The possible effects of common air pollutants on the pathophysiology of functional gastrointestinal disorders: A narrative review DOI Creative Commons

Mahshad Heidarian Boroujeni,

Bahare Dehdashti, Mohammad Mehdi Amin

et al.

International Journal of Environmental Health Engineering, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 21, 2023

Abstract There are more than seven million premature deaths every year linked to air pollution effects. The critical hazards of exposure the increased risk respiratory and cardiovascular diseases, which can boost morbidity mortality. Besides, ingested pollutants cause gastrointestinal (GI) diseases. Functional GI disorders (FGIDs) called gut-brain interaction that influence approximately one out four people have negative effects on life quality, work productivity, medical costs. Intestinal inflammation, gut microbiota, motility three important factors in pathogenesis pathways these disorders. This literature aimed clarify link between pathophysiology FGIDs. study was conducted based published studies English using scientific databases, such as PubMed, Embase, Web Science, Google Scholar, from 1990 2023. We used various combinations relevant keywords, pollution, pollutant, FGID, inflammation. findings indicated contribute etiology FGIDs through dysbiosis intestinal In addition, may alter composition diversity turn play major roles development addition steps taken by government tackle there some recommendations prevent exposure, consumption biotics a diet.

Language: Английский

Pollutants, microbiota and immune system: frenemies within the gut DOI Creative Commons
Pierluigi Rio, Antonio Gasbarrini,

Giovanni Gambassi

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 10, 2024

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.

Language: Английский

Citations

8
Gut–lung axis: role of the gut microbiota in non-small cell lung cancer immunotherapy DOI Creative Commons
Huaiyuan Zhang, Ziyuan Xu

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Nov. 22, 2023

Immunotherapy for non-small cell lung cancer (NSCLC) has advanced considerably over the past two decades. In particular, immune checkpoint inhibitors are widely used treating NSCLC. However, overall cure and survival rates of patients with NSCLC remain low. Therefore, continuous investigation into complementary treatments is necessary to expand clinical advantages immunotherapy a larger cohort Recently, distinctive role gut microbiota (GM) in initiation, progression, dissemination attracted increasing attention. Emerging evidence indicates close relationship between lungs, known as gut–lung axis (GLA). this review, we aim provide comprehensive summary current knowledge regarding connection GM outcomes NSCLC, particular focus on recent understanding GLA. Overall, promising GM-based therapeutic strategies have been observed improve effectiveness or reduce toxicity thus advancing utilization precision medicine.

Language: Английский

Citations

11
Therapeutic potential of short-chain fatty acids for acute lung injury: a systematic review and meta-analysis of preclinical animal studies DOI Creative Commons

Liying Xie,

Linyan Wang, Yaling Liao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 8, 2025

Short-chain fatty acids (SCFAs), derived from the fermentation of dietary fiber by intestinal commensal bacteria, have demonstrated protective effects against acute lung injury (ALI) in animal models. However, findings shown variability across different studies. It is necessary to conduct a comprehensive evaluation efficacy these treatments and their consistency. This systematic review meta-analysis aimed explore SCFAs on ALI based preclinical research evidence, order provide new treatment strategies for ALI. We included studies that tested study was performed according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A search relevant conducted PubMed, Embase, Web Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) databases up February 2024. The data were extracted accordance with established selection criteria, risk bias evaluated each study. total 16 articles finally meta-analysis. results indicated significantly reduced wet-to-dry weight (SMD = -2.75, 95% CI -3.46 -2.03, p < 0.00001), scores -5.07, -6.25 -3.89, myeloperoxidase -3.37, -4.05 -2.70, tumor necrosis factor-alpha -3.31, -4.45 -2.16, 0.00001) malondialdehyde -3.91, -5.37 -2.44, levels models subgroup analysis varies dosage duration treatment. can reduce inflammation oxidative stress clinical deserves further in-depth research. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=584008, CRD42024584008.

