Physiological Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 189 - 203
Published: April 30, 2024
This
comprehensive
review
explores
the
physiological
and
pathophysiological
significance
of
VPS13A,
a
protein
encoded
by
VPS13A
gene.
The
gene
is
associated
with
Chorea-acanthocytosis
(ChAc),
rare
hereditary
neurodegenerative
disorder.
covers
essential
aspects,
beginning
genetics
highlighting
its
role
in
pathogenesis
ChAc,
addressing
spectrum
genetic
variants
involved.
It
delves
into
structure
function
protein,
emphasizing
presence
various
tissues
potential
involvement
trafficking
lipid
homeostasis.
Molecular
functions
brain
tissue
other
cell
types
or
respect
to
their
cytoskeletal
regulation
autophagy
are
explored.
Finally,
it
intriguing
link
between
mutations,
imbalances,
neurodegeneration,
shedding
light
on
future
research
directions.
Overall,
this
serves
as
resource
for
understanding
pivotal
health
disease,
particularly
context
ChAc.
Key
words:
Chorein
,
Tumor,
Actin,
Microfilament,
Gene
expression,
Chorea-acanthocytosis.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(12), P. 3063 - 3078
Published: Jan. 1, 2024
A
drug
delivery
system
(NPS
BG
@Cur)
has
been
developed
to
respond
ROS
and
deliver
the
autophagy
activator
curcumin
(Cur)
reduce
severity
of
AKI.
This
works
by
activating
promoting
degradation
lipid
droplets.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(26), P. 14727 - 14746
Published: June 22, 2024
:
Following
spinal
cord
injury
(SCI),
autophagy
plays
a
positive
role
in
neuronal
protection,
whereas
pyroptosis
triggers
an
inflammatory
response.
Ginsenoside-Rh2
(GRh2),
known
for
its
neuroprotective
effects,
is
considered
promising
drug.
However,
the
exact
molecular
mechanisms
underlying
these
protective
effects
remain
unclear.
Molecular Biology of the Cell,
Journal Year:
2024,
Volume and Issue:
35(10)
Published: Aug. 7, 2024
Subversion
of
cellular
membranes
and
membrane
proliferation
are
used
by
positive-strand
RNA
viruses
to
build
viral
replication
organelles
(VROs)
that
support
virus
replication.
The
biogenesis
the
membranous
VROs
requires
major
changes
in
lipid
metabolism
transfer
infected
cells.
In
this
work,
we
show
tomato
bushy
stunt
(TBSV)
hijacks
Atg2
autophagy
related
protein
with
bulk
activity
into
via
interaction
TBSV
p33
protein.
Deletion
yeast
knockdown
Poultry Science,
Journal Year:
2025,
Volume and Issue:
104(4), P. 104923 - 104923
Published: Feb. 17, 2025
Avian
leukosis
virus
subgroup
J
(ALV-J)
is
an
immunosuppressive
neoplastic
virus,
the
growth
retardation
and
performance
of
chickens
after
infection.
Circular
RNAs
(circRNAs)
play
a
crucial
role
in
various
types
cancer.
In
previous
study,
we
showed
that
circ-Vav3
was
significantly
elevated
tumor
livers
avian
leukosis-infected
chickens.
Autophagy
essential
cellular
process,
circRNAs
have
been
confirmed
to
be
key
players
autophagy
regulation.
this
demonstrated
overexpression
inhibited
autophagy.
Specifically,
functions
as
sponge
for
gga-miR-375,
resulting
increased
expression
CIP2A,
which
target
gene
gga-miR-375.
turn,
hinders
fusion
autophagosomes
with
lysosomes,
leading
incomplete
autophagic
flux,
consequently,
inhibition
Further
study
gga-miR-375
inhibits
CIP2A
promotes
by
downregulating
p-AKT.
Additionally,
treated
cells
rapamycin
induce
then
cotransfected
them
The
results
cotransfection
Moreover,
exhibited
further
ALV-J
infection,
suggesting
involved
inhibiting
caused
infection
through
regulation
gga-miR-375/CIP2A/AKT.
conclusion,
our
gga-miR-375/CIP2A/AKT
pathway
mediated
suppression
ALV-J-induced
