Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β DOI Creative Commons
Edyta Kawka, Rebecca Herzog, Marcin Ruciński

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 26, 2024

Abstract Transforming growth factor β (TGF-β) is implicated in both mesothelial-to-mesenchymal transition (MMT) and cellular senescence of human peritoneal mesothelial cells (HPMCs). We previously showed that senescent HPMCs could spontaneously acquire some phenotypic features MMT, which young were induced by TGF-β. Here, we used electron microscopy, as well global gene protein profiling to assess detail how exposure TGF-β impacts on vitro. found structural changes consistent with MMT young, but not HPMCs. Of all genes proteins identified reliably across treatments states, 4,656 targets represented overlapping proteins. Following TGF-β, 137 46 transcripts significantly changed cells, compared 225 only 2 cells. Identified differences between related predominantly wound healing, integrin-mediated signalling, production proteases extracellular matrix components, cytoskeleton structure. Thus, the response differs or less pronounced As a result, character magnitude postulated contribution TGF-β-induced remodelling may change cell senescence.

Language: Английский

The senescence-associated secretory phenotype and its physiological and pathological implications DOI
Boshi Wang, Jin Han, Jennifer H. Elisseeff

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(12), P. 958 - 978

Published: April 23, 2024

Language: Английский

Citations

153
Cellular senescence in cancer: molecular mechanisms and therapeutic targets DOI Creative Commons
Ping Jin,

Xirui Duan,

Lei Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(5)

Published: April 24, 2024

Abstract Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of senescence on tumor progression has received widespread attention. While how limits course cancer is well established, also been found to promote certain malignant phenotypes. The tumor‐promoting effect mainly elicited by a senescence‐associated secretory phenotype, which facilitates interaction senescent cells their surroundings. Targeting therefore offers promising technique for therapy. Drugs that pharmacologically restore normal function or eliminate them would assist reestablishing homeostasis cell signaling. Here, we describe its occurrence, impact biology. A “one‐two‐punch” therapeutic strategy first induced, followed use senotherapeutics eliminating introduced. advances application targeting treatment are outlined, an emphasis drug categories, strategies screening, design, efficient targeting. This work will foster thorough comprehension encourage additional within this field.

Language: Английский

Citations

14
Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection DOI Creative Commons
Zorica Janjetović, Andrzej Słomiński

Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 37 - 37

Published: March 1, 2024

Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin and its derivatives exert biological skin cells, thus maintaining homeostasis. In keratinocytes, they inhibit proliferation stimulate differentiation, have anti-inflammatory properties, act as antioxidants, DNA damage repair after ultraviolet (UV) exposure. melanocytes, also cell proliferation, apoptosis antioxidants. fibroblasts, affect fibrotic processes collagen production, promote wound healing regeneration. On the other hand, cells ability to activate directly. These activities, along with projected topical application derivatives, are promising for care photo protection can be used in prevention or possible reversal aging.

Language: Английский

Citations

11
Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects DOI Creative Commons
Han Li,

Dongsheng Wei,

Huimin Cao

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 301 - 323

Published: Jan. 1, 2025

Myocardial infarction (MI) is a prevalent cardiovascular disorder affecting individuals worldwide. There need to identify more effective therapeutic agents minimize cardiomyocyte damage and enhance cardioprotection. Bioinformatics analysis was performed predict the underlying biological mechanisms of ginkgetin in treatment MI. Next, we further validation through experiments. For vivo studies, used coronary ligation construct an MI rat model. In vitro, oxygen glucose deprivation (OGD) simulate ischemia H9c2 cardiomyocytes. revealed that key targets for were MMP2, MMP9, VEGFA. Immune infiltration might be involved immune regulation by acting on TCR signaling pathway. The results GO enrichment protect heart cell membrane alleviate senescent apoptosis cardiomyocytes after studies ameliorated myocardial pathological cardiac decompensation It also alleviated inflammatory Additionally, can downregulate activation signals pathway dephosphorylating CD3 CD28. vitro attenuated elevated OGD-induced cytotoxicity, increased viability, apoptosis, thus protecting Ginkgetin inhibits postinfarction fibrosis hypertrophy, scavenges free radicals, decreases limbic infiltration, suppresses inflammatory-immune pathway, delays peripheral cells from undergoing heart.

