Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 407 - 467
Published: Jan. 1, 2023
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115864 - 115864
Published: Nov. 9, 2023
Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and enhanced fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, glycolipid metabolism. ATF4 induces the differentiation of marrow mesenchymal stem cells (BM-MSCs) into osteoblasts, increases osteoblast activity, inhibits osteoclast formation, promoting formation remodeling. In addition, mediates energy metabolism osteoblasts promotes angiogenesis. also involved mediation adipogenesis. can selectively accumulate osteoblasts. directly interact with RUNT-related 2 (RUNX2) up-regulate expression osteocalcin (OCN) osterix (Osx). Several upstream factors, such as Wnt/β-catenin BMP2/Smad signaling pathways, have been ATF4-mediated differentiation. osteoclastogenesis mediating receptor activator nuclear κ-B (NF-κB) ligand (RANKL) signaling. agents, parathyroid (PTH), melatonin, natural compounds, reported to regulate mediate this review, we comprehensively discuss biological activities maintaining homeostasis inhibiting OP development. has become therapeutic target for treatment.
Language: Английский
Citations
23
Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122549 - 122549
Published: March 22, 2024
The availability of human cell-based models capturing molecular processes cartilage degeneration can facilitate development disease-modifying therapies for osteoarthritis (Acevedo Rua et al., 2021) [1], a currently unmet clinical need. Here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at defined stage chondrogenesis, we engineered organotypic model which recapitulates main OA pathological traits such as chondrocyte hypertrophy, matrix mineralization, enhanced catabolism and mechanical stiffening. To exemplify the utility model, exposed organoids to factors known attenuate features, including IL-1Ra, carried out mass spectrometry-based proteomics. We identified that IL-1Ra strongly reduced production transcription factor CCAAT/enhancer-binding protein beta (Hirata 2012) [2] demonstrated inhibition C/EBPβ-activating kinases could revert degradative processes. Human thus represent relevant tool towards discovery new drivers assessment therapeutics targeting associated pathways.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 22, 2025
Cell penetrating peptides (CPPs) are usually positive charged and have good cell membrane permeability. Meanwhile, CPPs facile to synthesize, can be functionalized satisfy different demands, such as cyclization, incorporating unnatural amino acids, lipid conjugation. These properties made them efficient drug-delivery tools deliver therapeutic molecules cells tissues in a nontoxic manner, including small molecules, DNA, siRNA, proteins other various nanoparticles. However, the poor serum stability low tumor targeting ability also hindered their broad application. Besides, inappropriate chemical modification lead disruption nonspecific toxicity. In this paper, we first reviewed recent advances CPP applications for cancer therapy via covalent or non-covalent manners. We carefully analyzed advantages disadvantages of each modifications drug delivery. Then, concluded progress clinical trials diseases. Finally, discussed challenges opportunities met translate into applications. This review presented new insight delivery, which could provide advice on design clinically effective systemic delivery systems using CPPs.
Language: Английский
Citations
0
Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)
Published: Feb. 13, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 666 - 666
Published: Feb. 16, 2025
The human pituitary is a gland located within small bony box, the sella turcica, under base of brain [...]
Language: Английский
Citations
0
EJC Paediatric Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 100223 - 100223
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 14, 2025
Abstract CCAAT/enhancer-binding protein delta (CEBPD), as an evolutionarily conserved in mammals, belongs to the CEBP transcription factor family, which modulates many biological processes. The diversity of CEBPD functions partly depends on cell type and cellular context. Aberrant expression activity are associated with multiple organ diseases, including cardiovascular diseases. In this review, we describe basic molecular biology understand its regulation, modifications, functions. Here, summarize recent advances genetically modified animals CEBPD. Finally, discuss contribution diseases highlight strategies for developing novel therapies targeting
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 21, 2025
Transmembrane protein 71 (TMEM71) is implicated in multiple cellular physiological functions and has been demonstrated to be crucial the advancement of different cancerous growths. However, its specific function low-grade glioma (LGG) remains unclear. We examined expression patterns prognostic importance TMEM71 various types cancer by using pan-cancer analysis. The analyses correlations between clinicopathological characteristics, prognosis, biological functions, immune genomic variations LGG were conducted based on patterns. Finally, level verified executing vitro studies. Abnormal elevation was associated with poor prognosis many tumors including LGG. Both multivariate univariate Cox regression indicated that served as a standalone biomarker for levels immune-related infiltration cells, checkpoint genes (ICPGs) expression, tumor mutation burden (TMB) patients In laboratory studies, elevated found involved activating JAK2/STAT3 pathway, promoting CCAAT/Enhancer Binding Protein D (CEBPD) ultimately affecting growth motility cells. an independent indicator strongly positioning it potential novel target treatment.
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217716 - 217716
Published: April 1, 2025
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217731 - 217731
Published: April 1, 2025
Language: Английский
Citations
0