Priroda,
Journal Year:
2023,
Volume and Issue:
10, P. 3 - 12
Published: Jan. 1, 2023
Центросома
—
небольшая
клеточная
органелла,
в
которой
сосредоточено
большое
количество
регуляторных
белков.
Будучи
также
центром
организации
микротрубочек,
центросома
представляет
собой
транспортный
узел
клетки,
из
которого
с
помощью
специфических
белков-моторов
по
микротрубочкам
осуществляется
как
центробежный,
так
и
центростремительный
транспорт
белковых
комплексов,
целых
органелл.
Хотя
за
последние
годы
достигнут
значительный
прогресс
идентификации
сотен
центросомальных
белков,
процесс
формирования
центросомы
еще
недостаточно
изучен.
В
настоящей
статье
изложены
результаты
исследования
процессе
раннего
эмбрионального
развития.
Journal of Assisted Reproduction and Genetics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Spermatozoa
centriolar
defects
can
result
in
abnormal
zygote
functions.
Recently,
a
method
to
quantify
spermatozoa
was
developed
named
Fluorescence-Based
Ratiometric
Analysis
of
Sperm
Centrioles
(FRAC).
However,
whether
identified
by
FRAC
functions
not
tested.
Here,
we
quantified
using
FRAC,
and
centriole
function
assessed
imaging
Nucleolus
Precursor
Body
(NPB)
polarization
which
based
on
the
pattern
NPB
polarization.
Data
analyzed
at
couple
embryo
levels.
Subjects
were
divided
into
two
groups:
seven
couples
62
embryos
with
normal
centrioles
versus
eight
78
(140
from
15
total).
Patterned
statistically
significant
both
couple-
embryo-level
analyses
(p
<
0.0001
p
=
0.0024).
These
results
suggest
that
may
correlate
centrosome
via
scoring.
This
study
provides
foundation
for
more
extensive
studies
test
FRAC's
utility
assessing
quality.
Open Biology,
Journal Year:
2023,
Volume and Issue:
13(11)
Published: Nov. 1, 2023
Centrioles
are
microtubule-based
structures
crucial
for
forming
flagella,
cilia
and
centrosomes.
Through
these
roles,
centrioles
critical
notably
proper
cell
motility,
signalling
division.
Recent
years
have
advanced
significantly
our
understanding
of
the
mechanisms
governing
centriole
assembly
architecture.
Although
typically
very
stable
organelles,
persisting
over
many
cycles,
they
can
also
be
eliminated
in
some
cases.
Here,
we
review
instances
elimination
a
range
species
types.
Moreover,
discuss
potential
that
enable
switch
from
organelle
to
vanishing
one.
Further
work
is
expected
provide
novel
insights
into
health
disease,
thereby
enabling
scientists
readily
manipulate
fate.
FEBS Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 27, 2024
Centrosomes
are
dominant
microtubule
organizing
centers
in
animal
cells
with
a
pair
of
centrioles
at
their
core.
They
template
cilia
during
interphase
and
help
organize
the
mitotic
spindle
for
more
efficient
cell
division.
Here,
we
review
roles
centrosomes
early
developing
mouse
organ
formation.
Mammalian
respond
to
centrosome
loss‐of‐function
by
activating
surveillance
pathway,
timing
mechanism
that,
when
defined
duration
is
exceeded,
leads
p53‐dependent
death
descendants.
Mouse
embryos
without
highly
susceptible
this
pathway
undergo
embryonic
arrest
mid‐gestation.
The
complete
loss
centriolar
core
results
earlier
severe
phenotypes
than
that
other
centrosomal
proteins.
Finally,
different
tissues
possess
varying
thresholds
mount
graded
responses
go
beyond
germ
layer
origin.
Journal of Cell Science,
Journal Year:
2023,
Volume and Issue:
136(23)
Published: Dec. 1, 2023
ABSTRACT
The
centrosome
is
a
non-membrane-bound
organelle
that
conserved
across
most
animal
cells
and
serves
various
functions
throughout
the
cell
cycle.
In
dividing
cells,
known
as
spindle
pole
nucleates
robust
microtubule
to
separate
genetic
material
equally
into
two
daughter
cells.
non-dividing
mother
centriole,
substructure
of
centrosome,
matures
basal
body
cilia,
which
acts
signal-transducing
antenna.
centrosomes
their
substructures
are
important
for
embryonic
development
have
been
studied
extensively
using
in
vitro
mammalian
culture
or
vivo
invertebrate
models.
However,
there
considerable
differences
composition
during
different
aspects
vertebrate
development,
these
less
studied.
this
Review,
we
discuss
roles
played
by
centrosomes,
highlighting
divergent
features
species,
particularly
fertilization
development.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2101 - 2101
Published: Feb. 9, 2024
Chromosome
segregation
in
female
germ
cells
and
early
embryonic
blastomeres
is
known
to
be
highly
prone
errors.
The
resulting
aneuploidy
therefore
the
most
frequent
cause
of
termination
development
embryo
loss
mammals.
And
specific
cases,
when
actually
compatible
with
fetal
development,
it
leads
severe
developmental
disorders.
main
surveillance
mechanism,
which
essential
for
fidelity
chromosome
segregation,
Spindle
Assembly
Checkpoint
(SAC).
although
all
eukaryotic
carry
genes
required
SAC,
not
clear
whether
this
pathway
active
cell
types,
including
embryos.
In
review,
we
will
summarize
discuss
recent
progress
our
understanding
mechanisms
controlling
how
they
might
work
embryos
mammalian
particular.
Our
conclusion
from
current
literature
that
show
limited
capabilities
react
defects,
might,
at
least
partially,
explain
widespread
problem
during
PubMed,
Journal Year:
2023,
Volume and Issue:
2023
Published: Jan. 1, 2023
Centrosomes
play
an
important
role
in
the
microtubule
organization
of
a
cell.
The
sperm's
specialized
centrosome
consists
canonical
barrel-shaped
proximal
centriole,
funnel-shaped
distal
and
pericentriolar
material
known
as
striated
columns
(or
segmented
columns).
Here,
we
examined
localization
centriole
proteins
CEP135
CP110
cattle
human
spermatozoa.
In
centrioles,
is
tip
protein
that
controls
cilia
formation,
while
structural
essential
for
constructing
centriole.
contrast,
found
antibodies
recognizing
label
near
centrioles
at
expected
location
capitulum
humans
antibody
species-specific
way.
These
findings
provide
pathway
to
understanding
unique
functions
spermatozoan
centrosome.