Language: Английский

Citations

0
Lactobacillus acidophilus TW01 Mitigates PM2.5-Induced Lung Injury and Improves Gut Health in Mice DOI Open Access
Siou-Min Luo, Ming‐Ju Chen

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 831 - 831

Published: Feb. 27, 2025

Background/Objectives: Exposure to fine particulate matter (PM2.5) causes significant respiratory and gastrointestinal health problems. In our prior research, we identified Lactobacillus acidophilus TW01 as a promising strain for mitigating oxidative damage, enhancing wound healing in intestinal epithelial cells, protecting bronchial cells from cigarette smoke extract. Building upon these findings, this study examines the protective effects of on lung damage induced by (PM) through gut-lung axis mouse models. Methods: This evaluated L. against PM2.5-induced injury using two vivo models (OVA sensitization combined with PM2.5 exposure DSS-induced colitis). Results: exhibited in-vivo models, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-5), modulating immune response (IgG subtypes), improving gut barrier integrity. Importantly, increased abundance beneficial bacteria (Bifidobacterium Lactobacillus). Conclusions: These findings highlight protective/therapeutic potential adverse exposure, emphasizing interplay between microbiomes overall health. The multi-faceted probiotic suggest novel, multi-pronged therapeutic strategy addressing widespread consequences air pollution.

Language: Английский

Citations

0
Polycyclic aromatic hydrocarbon-aryl hydrocarbon receptor signaling regulates chronic inflammation in lung-gut axis DOI
Tzu-Yu Cheng,

Ching-Shan Luo,

Po‐Hao Feng

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117359 - 117359

Published: May 1, 2025

Language: Английский

Citations

0
Exploring the Role of Gut-Lung Interactions in COPD Pathogenesis: A Comprehensive Review on Microbiota Characteristics and Inflammation Modulation DOI Open Access
Zi-Xuan Cheng, Jing Zhang

Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation, Journal Year: 2024, Volume and Issue: 11(3), P. 311 - 325

Published: Jan. 1, 2024

Chronic obstructive pulmonary disease (COPD) is a paramount contributor to global morbidity and mortality. Over the past decade, concept of "gut-lung axis" has emerged, offering lens through which examine intricate interplay between host, microbiome, respiratory diseases, including COPD. An expanding body evidence underscores that composition both gastrointestinal microbiome deviates in COPD patients compared healthy individuals, leading distinct host immune responses clinical manifestations. The objective this review provide concise overview role gut play development This was accomplished by compiling current literature on profile stable exacerbated cases COPD, as well exploring biological mechanisms discussion relevant experiments conducted murine models. Hallmark characteristics microbial encompass reduced

Language: Английский

Citations

1
Gastrointestinal cancer and occupational diesel exhaust exposure: a meta-analysis of cohort studies DOI
Giulia Collatuzzo, Federica Teglia,

Paolo Boffetta

et al.

Occupational Medicine, Journal Year: 2024, Volume and Issue: 74(6), P. 438 - 448

Published: June 25, 2024

Diesel exhaust exposure and cancer other than the lungs have been limitedly investigated.

Language: Английский

Citations

1
Evaluating the Role of Glycemic Control in Modulating Pulmonary Function Among Smokers With Diabetes Mellitus: A Systematic Review DOI Open Access

Tanuj Mathur,

Bipin Kumar,

Mamta Dubey

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Background: Diabetes mellitus (DM) impacts multiple body systems, including lung function, and this impact can be further complicated by smoking. The connection between blood sugar control health in individuals with diabetes who smoke has been extensively studied, but findings have varied. This systematic review sought to compile assess the research on how influences function smokers diabetes. Methods: We searched several databases, PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, CINAHL, PsycINFO, Google Scholar, line Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. included studies that looked at tests examined relationship control, as indicated hemoglobin A1c (HbA1c) levels. conducted thorough quality assessments, data extraction, analysis. Results: identified five relevant studies. from these a clear trend: had higher HbA1c levels typically showed worse than those better control. Decreases forced expiratory volume one second (FEV1) vital capacity (FVC) were most frequently observed issues. Some also pointed complex particularly when was below 7.0%. Conclusion: Our indicates DM poor tend function. These highlight importance managing help maintain individuals. Further long-term is needed clarify exact whether improving reverse problems.

Language: Английский

Citations

0
Fusarium graminearum Spores Disrupt Gut Microbiota and Metabolome via the Lung-Gut Axis in Mice DOI
Yuting Wang, Bing Wu,

Xingxing Gao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 479, P. 135573 - 135573

Published: Aug. 30, 2024

Language: Английский

Citations

0
Neighbourhood Urban Environments and Cognitive Health in Ageing Populations DOI

Maria V. Soloveva,

Govinda Poudel, Anthony Barnett

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0