Incorporating Real‐World Variability in Clinical IBD Research

Journal of Evaluation in Clinical Practice, Journal Year: 2025, Volume and Issue: 31(4)

Published: May 6, 2025

Language: Английский

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Ernährung – Physiologie und Pathophysiologie

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 85 - 177

Published: Jan. 1, 2025

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The Role of Intestinal Microbiota in Celiac Disease and Further Therapeutic Perspectives

Life, Journal Year: 2023, Volume and Issue: 13(10), P. 2039 - 2039

Published: Oct. 11, 2023

Celiac disease (CD) is an immune-mediated enteropathy caused by exposure to gluten and related prolamins in genetically susceptible individuals. It a complex genetic disorder with multiple contributing genes. Linkage studies have identified several genomic regions that probably contain CD susceptibility The most important factors are HLA-DQ2 DQ8. Several known environmental triggers promote the onset of at any age after introduction individuals background, such as viral infections intestinal dysbiosis. Recent publications described interference microbiome metabolism, modulation local immune reactions, maintaining normal gut permeability. These results promoted further lines research on benefit probiotic administration prevent or alleviate clinical symptoms along gluten-free diet (GFD). relationship between changes incompletely understood, still being subject current research. This narrative review analyzes interplay factors, alterations, course CD. Furthermore, this sets out discuss if microflora pre- probiotics GFD could represent reliable therapeutic target for celiac patients.

Language: Английский

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Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 681 - 681

Published: Feb. 28, 2024

Dysbiosis of the microbiota in gastrointestinal tract can induce development gynaecological tumours, particularly postmenopausal women, by causing DNA damage and alterations metabolite metabolism. also complicates cancer treatment influencing body’s immune response disrupting sensitivity to chemotherapy drugs. Therefore, it is crucial maintain homeostasis gut through effective use food components that affect its structure. Recent studies have shown polyphenols, which are likely be most important secondary metabolites produced plants, exhibit prebiotic properties. They structure synthesis metabolites. In this review, we summarise current state knowledge, focusing on impact polyphenols endometrial cancer, emphasising polyphenol consumption leads beneficial modifications microbiota.

Language: Английский

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Refined Enterotyping Reveals Dysbiosis in Global Fecal Metagenomes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract Enterotypes describe human fecal microbiomes grouped by similarity into clusters of microbial community composition, often associated with disease, medications, diet, and lifestyle. Numbers determinants enterotypes have been derived diverse frameworks applied to cohorts that lack diversity or inter-cohort comparability. To overcome these limitations, we selected 16,772 metagenomes collected from 38 countries revisit the using state-of-the-art fuzzy clustering found robust regardless underlying taxonomy, consistent previous findings. Quantifying strength enterotype classifications enriched landscape, also reflecting some continuity compositions. As classification was patient’s health status, established an “Enterotype Dysbiosis Score” (EDS) as a latent covariate for various diseases. This global study confirms enterotypes, reveals dysbiosis signal within enables online “Enterotyper” tool, allowing reproducible analysis in future studies. Graphical

Language: Английский

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Effects of a 217‐km mountain ultramarathon on the gut microbiota of an obese runner: A case report

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(16)

Published: Aug. 1, 2024

Abstract Obesity is characterized by specific changes in the composition of gut microbiota (GM). Exercise can contribute to modulation GM. This first case study analyze and metabolism GM an obese runner a single‐stage mountain ultramarathon (MUM) with mileage 217 km. Fecal samples were collected 7 days before race (T0), 15 min after end (T1), (T2). was analyzed real‐time PCR shotgun sequencing. We observed decrease Bacillota/Bacteroidota ratio α‐diversity race. After 217‐km MUM, we symbiont microorganisms notable increase harmful bacteria. In conclusion, found that MUM may have contributed intestinal dysbiosis runner.

