Cited by NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain

Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy DOI

Michael Qize Jiang,

Shan Ping Yu,

Takira Estaba

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 897 - 897

Published: May 23, 2024

Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem (iNSCs) and neurons (iNeurons), provides genetic tools manipulate cell’s fate potential therapy for neurological diseases. NeuroD1 (ND1) master transcriptional factor neurogenesis it promotes neuronal differentiation. In the present study, we tested hypothesis that expression ND1 in GBM can force them differentiate toward post-mitotic halt progression. cultured human lines, including LN229, U87, U373 temozolomide (TMZ)-sensitive T98G TMZ-resistant cells, lineage conversion was by adeno-associated virus (AAV) package carrying ND1. Twenty-one days after AAV-ND1 transduction, ND1-expressing displayed markers MAP2, TUJ1, NeuN. The ND1-induced transdifferentiation regulated Wnt signaling markedly enhanced under hypoxic condition (2% O2 vs. 21% O2). cultures had fewer BrdU-positive proliferating compared vector control cultures. Increased death visualized TUNEL staining, reduced migrative activity demonstrated wound-healing test both TMZ-sensitive -resistant cells. striking contrast cancer converted expressed anti-tumor gene p53. orthotopical mouse model, AAV-ND1-reprogrammed were transplanted into fornix cyclosporine-immunocompromised C57BL/6 brain. Compared cell-formed tumors, from ND1-reprogrammed formed smaller tumors TUJ1 Thus, using single-factor overcame drug resistance, converting malignant heterogeneous normal neuron-like vitro vivo. These novel observations warrant further research patient-derived xenograft (PDX) models potentially effective treatment deadly likely other astrocytoma tumors.

Language: Английский

Citations

Fabrication of temozolomide-loaded polydopamine-coated copper ferrite clocked bovine serum albumin nanoparticles delivery for glioma cancer and induction of apoptosis mechanism DOI

Can Zhu,

Huaming Chen,

Ziyu Chen

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106642 - 106642

Published: Jan. 1, 2025

Language: Английский

Citations

Zingerone based green synthesized sodium doped zinc oxide nanoparticles eliminate U87 glioblastoma cells by inducing apoptosis DOI

Saman Parsaei,

Hajar Yaghoobi, Pezhman Beshkar

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 19, 2025

Grade IV astrocytoma, also referred to as glioblastoma (GBM), is the most common type of glioma, accounting for over 60% all brain tumors. It still a fatal illness in spite years investigation and does not currently have treatment. Thus, scientists medical professionals are constantly trying understand molecular processes heterogeneity GBM well looking new ways improve treatment results. Numerous studies indicated that nanomaterials, more especially nanoparticles, offer great deal potential killing cancer cells; result, they being considered alternative Several demonstrated ZnO NPs shown specific cytotoxicity against cells while leaving normal unharmed. In this study we aim synthesize sodium doped zinc oxide using zingerone an environmentally friendly manner evaluate their cytotoxic effects on U87 cell line HEK investigate occurrence apoptosis via assay by flowcytometry gene expression TP53 related genes cycle regulation pathways. was Na-doped had significant effect having significantly less cells. eliminated cancerous through induction possibly up-regulation TP53, PTEN, BAX, P21 down-regulation Bcl2. The unique physicochemical properties nanoparticles turn them into fascinating agents treat GBM. Hence, necessity exploring vast, yet unknown field potentials cannot be looked.

Language: Английский

Citations

New ALKBH2 and ALKBH5 inhibitors for treating glioblastoma DOI

Mirko Rivara, Gabriella Nicolini, Alessio Malacrida

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 9, P. 101645 - 101645

Published: July 1, 2024

Glioblastoma is an aggressive brain tumor with high mortality and a median survival of about 15 months. Starting from our previous published compound, MV1035 that inhibited migration invasiveness glioblastoma U87 cells, also exhibited synergic effect in combination the alkylating agent Temozolomide, we identified new active molecules, aim to understand key motifs responsible for activity against DNA repair protein ALKBH2 RNA demethylase ALKBH5. We modified original structure MV1035, synthesizing molecules have been tested through MTT assay, cell-free assay ALKBH5 assay. found compound 6 able reduce both obtained important information these inhibitors. However, considering complexity, heterogeneity plasticity GBM GSC will need be validated vivo.

Language: Английский

Citations

NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain DOI

Mengjie Gao,

Zhiqiang Cui, Yue Shen

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110098 - 110098

Published: June 1, 2024

Language: Английский

Citations