapies. Recent research indicates NSCs been most often utilized type treating HD. generated from variety sources, including patients’ somatic brain itself. There strong evidence supporting transplantation or their derivatives animal models, even if stem-cell-based preclinical trials still early stages. Current treatment only aims relieving symptoms rather than pathogenesis disease. models shown promise improving motor functions, therapy faces many challenges disadvantages immunosuppression immunorejection well ethical, technical, safety concerns. Further required definitive conclusion.

Language: Английский

Citations

1
Role of Mesenchymal Stem Cells and Their Paracrine Mediators in Macrophage Polarization: An Approach to Reduce Inflammation in Osteoarthritis DOI Open Access
Sree Samanvitha Kuppa, Hyung Keun Kim, Ju Yeon Kang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13016 - 13016

Published: Oct. 27, 2022

Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes deterioration cartilage, bone remodeling, formation osteophytes, meniscal damage, and synovial inflammation (synovitis). The synovium primary site in OA frequently characterized by hyperplasia lining infiltration cells, primarily macrophages. Macrophages play crucial role early response through production several cytokines, chemokines, growth factors, proteinases. These pro-inflammatory mediators are activators numerous signaling pathways trigger other cytokines to further recruit more macrophages joint, ultimately leading pain disease progression. Very few therapeutic alternatives available for treating due condition's low self-healing capacity lack clear diagnostic biomarkers. In this review, we opted explore immunomodulatory properties mesenchymal stem cells (MSCs) their paracrine mediators-dependent as intervention OA, with focus on practicality polarizing suppression M1 enhancement M2 can significantly reduce symptoms.

Language: Английский

Citations

29
Three-dimensional culture conditioned bone marrow MSC secretome accelerates wound healing in a burn injury mouse model DOI
Prakash Gangadaran,

Eun Jung Oh,

Ramya Lakshmi Rajendran

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 673, P. 87 - 95

Published: May 23, 2023

Language: Английский

Citations

23
Wharton’s jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications DOI Creative Commons

Hana Drobiova,

Sardar Sindhu,

Rasheed Ahmad

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: June 27, 2023

Accumulating evidence indicates that most primary Wharton’s jelly mesenchymal stem cells (WJ-MSCs) therapeutic potential is due to their paracrine activity, i.e., ability modulate microenvironment by releasing bioactive molecules and factors collectively known as secretome. These can either be released directly into the surrounding or embedded within membrane-bound extracellular nano-sized (usually 30–150 nm) messenger particles vesicles of endosomal origin with specific route biogenesis, exosomes carried relatively larger (100 nm–1 μm) formed outward blebbing plasma membrane called microvesicles (MVs); MVs are (EVs). The found in secretome various types, including cytokines, chemokines, cytoskeletal proteins, integrins, growth factors, angiogenic mediators, hormones, metabolites, regulatory nucleic acid molecules. As expected, performs different biological functions, such immunomodulation, tissue replenishment, cellular homeostasis, besides possessing anti-inflammatory anti-fibrotic effects. This review highlights current advances research on WJ-MSCs’ its prospective clinical applications.

Language: Английский

Citations

23
Enhanced Drug Delivery System Using Mesenchymal Stem Cells and Membrane-Coated Nanoparticles DOI Creative Commons
Shubham Joshi, Sarah Allabun, Stephen Ojo

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2130 - 2130

Published: Feb. 24, 2023

Mesenchymal stem cells (MSCs) have newly developed as a potential drug delivery system. MSC-based systems (MSCs-DDS) made significant strides in the treatment of several illnesses, shown by plethora research. However, this area research rapidly develops, issues with technique emerged, most often result its intrinsic limits. To increase effectiveness and security system, cutting-edge technologies are being concurrently. advancement MSC applicability clinical practice is severely hampered absence standardized methodologies for assessing cell safety, effectiveness, biodistribution. In work, biodistribution systemic safety MSCs highlighted we assess status therapy at time. We also examine underlying mechanisms to better understand risks tumor initiation propagation. Methods explored, well pharmacokinetics pharmacodynamics therapies. highlight various promising technologies, such nanotechnology, genome engineering technology, biomimetic enhance MSC-DDS. For statistical analysis, used analysis variance (ANOVA), Kaplan Meier, log-rank tests. created shared DDS medication distribution network using an extended enhanced optimization approach called particle swarm (E-PSO). identify considerable untapped future paths, use gene medication, membrane-coated nanoparticles, delivery.

Language: Английский

Citations

22