Language: Английский

Citations

1
Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches DOI Creative Commons
Ying Zeng, Francesco Buonfiglio, Jingyan Li

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Inflammaging refers to chronic, low-grade inflammation that becomes more common with age and plays a central role in the pathophysiology of various vascular diseases. Key inflammatory mediators involved inflammaging contribute endothelial dysfunction accelerate progression atherosclerosis. In addition, specific pathological mechanisms inflammasomes have emerged as critical drivers immune responses within vasculature. A comprehensive understanding these processes may lead innovative treatment strategies could significantly improve management age-related Emerging therapeutic approaches, including cytokine inhibitors, senolytics, specialized pro-resolving mediators, aim counteract restore health. This review seeks provide an in-depth exploration molecular pathways underlying highlight potential interventions.

Language: Английский

Citations

1
The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics DOI

Ashok Kumar Balaraman,

Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

1
Cardiovascular aging: spotlight on mitochondria DOI
Md Akkas Ali, Rachel A. Gioscia‐Ryan, Dongli Yang

et al.

AJP Heart and Circulatory Physiology, Journal Year: 2023, Volume and Issue: 326(2), P. H317 - H333

Published: Dec. 1, 2023

Mitochondria are cellular organelles critical for ATP production and particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion injury, cardiomyopathies. With advancing age, even in the absence of clinical disease, mitochondrial homeostasis becomes disrupted (e.g., redox balance, DNA damage, oxidative metabolism, quality control). Mitochondrial dysregulation leads accumulation damaged dysfunctional mitochondria, producing excessive reactive oxygen species perpetuating dysfunction. In addition, DNA, cardiolipin,

Language: Английский

Citations

14
Cardioprotective Response and Senescence in Aged sEH Null Female Mice Exposed to LPS DOI
Ala Yousef, Deanna K. Sosnowski, Liye Fang

et al.

AJP Heart and Circulatory Physiology, Journal Year: 2024, Volume and Issue: 326(6), P. H1366 - H1385

Published: April 5, 2024

Soluble epoxide hydrolase (sEH) is an essential enzyme for converting epoxy fatty acids to their less bioactive diols. Our study suggests deletion or inhibition of sEH impacts the aging process in hearts female mice resulting cardioprotection. Data indicate targeting limits inflammation, preserves mitochondria, and alters cellular senescence aged heart.

Language: Английский

Citations

4
SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence DOI Creative Commons
Alicia Villacampa, Licia Shamoon, Inés Valencia

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Premature vascular aging and endothelial cell senescence are major risk factors for cardiovascular diseases atherothrombotic disturbances, which main complications of both acute long COVID-19. The S protein SARS-CoV2, acts as the receptor binding viral infection, is able to induce cells inflammation it has been found an isolated element in circulation human tissues reservoirs months after infection. Here, we investigated whether directly deciphered some mechanisms involved. In primary cultures umbilical vein (HUVEC), SARS-CoV-2 enhanced a concentration-dependent manner cellular content DNA damage response markers (senescence-associated-β galactosidase, γH2AX), well growth-arrest effectors (p53, p21, p16). parallel, reduced availability cytoprotective proteins, such anti-aging klotho, Nrf2 or heme oxygenase-1, caused functional harm by impairing ex vivo endothelial-dependent vasorelaxation murine microvessels. These effects were prevented pharmacological inhibition NLRP3 inflammasome with MCC950. Furthermore, supplementation either recombinant klotho angiotensin-(1-7), equally protected against pro-senescence, pro-inflammatory pro-oxidant action protein. Globally, this study proposes novel disease context COVID-19 its sequelae provides clues order prevent complications.

Language: Английский

Citations

4
Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation DOI
X.J. Wang, Lei Huang, Min Hou

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

0