Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 243 - 263
Published: Nov. 3, 2023
Language: Английский
Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106732 - 106732
Published: March 15, 2023
High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in nucleus. Importantly, aberrant expression HMGA2 occurs during carcinogenesis, and this an upstream mediator cancer hallmarks including evasion apoptosis, proliferation, invasion, metastasis, therapy resistance. targets critical signaling pathways such as Wnt/β-catenin mTOR cells. Therefore, suppression function notably decreases progression improves outcome patients. As mainly oncogenic, targeting by non-coding RNAs (ncRNAs) crucial to take into consideration since it affects function. MicroRNAs (miRNAs) belong ncRNAs are master regulators vital cell processes, which affect all aspects hallmarks. Long (lncRNAs) circular (circRNAs), other members ncRNAs, mediators miRNAs. The current review intends discuss importance miRNA/HMGA2 axis modulation various types cancer, mentions lncRNAs circRNAs, regulate mediators. Finally, we effect miRNAs interactions on response cells therapy. Regarding role regulation cells, considering confirmed interaction between one miRNAs, promising could be subject future clinical trial experiments.
Language: Английский
Citations
24
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: April 25, 2024
Among women, breast cancer ranks as the most prevalent form of cancer, and presence metastases significantly reduces prognosis diminishes overall survival rates. Gaining insights into biological mechanisms governing conversion cells, their subsequent spread to other areas body, immune system’s monitoring tumor growth will contribute advancement more efficient targeted therapies. MicroRNAs (miRNAs) play a critical role in interaction between cells facilitating cells’ evasion system promoting progression. Additionally, miRNAs also influence metastasis formation, including establishment metastatic sites transformation migratory phenotypes. Specifically, dysregulated expression these genes has been associated with abnormal oncogenes suppressor genes, thereby development. This study aims provide concise overview significance function focusing on involvement suppressors antitumor response formation. Furthermore, hold tremendous potential targets for gene therapy due ability modulate specific pathways that can either promote or suppress carcinogenesis. perspective highlights latest strategies developed miRNA-based
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: May 15, 2024
Breast cancer (BC) is the second most common cause of deaths reported in women worldwide, and therefore there a need to identify BC patients at an early stage as timely diagnosis would help effective management appropriate monitoring patients. This will allow for proper patient care. However, absence particular biomarker surveillance makes it difficult accomplish these objectives. miRNAs have been identified master regulators molecular pathways that are emphasized various tumors lead advancement malignancies. Small, non-coding RNA molecules known target mRNAs control expression genes. dysregulation has linked start development number human malignancies, including BC, since compelling evidence can function tumor suppressor genes or oncogenes. The current level knowledge on role diagnosis, prognosis, treatment presented this review. regulate tumorigenesis through targeting PI3K pathway be used prognostic diagnostic biomarkers therapy. Some miRNAs, like miR-9, miR-10b, miR-17-5p, becoming therapeutic outcome prediction. Other miR-30c, miR-187, miR-339-5p, play significant roles regulation hallmark functions invasion, metastasis, proliferation, resting death, apoptosis, genomic instability. such miR-155 miR-210, circulating bodily fluids interest novel, conveniently accessible, reasonably priced, non-invasive methods customized care with BC.
Language: Английский
Citations
8
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Aug. 23, 2024
Chalcogens are used as sensitive redox-responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site-directed and real-time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S-S, approximately 240 kJ/mol), diselenium (Se-Se, 172 tellurium (Te-Te, 126 kJ/mol)), including ditelluride-bond-bridged MONs (DTeMSNs), diselenide-bond-bridged (DSeMSNs) disulfide-bond-bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X-rays, resulting TeO
Language: Английский
Citations
7
GeroScience, Journal Year: 2024, Volume and Issue: 46(6), P. 6641 - 6657
Published: July 2, 2024
Abstract Canine mammary tumors (CMTs) represent a significant health concern in dogs, with high incidence among intact female dogs. CMTs are promising comparative model for human breast cancer, due to sharing several pathophysiological features. Additionally, have strong genetic correlation their counterpart, including the expression of microRNAs (miRNAs). MiRNAs class non-coding RNAs that play important roles post-translational regulation gene expression, being implicated carcinogenesis, tumor progression, and metastasis. Moreover, miRNAs hold promise as diagnostic, prognostic, metastatic biomarkers. Understanding molecular mechanisms underlying is crucial improving diagnosis, prognosis, monitoring treatments. Herein, we provide comprehensive overview current knowledge on CMTs, highlighting carcinogenesis potential highlight limitations critically discuss overarching challenges this field, emphasizing need future research translate miRNA findings into veterinary clinical practice.