Language: Английский

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Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: March 21, 2024

The gut microbiota is recognized as a regulator of brain development and behavioral outcomes during childhood. Nonetheless, associations between the behavior are often inconsistent among studies in humans, perhaps because many host-microbe relationships vary widely individuals. This study aims to stratify children based on their composition (i.e., clusters) identify novel microbiome cluster-specific stool metabolomic pathways child outcomes. Stool samples were collected from community sample 248 typically developing (3-5 years). was analyzed using 16S sequencing while LC-MS/MS used for untargeted metabolomics. Parent-reported Adaptive Skills, Internalizing, Externalizing, Behavioral Symptoms, Developmental Social Disorders) assessed Behavior Assessment System Children (BASC-2). grouped Dirichlet multinomial method, after which differences metabolome investigated. Four different clusters identified, where cluster enriched both Bacteroides Bifidobacterium (Ba2) had most distinct metabolome. characterized by high abundance (Bif), well Ba2, associated with lower Skill scores its subcomponent Skills. Cluster Ba2 also significantly histidine urocanate turnover, turn cluster-dependent manner. Finally, increased levels compounds involved Galactose metabolism stachyose, raffinose, alpha-D-glucose), alpha-D-glucose Daily Living ability perform basic everyday tasks) These data show microbiota, metabolites, preschool-aged children. Our results support concept that cluster-based groupings could be develop more personalized interventions Video Abstract.

Language: Английский

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Characteristics of Gut Microbiota in Rosacea Patients—A Cross-Sectional, Controlled Pilot Study

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 585 - 585

Published: May 1, 2024

Background: Recent studies have suggested a possible connection between rosacea and patients’ gut microbiota. Objective: To investigate the differences in fecal microbial profiles patients with healthy controls. Methods: Gut microbiota of 54 (RP) were analyzed using MiSeq 16S rRNA sequencing. Enterotypes, Firmicutes/Bacteroides (F/B) ratio, significance alpha beta diversity, differential abundance analysis (DAA) calculated compared age- gender-matched controls (CP, n = 50). Results: Significant changes enterotypes F/B ratio observed RP CP (p 0.017 p 0.002, respectively). The showed decreased richness diversity to (Shannon 0.012, inverse Simpson 0.034). Beta also differed both groups (PERMANOVA, 0.006). Fourteen significantly different taxa detected according DAA. Faecalibacterium prausnitzii (coef. −0.0800, 0.008), Lachnoospiraceae ND 3007 group sp. −0.073, < 0.001), Ruminococcaceae −0.072, 0.015) decreased; Oscillobacter 0.023, 0.031), Flavonifractor plautii 0.011, 0.037), Ruminococccaceae UBA 1819 0.010, 0.031) increased CP. Conclusion: alterations present RP. Taxonomic shifts reduced when Larger prospective are needed correlations clinical features translate these findings into future therapeutic approaches.

Language: Английский

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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(5), P. 2262 - 2274

Published: June 18, 2024

Abstract Cornus kousa fruit (CKF) has been utilized as anti‐obesity supplementation in East Asia, including Korea, and gut microbiota (GM) might have synergistic effects on obesity (OB) via its interplay. We aimed to decode molecule(s), mechanism(s), target(s) interplay between CKF GM network pharmacology analysis. The final targets were analyzed by protein–protein interaction (PPI) networks a bubble plot. interacted with significant identified the gutMGene database. relationships among or GM, signaling pathways, targets, molecules (CGSTM) plotted R package. Finally, molecular docking assay density functional theory (DFT) performed validate affinity. (22) selected OB‐responded indicating that interleukin‐6 (IL6) was most crucial protein‐coding target PPI networks. A plot CGSTM suggested advanced glycation end‐receptor for end products pathway diabetic complications is inhibited peroxisome proliferator–activated receptor (PPAR) activated GM. As stable conformers, IL6‐equol complex attributed PPAR alpha‐linoleic acid, delta‐stearic fatty acid–binding protein 4‐dimethyl 2,3‐bis(1,3‐dimethylindol‐2‐yl) fumarate CKF. Noticeably, stearic acid removed DFT analysis; all other three proposed good electron donators higher electronegativity compared standard drug (Orlistat). This study shows integrated pharmacological analysis can enable unknown Overall, this reveals combination of favorable exert dual therapeutic OB.

Language: Английский

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Biodiversity of intestinal Lactobacillus in relation to dietary habits and health status in Mongolians of China

Food Bioscience, Journal Year: 2023, Volume and Issue: 57, P. 103492 - 103492

Published: Dec. 23, 2023

Language: Английский

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