Assessment and Evaluation of Contemporary Approaches for Astrocyte Differentiation from hiPSCs: A Modeling Paradigm for Alzheimer's Disease

Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)

Published: Sept. 28, 2024

Language: Английский

---

Astrocytic centrin‐2 expression in entorhinal cortex correlates with Alzheimer's disease severity

Glia, Journal Year: 2024, Volume and Issue: 72(12), P. 2158 - 2177

Published: Aug. 15, 2024

Abstract Astrogliosis is a condition shared by acute and chronic neurological diseases includes morphological, proteomic, functional rearrangements of astroglia. In Alzheimer's disease (AD), reactive astrocytes frame amyloid deposits exhibit structural changes associated with the overexpression specific proteins, mostly belonging to intermediate filaments. At level, beta triggers dysfunctional calcium signaling in astrocytes, which contributes maintenance neuroinflammation. Therefore, identification intracellular players that participate astrocyte can help unveil mechanisms underlying reactivity loss function AD. We have recently identified calcium‐binding protein centrin‐2 (CETN2) as novel marker human brain and, order determine whether astrocytic CETN2 expression distribution could be affected neurodegenerative conditions, we examined its pattern control sporadic AD patients. By immunoblot, immunohistochemistry, targeted‐mass spectrometry, report positive correlation between entorhinal immunoreactivity neurocognitive impairment, along abundance depositions neurofibrillary tangles, thus highlighting linear relationship progression. CETN2‐positive were dispersed cortex clustered colocalized glia markers STAT3, NFATc3, YKL‐40, indicating human‐specific role AD‐induced astrogliosis. Collectively, our data provide first evidence part toolkit undergoing adds list proteins play evolution.

Language: Английский

---

The Role of Astrocytes in CNS Disorders: Historic and Contemporary Views

Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1388 - 1388

Published: Aug. 20, 2024

This Special Issue of Cells presents a collection 22 published, peer-reviewed articles on the theme “Astrocytes in CNS Disorders,” including 9 reviews evidence implicating astrocytes etiology specific disorders, and 13 original research papers providing such [...]

Language: Английский

---