Language: Английский
Citations
6
Bioelectrochemistry, Journal Year: 2024, Volume and Issue: 160, P. 108771 - 108771
Published: July 4, 2024
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9984 - 9984
Published: June 10, 2023
Breast cancer (BC) is a leading cause of cancer-related deaths among women worldwide. Neoadjuvant therapy (NAT) increasingly being used to reduce tumor burden prior surgical resection. However, current techniques for assessing response have significant limitations. Additionally, drug resistance commonly observed, raising need identify biomarkers that can predict treatment sensitivity and survival outcomes. Circulating microRNAs (miRNAs) are small non-coding RNAs regulate gene expression been shown play role in progression as inducers or suppressors. The circulating miRNAs has found be significantly altered breast patients. Moreover, recent studies suggested serve non-invasive predicting NAT. Therefore, this review provides brief overview demonstrated the potential clinical NAT BC findings will strengthen future research on developing miRNA-based their translation into medical practice, which could improve management patients undergoing
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 956 - 956
Published: Jan. 12, 2024
The number of children suffering from cardiovascular diseases (CVDs) is rising globally. Therefore, there an urgent need to acquire a better understanding the genetic factors and molecular mechanisms related pathogenesis CVDs in order develop new prevention treatment strategies for future. MicroRNAs (miRNAs) constitute class small non-coding RNA fragments that range 17 25 nucleotides length play essential role regulating gene expression, controlling abundance biological aspects cell life, such as proliferation, differentiation, apoptosis, thus affecting immune response, stem growth, ageing haematopoiesis. In recent years, concept miRNAs diagnostic markers allowing discrimination between healthy individuals those affected by entered purview academic debate. this review, we aimed systematise available information regarding associated with arrhythmias, cardiomyopathies, myocarditis congenital heart children. We focused on targeted genes metabolic pathways influenced particular miRNAs, finally, tried determine future novel biomarkers CVD.
Language: Английский
Citations
4
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: May 15, 2024
Introduction: Breast cancer represents the most prevalent malignancy among women. Recent advancements in translational research have focused on identification of novel biomarkers capable providing valuable insights into patient outcomes. Furthermore, comprehensive investigations aimed at discovering miRNAs, unraveling their biological functions, and deciphering target genes significantly contributed to our understanding roles miRNAs play tumorigenesis. Consequently, these facilitated way for development miRNA-based approaches breast prognosis, diagnosis, treatment. However, conducting a more extensive array studies, particularly diverse ethnic groups, is imperative expand scope validate significance miRNAs. This study assess expression patterns circulating plasma as prospective biomarker patients within population primarily consisting individuals from Black, Indigenous, People Color (BIPOC) communities. Methods: We evaluated 49 with compared 44 healthy Results discussion: All analyzed were downregulated. ROC curve analysis miR-21 (AUC = 0.798, 95% CI: 0.682–0.914, p <0.0001), miR-1 0.742, 0.576–0.909, 0.004), miR-16 0.721, 0.581–0.861, 0.002) miR-195 0.672, 0.553–0.792, 0.004) showed better diagnostic accuracy discrimination comparison miR-210, highest specificities values (97.3%, 94.1%, respectively). Following, miR-10b sensitivity (89.3%, 77.8%, The panel combination four (miR-195 + miR-210 miR-16) had an AUC 0.898 (0.765–0.970), 71.4%, specificity 100.0%. Collectively, results highlight miRNA panels drastically improves high diagnosis displaying good specificity.
Language: Английский
Citations
4
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)
Published: Aug. 23, 2024
Abstract Chalcogens are used as sensitive redox‐responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site‐directed and real‐time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S−S, approximately 240 kJ/mol), diselenium (Se−Se, 172 tellurium (Te−Te, 126 kJ/mol)), including ditelluride‐bond‐bridged MONs (DTeMSNs), diselenide‐bond‐bridged (DSeMSNs) disulfide‐bond‐bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X‐rays, resulting TeO 3 2− . Furthermore, chalcogen‐hybridized was loaded manganese ions (Mn 2+ ) enhance release of Mn during radiotherapy, thereby activating stimulator interferon genes (STING) pathway enhancing immune response inhibit growth. investigation deepens our understanding chalcogens characteristics radiotherapy enriches design principles for nanomedicine prodrugs.
Language: Английский
Citations
4