Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Nov. 5, 2024
Long
non‑coding
RNAs
serve
a
crucial
role
in
autophagy
of
vascular
smooth
muscle
cells
(VSMCs).
The
present
study
aimed
to
investigate
the
effect
small
nucleolar
RNA
host
gene
1
(SNHG1)
on
VSMCs
and
associated
underlying
mechanisms.
Rapamycin
was
used
induce
effects
SNHG1
proliferation
migration
change
phenotype
were
tested
following
overexpression
silencing
SNHG1.
target
predicted
validated.
SNHG1‑regulated
via
C‑type
lectin
domain
family
7
member
A
(CLEC7A)
determined
by
combined
CLEC7A.
Rapamycin‑induced
changed
cell
from
contractile
synthetic,
with
decreased
expression
α‑smooth
actin
protein
22a
increased
osteopontin.
Overexpression
caused
same
while
opposite
observed
silencing.
promoted
VSMCs.
CLEC7A
identified
as
direct
binding
relationship
between
them
confirmed
immunoprecipitation
pull‑down
assays.
both
during
reduced
this
In
conclusion,
autophagy.
promotes
conversion
synthetic
facilitating
expression.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(12), P. 3063 - 3078
Published: Jan. 1, 2024
A
drug
delivery
system
(NPS
BG
@Cur)
has
been
developed
to
respond
ROS
and
deliver
the
autophagy
activator
curcumin
(Cur)
reduce
severity
of
AKI.
This
works
by
activating
promoting
degradation
lipid
droplets.
Poultry Science,
Journal Year:
2025,
Volume and Issue:
104(4), P. 104923 - 104923
Published: Feb. 17, 2025
Avian
leukosis
virus
subgroup
J
(ALV-J)
is
an
immunosuppressive
neoplastic
virus,
the
growth
retardation
and
performance
of
chickens
after
infection.
Circular
RNAs
(circRNAs)
play
a
crucial
role
in
various
types
cancer.
In
previous
study,
we
showed
that
circ-Vav3
was
significantly
elevated
tumor
livers
avian
leukosis-infected
chickens.
Autophagy
essential
cellular
process,
circRNAs
have
been
confirmed
to
be
key
players
autophagy
regulation.
this
demonstrated
overexpression
inhibited
autophagy.
Specifically,
functions
as
sponge
for
gga-miR-375,
resulting
increased
expression
CIP2A,
which
target
gene
gga-miR-375.
turn,
hinders
fusion
autophagosomes
with
lysosomes,
leading
incomplete
autophagic
flux,
consequently,
inhibition
Further
study
gga-miR-375
inhibits
CIP2A
promotes
by
downregulating
p-AKT.
Additionally,
treated
cells
rapamycin
induce
then
cotransfected
them
The
results
cotransfection
Moreover,
exhibited
further
ALV-J
infection,
suggesting
involved
inhibiting
caused
infection
through
regulation
gga-miR-375/CIP2A/AKT.
conclusion,
our
gga-miR-375/CIP2A/AKT
pathway
mediated
suppression
ALV-J-induced
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 339 - 339
Published: March 13, 2025
Plant-based
stilbenes
are
low-molecular-weight
polyphenolic
compounds
that
exhibit
anti-oxidant,
anti-microbial,
anti-fungal,
anti-inflammatory,
anti-diabetic,
cardioprotective,
neuroprotective,
and
anti-cancer
activities.
They
phytoalexins
produced
in
diverse
plant
species
response
to
stress,
such
as
fungal
bacterial
infections
or
excessive
UV
irradiation.
Plant-derived
dietary
products
containing
common
components
of
the
human
diet.
Stilbenes
appear
be
promising
chemopreventive
chemotherapeutic
agents.
Accumulating
evidence
indicates
able
trigger
both
apoptotic
autophagic
molecular
pathways
many
cancer
cell
lines.
Of
note,
crosstalk
between
autophagy
apoptosis
under
cellular
stress
conditions
determines
fate.
The
relationship
is
complex
depends
on
context,
e.g.,
type
level.
Apoptosis
a
regulated
death,
whereas
may
act
pro-survival
pro-death
mechanism
depending
context.
interplay
have
an
important
impact
chemotherapy
efficiency.
This
review
focuses
vitro
effects
different
lines
concerning
apoptosis.
PLANT PHYSIOLOGY,
Journal Year:
2025,
Volume and Issue:
197(3)
Published: March 1, 2025
Abstract
Transport
protein
particle
(TRAPP)
tethering
complexes
are
known
for
their
function
as
Rab
GTPase
exchange
factors.
Two
versions
of
the
complex
considered
functionally
separate:
TRAPPII,
an
activator
Rab11
family
(RabA
in
plants)
GTPases
that
post-Golgi
sorting,
and
TRAPPIII,
activating
Rab1
(RabD
members
regulate
endoplasmic
reticulum
(ER)-to-Golgi
trafficking
autophagy.
In
Arabidopsis
(Arabidopsis
thaliana),
TRAPPIII
has
been
identified
its
subunit
composition
established,
but
little
is
about
functions.
Here,
we
found
binary
interactions
plant
analogous
to
those
metazoan
with
2
large
subunits
TRAPPC8
TRAPPC11
linking
TRAPP
core
small
C12
C13
dimer.
To
gain
insight
into
functions
plants,
characterized
A.
thaliana
trappc8
mutants.
These
mutants
display
abnormalities
morphology,
particularly
flower
seed
development.
They
also
exhibit
autophagic
defects,
a
constitutive
ER
stress
response,
elevated
levels
lipid
dolichol
(Dol),
which
indispensable
cofactor
glycosylation.
results
indicate
involved
multiple
cellular
events
suggest
link
between
responses
Dol
levels.
