The “conflict avoidance theory of inflammation-induced anxiety” (CATIA): A psychoneuroimmunologic hypothesis

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111580 - 111580

Published: Jan. 1, 2025

Language: Английский

---

A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants

Science Translational Medicine, Journal Year: 2025, Volume and Issue: 17(788)

Published: March 5, 2025

Extremely premature infants (EPIs) who are born before 30 weeks of gestation susceptible to infection; however, the trajectory their peripheral immunity is poorly understood. Here, we undertook longitudinal analyses immune cells from 250 μl whole blood at 1 week, month, and 2 months 10 EPIs compared these with samples healthy adults preterm full-term cord samples. Single-cell suspensions individual were split perform single-cell RNA sequencing, T B cell receptor phosphoprotein mass cytometry. The trajectories circulating T, B, myeloid, natural killer in over first life distinct those infants. In EPIs, development rapidly progressed month life, an increase proportion naïve CD4+, regulatory, cycling cells, accompanied by greater STAT5 (signal transducer activator transcription 5) signaling. EPI memory CD4+ showed a helper (TH1) predominance TH2 skewing central memory-like infants, 2-month-old exhibited increased signatures activation differentiation. Both displayed interferon conclusion, demonstrated feasibility multiomic using minute amounts developed resource describing that suggested ongoing early life.

Language: Английский

---

Decoding the mitochondrial connection: development and validation of biomarkers for classifying and treating systemic lupus erythematosus through bioinformatics and machine learning

BMC Rheumatology, Journal Year: 2023, Volume and Issue: 7(1)

Published: Dec. 4, 2023

Abstract Background Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by clinical and pathological diversity. Mitochondrial dysfunction has been identified as critical pathogenetic factor in SLE. However, the specific molecular aspects regulatory roles of this SLE are not fully understood. Our study aims to explore characteristics mitochondria-related genes (MRGs) SLE, with focus on identifying reliable biomarkers for classification therapeutic purposes. Methods We sourced six SLE-related microarray datasets (GSE61635, GSE50772, GSE30153, GSE99967, GSE81622, GSE49454) from Gene Expression Omnibus (GEO) database. Three these GSE30153) were integrated into training set differential analysis. The intersection differentially expressed MRGs yielded (DE-MRGs). employed machine learning algorithms—random forest (RF), support vector (SVM), least absolute shrinkage selection operator (LASSO) logistic regression—to select key hub genes. These genes’ classifying potential was validated three other validation sets (GSE99967, GSE49454). Further analyses included expression, co-expression, protein-protein interaction (PPI), gene enrichment analysis (GSEA), immune infiltration, centered also constructed TF-mRNA, miRNA-mRNA, drug-target networks based using ChEA3, miRcode, PubChem databases. Results investigation 761 (DEGs), mainly related viral infection, inflammatory, immune-related signaling pathways. between DEGs led identification 27 distinct DE-MRGs. Key among FAM210B, MSRB2, LYRM7, IFI27, SCO2, designated through Their significant role confirmed both sets. Additional PPI, GSEA, construction networks. Conclusions This research represents novel exploration SCO2 candidates targeting.

Language: Английский

---

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 3, 2024

Abstract The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility disorders after birth. Because it not well understood how the placenta fetus respond acute lung- inflammation, we characterize response pulmonary lipopolysaccharide exposure across 24 h in using multi-omics, imaging integrative analyses. Unlike organs, mount strong inflammatory immune responses, upregulates immuno-modulatory genes, particular IL-6 signaling suppressor Socs3 . Similarly, observe no liver, instead displays metabolic changes, including increases lipids containing docosahexaenoic acid, crucial for brain development. liver plasma display similar alterations, potentially increasing bioavailability acid mother fetus. Thus, our integrated temporal analysis shows that systemic leads a

Language: Английский

---

Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Maternal Inflammatory Proteins in Pregnancy and Neurodevelopmental Disorders at Age 10 Years

JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

IMPORTANCE Maternal inflammation during pregnancy has been associated with an increased risk of neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD) and autism, cognitive deficits in early childhood. However, little is known about the contributions a wider range inflammatory proteins to this risk. OBJECTIVE To determine whether maternal are NDDs executive functions (EF) middle childhood identify protein patterns EF. DESIGN, SETTING, AND PARTICIPANTS This was 10-year follow-up cohort study Danish Copenhagen Prospective Studies on Asthma 2010 mother-child birth cohort, using plasma samples collected at week 24 pregnancy, where 92 were assessed. EF assessed offspring age 10 years, between January 2019 December 2021. Mother-offspring dyads available prenatal NDD psychopathology data included. Data analyses took place 2023 August 2024. EXPOSURES Levels from panel pregnancy. MAIN OUTCOMES MEASURES Categorical dimensional (primary outcome) (secondary outcome). RESULTS A total 555 mothers (mean [SD] age, 32.4 [4.3] years) their children (285 male [51%]) The principal component analysis showed that higher levels depicted 1 any (OR, 1.49; 95% CI, 1.15-1.94; P = .003), particularly autism 2.76; 1.45-5.63; .003) ADHD predominantly inattentive presentation 1.57; 1.05-2.39; .03). single 18 reached false discovery rate (FDR) 5% significance after adjustment. Vascular endothelial growth factor A, C-C motif chemokine ligand, CD5, interleukin 12B, fibroblast factor-23, monocyte chemoattractant protein-1 emerged top NDDs. sparse partial least squares approach identified 34 NDD, 39 presentation. There no associations FDR correction. CONCLUSIONS RELEVANCE proteome risks years. Further research warranted elucidate specific pathways involving these could be targeted prevention strategies reduce children.

Language: Английский

---

Ontogenetic Neuroimmune Changes Following Prenatal Alcohol Exposure: Implications for Neurobehavioral Function

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 15 - 39

Published: Jan. 1, 2025

Language: Английский

---

Maternal Immune Activation: Implications for Congenital Heart Defects

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 2, 2025

Language: Английский

---

Maternal Immune Activation and Child Brain Development: A Longitudinal Population-based Multimodal Neuroimaging study

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 10(2), P. 222 - 235

Published: Nov. 2, 2024

Language: Английский

---

Subsequent maternal sleep deprivation aggravates neurobehavioral abnormalities, inflammation, and synaptic function in adult male mice exposed to prenatal inflammation

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 25, 2023

Studies have suggested that prenatal exposure to inflammation increases the risk of neuropsychiatric disorders, including anxiety, depression, and cognitive dysfunction. Because anatomical hormonal alterations, pregnant women frequently experience sleep dysfunction, which can enhance inflammatory response. The aim this study was explore effects maternal deprivation on exposure-induced behavioral phenotypes in offspring identify associated mechanisms.Pregnant mice received an intraperitoneal injection lipopolysaccharide (LPS) gestational day 15 were subsequently subjected during days 15-21. Anxiety-like behavior evaluated by open field test elevated plus maze test. Depression-like assessed tail suspension forced swimming Cognitive function determined using Morris water levels markers synaptic examined employing general molecular biological techniques.The results showed LPS resulted anxiety- depression-like symptoms learning memory deficits, these exacerbated deprivation. Furthermore, aggravated increase expression interleukin (IL)-1β, IL-6, tumor necrosis factor-α decrease postsynaptic density-95 synaptophysin hippocampus.Collectively, exacerbates impairment induced exposure, with response

Language: Английский

---