Integrin Targeting and Beyond: Enhancing Cancer Treatment with Dual-Targeting RGD (Arginine–Glycine–Aspartate) Strategies DOI Creative Commons
B. Bogdanovič,

Daniel Fagret,

Cathérine Ghezzi

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1556 - 1556

Published: Nov. 20, 2024

Integrins, an important superfamily of cell adhesion receptors, play essential role in cancer progression, metastasis, and angiogenesis, establishing them as prime targets for both diagnostic therapeutic applications. Despite their significant potential, integrin-targeted therapies have faced substantial challenges clinical trials, including variable efficacy unmet high expectations. Nevertheless, the consistent expression integrins on tumor stromal cells underscores ongoing relevance potential. Traditional RGD-based imaging agents limitations, such inconsistent target rapid systemic clearance, which reduced effectiveness. To overcome these challenges, recent research has focused advancing strategies exploring innovative solutions. This review offers a thorough analysis latest developments RGD–integrin field, with particular focus addressing previous limitations. It delves into new dual-targeting approaches cutting-edge designed to improve diagnosis outcomes. By examining advancements, this illuminates pathways enhancing specificity therapies, paving way more effective treatment strategies.

Language: Английский

Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration DOI Creative Commons
Hossein Rayat Pisheh, Mahsa Sani

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 23, 2025

Language: Английский

Citations

3
Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology DOI Creative Commons
Karama Asleh,

Valerie Dery,

Cathy Taylor

et al.

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 17, 2023

Abstract While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing challenge. This can be largely attributed dynamic tumor-stroma interactions that continuously alter microenvironment. date most advancements have been made through examining clinical utility tissue-based biomarkers, their invasive nature lack holistic representation evolving disease in real-time manner could result suboptimal decisions. Thus, using minimally-invasive approaches identify biomarkers predict monitor response as well alert emergence recurrences critical need. Currently, research efforts shifting towards developing liquid biopsy-based obtained from patients over course disease. Liquid biopsy represents unique opportunity intercellular communication within tumor microenvironment which occur exchange extracellular vesicles (EVs). EVs lipid bilayer membrane nanoscale transfer plethora biomolecules mediate crosstalk, shape microenvironment, modify drug response. The capture innovative approaches, such microfluidics, magnetic beads, aptamers, allow analysis via high throughput multi-omics techniques facilitate use for biomarker discovery. Artificial intelligence, machine deep learning algorithms, advancing analyses uncover candidate predictive signatures key translation into trials. With increasing recognition role mediating immune evasion valuable source, these snapshots cellular promising become an important tool spur strategies block immunotherapy. In this review, we discuss emerging describing current advances isolation function mediators We also highlight recent lung melanoma studies point application potential immuno-oncology.

Language: Английский

Citations

33
Current research status of tumor cell biomarker detection DOI Creative Commons

Liying Jiang,

Xinyi Lin, Fenghua Chen

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Oct. 5, 2023

Abstract With the annual increases in morbidity and mortality rates of tumors, use biomarkers for early diagnosis real-time monitoring tumor cells is great importance. Biomarkers used cell detection body fluids include circulating cells, nucleic acids, protein markers, extracellular vesicles. Among them, DNA, exosomes have high potential prediction, diagnosis, prognosis diseases due to large amount valuable information on characteristics evolution; addition, situ telomerase miRNA living has been topic extensive research understand development real time. Various techniques, such as enzyme-linked immunosorbent assays, immunoblotting, mass spectrometry, widely these markers. markers based electrochemical biosensors fluorescence signal analysis highly preferred because its sensitivity, rapid portable operation. Herein, we summarize recent progress using biosensors, outline current status discuss technical challenges their practical clinical application provide a reference new marker methods.

