International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1110 - 1110
Published: Jan. 16, 2024
This comprehensive review elucidates the profound relationship between human microbiome and breast cancer management. Recent findings highlight significance of microbial alterations in tissue, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancement diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions
Language: Английский
Citations
19Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer
Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2644 - 2644
Published: Aug. 10, 2024
Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.
Language: Английский
Citations
4Interactions between the tumor microbiota and breast cancer
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 24, 2025
Breast cancer is the most common malignancy in women worldwide. Changes microbiota and their metabolites affect occurrence development of breast cancer; however, specific mechanisms are not clear. Gut microbes influence by regulating tumor immune response, estrogen metabolism, chemotherapy, immunotherapy effects. It was previously thought that there were no microorganisms tissue, but it now can outcome disease. This review builds on existing research to comprehensively analyze role gut intratumoral metastasis cancer. We also explore potential function as biomarkers for prognosis therapeutic highlighting need further clarify causal relationship between hope provide new ideas directions methods treatment.
Language: Английский
Citations
0Small Biological Fighters Against Cancer: Viruses, Bacteria, Archaea, Fungi, Protozoa, and Microalgae
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 665 - 665
Published: March 8, 2025
Despite the progress made in oncological theranostics, cancer remains a global health problem and leading cause of death worldwide. Multidrug radiation therapy resistance is an important challenge treatment. To overcome this great concern clinical practice, conventional therapies are more used combination with modern approaches to improve quality patients’ lives. In review, we emphasize how small biological entities, such as viruses, bacteria, archaea, fungi, protozoans, microalgae, well their related structural compounds toxins/metabolites/bioactive molecules, can prevent suppress or regulate malignant initiation, progression, metastasis, responses different therapies. All these fighters free-living parasitic nature and, furthermore, protozoans components human animal microbiomes. Recently, polymorphic microbiomes have been recognized new emerging hallmark cancer. Fortunately, there no limit development novel biomedicine. Thus, viral vector-based based on genetically engineered bacteriotherapy, mycotherapy anti-cancer fungal bioactive compounds, use protozoan parasite-derived proteins, nanoarchaeosomes, microalgae-based microrobots oncology, promoting biomimetic biology-inspired strategies maximize diagnostic efficiency, improved life.
Language: Английский
Citations
0Aromatics from fossil fuels and breast cancer
iScience, Journal Year: 2025, Volume and Issue: unknown, P. 112204 - 112204
Published: March 1, 2025
Polycyclic aromatic hydrocarbons (PAHs) from fossil fuels initiate breast cancer in animal models, and humans a link between PAH exposure risk has been established. In women, it takes approximately two decades for PAH-exposed cells to progress diagnosable cancer, the needs happen during time window when is vulnerable PAHs. Further, not everyone exposed high levels of PAHs develops cancer. are most likely lead initiation among individuals who were utero through pregnant mothers environmental pollutants or maternal obesity both. These early life exposures shown increase daughter's later susceptibility by causing daughter (1) an number structures which place, (2) suppression, perhaps epigenetically, ability repair DNA damage caused inhibiting expression tumor suppressor genes, (3) persistent gut dysbiosis, then impacts immune microenvironment. Among that may be volatile BTEX compounds. Thus, aromatics involved efforts should directed toward reducing human these compounds prevent
Language: Английский
Citations
0Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2040 - 2040
Published: March 17, 2025
Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.
Language: Английский
Citations
0Huaier enhances the antitumor effects of CDK 4/6 inhibitor by remodeling the immune microenvironment and gut microbiota in breast cancer
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119723 - 119723
Published: April 1, 2025
Language: Английский
Citations
0Therapeutic potential of microbiome modulation in reproductive cancers
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: April 6, 2025
Language: Английский
Citations
0Insights into the gut microbiome-metabolite dynamics in breast cancer
Gut Microbes Reports, Journal Year: 2025, Volume and Issue: 2(1), P. 1 - 23
Published: April 9, 2025
Language: Английский
Citations
0Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 990 - 990
Published: April 18, 2025
Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic ERβ exhibiting tumor-suppressive properties. The interaction between ER signaling other molecular pathways, such as PI3K/AKT/mTOR, influences tumor growth endocrine resistance. Emerging research highlights the of prebiotics modulating gut microbiota, which may influence estrogen metabolism, immune function, therapeutic responses BC. This review explores impact on receptor modulation, microbiota composition, regulation, metabolic pathways cancer. potential adjunctive therapies to enhance treatment efficacy mitigate chemotherapy-related side effects is discussed. A comprehensive analysis recent preclinical clinical studies was conducted, examining reprogramming short-chain fatty acids (SCFAs) derived from prebiotic fermentation epigenetic regulation resistance also evaluated. Prebiotics were found modulate microbiota-estrogen axis, reduce inflammation, responses. SCFAs demonstrated selective downregulation reprogramming, suppressing growth. Synbiotic interventions effects, improving quality life patients. offer promising avenue for prevention therapy by pathways. Future trials are needed validate their treatments management.
Language: Английский
Citations
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