Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Jan. 6, 2024
Abstract
Background
Polycystic
ovary
syndrome
(PCOS)
is
an
exceedingly
intractable
issue
affecting
female
endocrine
and
reproductive
health.
However,
the
etiology
intricate
pathological
mechanisms
of
PCOS
remain
unclear.
Nowadays,
aging
was
found
to
share
multiple
common
with
PCOS,
which
causes
probing
into
pathogenesis
from
senescence.
no
bioinformatics
analyses
have
specifically
focused
on
connection
between
ovarian
aging.
Methods
Differentially
expressed
aging-related
genes
in
were
identified
then
analyzed
using
function
enrichment
method.
Hub
determined
based
algorithms,
expression
validation
hub
performed
both
datasets
experiments
(human
granulosa-like
tumor
cell
line,
KGN;
human
Granulosa
Cell,
hGCs).
Finally,
a
transcription
factor-miRNA-gene
network
constructed.
Results
Here,
we
73
differential
(ARDEGs)
by
intersecting
DEGs
senescence-related
gene
set.
Furthermore,
biological
functions
potential
pathways
ARDEGs
also
screened
algorithms.
From
perspective
immune
dysfunction,
correlation
cells.
TF-miRNA-gene
networks
Conclusions
Our
work
aimed
elucidate
relation
cellular
senescence
strategy,
deepening
understanding
seek
for
novel
therapy
strategies
improving
lifespan
Exploring
molecular
mechanism
expected
bring
new
breakthrough
diagnosis
strategies.
And
this,
might
deepen
our
about
American Journal of Physical Anthropology,
Journal Year:
2025,
Volume and Issue:
186(4)
Published: April 1, 2025
ABSTRACT
Objectives
Polycystic
ovary
syndrome
(PCOS)
is
a
multifaceted
heritable
endocrine
disorder
that
affects
4%–20%
of
females
worldwide.
Characterized
by
symptoms
such
as
polycystic
ovaries,
anovulation,
and
hyperandrogenism,
PCOS
remains
challenging
to
diagnose,
particularly
in
its
early
stages.
Research
suggests
women
with
may
experience
earlier
onset
menarche,
but
the
mechanisms
behind
this
association
are
not
well
understood.
This
study
explores
whether
menarche
could
serve
an
effective
diagnostic
marker
for
PCOS.
Materials
Methods
A
survey
was
conducted
95
adult
(ages
19–62),
divided
into
two
groups:
diagnosed
(49%,
n
=
47)
without
(51%,
48).
Participants
self‐identified
were
required
meet
Rotterdam
Criteria
diagnosis.
Notably,
all
participants
exhibited
hyperandrogenic
phenotype.
Independent
samples
t
‐tests
linear
regression
used
data
analysis.
Results
Women
reached
average
1.8
years
than
those
condition
(mean
age
11.4
±
1.6
vs.
13.2
1.2
years).
Discussion
These
findings
suggest
be
promising,
underexplored
indicator
PCOS,
offering
potential
new
avenue
diagnosis
condition.
valuable,
often
until
more
classic
symptoms,
anovulation
or
hirsutism,
emerge.
Further
research
needed
confirm
these
results
investigate
underlying
mechanisms.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 17, 2024
Polycystic
ovary
syndrome
(PCOS)
presents
a
significant
challenge
in
women's
reproductive
health,
characterized
by
disrupted
folliculogenesis
and
ovulatory
dysfunction.
Central
to
PCOS
pathogenesis
are
granulosa
cells,
whose
dysfunction
contributes
aberrant
steroid
hormone
production
oxidative
stress.
Mitochondrial
emerges
as
key
player,
influencing
cellular
energetics,
stress,
steroidogenesis.
This
study
investigates
the
therapeutic
potential
of
menstrual
blood-derived
stem
cells
(MenSCs)
their
exosomes
mitigating
mitochondrial
stress
cells.
Polycystic
ovary
syndrome
(PCOS)
is
increasingly
being
characterized
as
an
evolutionary
mismatch
disorder
that
presents
with
a
complex
mixture
of
metabolic
and
endocrine
symptoms.
The
Evolutionary
Model
proposes
PCOS
arises
from
collection
inherited
polymorphisms
have
been
consistently
demonstrated
in
variety
ethnic
groups
races.
In-utero
developmental
programming
susceptible
genomic
variants
are
thought
to
predispose
the
offspring
develop
PCOS.
Postnatal
exposure
lifestyle
environmental
risk
factors
results
epigenetic
activation
developmentally
programmed
genes
disturbance
hallmarks
health.
resulting
pathophysiological
changes
represent
consequences
poor-quality
diet,
sedentary
behaviour,
disrupting
chemicals,
stress,
circadian
disruption,
other
factors.
Emerging
evidence
suggests
lifestyle-induced
gastrointestinal
dysbiosis
plays
central
role
pathogenesis
Lifestyle
exposures
initiate
result
microbiome
(dysbiosis),
immune
dysregulation
(chronic
inflammation),
altered
metabolism
(insulin
resistance),
reproductive
imbalance
(hyperandrogenism),
nervous
system
dysfunction
(neuroendocrine,
autonomic
system).
can
be
progressive
condition
leads
obesity,
gestational
diabetes,
type
2
metabolic-associated
fatty
liver
disease,
syndrome,
cardiovascular
cancer.
This
review
explores
mechanisms
underpin
between
ancient
survival
pathways
contemporary
involved
pathophysiology
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Jan. 6, 2024
Abstract
Background
Polycystic
ovary
syndrome
(PCOS)
is
an
exceedingly
intractable
issue
affecting
female
endocrine
and
reproductive
health.
However,
the
etiology
intricate
pathological
mechanisms
of
PCOS
remain
unclear.
Nowadays,
aging
was
found
to
share
multiple
common
with
PCOS,
which
causes
probing
into
pathogenesis
from
senescence.
no
bioinformatics
analyses
have
specifically
focused
on
connection
between
ovarian
aging.
Methods
Differentially
expressed
aging-related
genes
in
were
identified
then
analyzed
using
function
enrichment
method.
Hub
determined
based
algorithms,
expression
validation
hub
performed
both
datasets
experiments
(human
granulosa-like
tumor
cell
line,
KGN;
human
Granulosa
Cell,
hGCs).
Finally,
a
transcription
factor-miRNA-gene
network
constructed.
Results
Here,
we
73
differential
(ARDEGs)
by
intersecting
DEGs
senescence-related
gene
set.
Furthermore,
biological
functions
potential
pathways
ARDEGs
also
screened
algorithms.
From
perspective
immune
dysfunction,
correlation
cells.
TF-miRNA-gene
networks
Conclusions
Our
work
aimed
elucidate
relation
cellular
senescence
strategy,
deepening
understanding
seek
for
novel
therapy
strategies
improving
lifespan
Exploring
molecular
mechanism
expected
bring
new
breakthrough
diagnosis
strategies.
And
this,
might
deepen
our
about