Language: Английский

Citations

25
Exosomal noncoding RNA: A potential therapy for retinal vascular diseases DOI Creative Commons

Jong-Ik Heo,

Juhee Ryu

Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(1), P. 102128 - 102128

Published: Jan. 24, 2024

Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They secreted by cells play a regulatory role in various biological responses mediating cell-to-cell communication. Moreover, exosomes of interest developing therapies for retinal vascular disorders because they deliver substances to cellular targets. According recent research, be used as strategy managing diseases, being investigated therapeutic purposes eye conditions, including glaucoma, dry syndrome, ischemia, diabetic retinopathy, age-related macular degeneration. However, the exosomal noncoding RNA diseases is not fully understood. Here, we reviewed latest research on treating diseases. Research has shown RNAs, microRNAs, circular long RNAs significant regulation Furthermore, through exosome engineering, expression relevant controlled regulate Therefore, this review suggests could considered biomarker diagnosis target disease.

Language: Английский

Citations

12
A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications DOI
Xiying Fan, Yiwen Zhang, Wenshuai Liu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(14), P. 3500 - 3521

Published: Jan. 1, 2024

This review systematically summarizes the cutting-edge methods for preparing engineered exosomes through cell engineering and exosome engineering, as well latest advancements of in therapeutic applications.

Language: Английский

Citations

12
Deploying nucleic acids-loaded plant-derived exosomes as green nano gadget in cancer gene therapy DOI Creative Commons

Marola Paula Fawzy,

Hatem A. F. M. Hassan, Muhammad Umair Amin

et al.

Materials Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The pursuit of effective drug delivery systems is critical in advancing cancer therapies, particularly the realms chemotherapy, radiotherapy and immunotherapy.

Language: Английский

Citations

2
Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma DOI Creative Commons
Hong Yan, Nan Jiang, M Kellis

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 16, 2025

Multiple Myeloma (MM) is the second most common malignancy of hematopoietic system, accounting for approximately 10% all hematological malignancies, and currently, there no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in initiation progression tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, lncRNA-RNA binding proteins (RBP). Despite significant clinical application potential lncRNAs, this area still faces challenges due to their low abundance technical limitations. To our knowledge, review first comprehensively integrate elucidate three mechanisms action lncRNAs MM, propose therapeutic targets cases based on these mechanisms. We highlight latest advancements biomarkers targets, offering not only comprehensive analysis MM but also new perspectives methods future diagnosis treatment multiple myeloma.

Language: Английский

Citations

1
Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation DOI Creative Commons
Daniela Pinto,

Giammaria Giuliani,

Giorgia Mondadori

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 16 - 16

Published: Jan. 22, 2025

Exosomes, a subtype of extracellular vehicles (EVs), play pivotal role in cellular communication and have gained considerable attention dermatological research. Formed through the inward budding endosomal membrane, exosomes facilitate transfer proteins, lipids, nucleic acids, including microRNAs (miRNAs), thereby influencing behavior function recipient cells. These vesicles are secreted by various cell types, keratinocytes, crucial for maintaining skin homeostasis, regulating immune responses, promoting wound healing. Exosomes demonstrated therapeutic potential addressing conditions such as hair disorders, cancers photoaging enhanced regeneration reduced oxidative stress. However, they also implicated disease progression, with pathogens utilizing exosome release to evade host responses. Recent studies highlight diverse origins functions exosomes, suggesting their promise innovative agents dermatology. As research continues elucidate multifaceted roles, represent frontier understanding intercellular developing novel treatments skin-related diseases, underscoring impact on both health clinical applications. This review synthesizes existing literature biology isolation focus implications contexts.

Language: Английский

Citations

1
Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems DOI
Waleed Y. Rizg, Majed Alghamdi, Sherif El Saadany

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696

Published: Feb. 6, 2025

Language: Английский

Citations

1
Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy DOI Creative Commons
Zhangyi Luo, Chien‐Yu Chen, Song Li

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Recent advances in the development of tumor-targeting nanoparticles (NPs) significantly enhance cancer therapies by effectively increasing therapeutic window drugs, improving response tumor cells, and augmenting anti-tumor immunity. However, understanding process remains elusive because complex vivo behavior nanoparticles. Various factors are reported to alter this process; however, systematic studies on mechanisms remain limited. In review, an overview current strategies for targeting their applications chemotherapy immunotherapy, with a focus advancement various barriers effective penetration is provided.

Language: Английский

Citations

1