The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches DOI Creative Commons
Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 18 - 18

Published: Dec. 26, 2024

The biological process of aging is influenced by a complex interplay genetic, environmental, and epigenetic factors. Recent advancements in the fields epigenetics senolytics offer promising avenues for understanding addressing age-related diseases. Epigenetics refers to heritable changes gene expression without altering DNA sequence, with mechanisms like methylation, histone modification, non-coding RNA regulation playing critical roles aging. Senolytics, class drugs targeting eliminating senescent cells, address accumulation dysfunctional cells that contribute tissue degradation chronic inflammation through senescence-associated secretory phenotype. This scoping review examines intersection senolytic therapies aging, focusing on their combined potential therapeutic interventions. Senescent display distinct signatures, such as hypermethylation modifications, which can be targeted enhance efficacy. Epigenetic reprogramming strategies, induced pluripotent stem may further complement rejuvenating aged cells. Integrating modulation therapy offers dual approach improving healthspan mitigating pathologies. narrative underscores need continued research into molecular underlying these interactions suggests future directions development, including clinical trials, biomarker discovery, combination synergistically target processes.

Language: Английский

MiR-335-5p Escaped from CircKIAA0586 Adsorption Contributes to Mechanical Overloading-induced Cartilage Degeneration by Targeting HELLS DOI Creative Commons

Haoyu Xie,

Yuheng Lu, Jianying Pan

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Mechanical overload is a critical contributor to cartilage degeneration in osteoarthritis (OA) pathogenesis. Circular RNA (circRNA) expected provide long-lasting therapy for OA. However, the involvement of circRNA-associated competitive endogenous network chondrocyte senescence induced by mechanical overloading remains unestablished. A overloading-induced model human primary chondrocytes constructed, and differences expression circRNAs miRNAs were analyzed. The biological roles circKIAA0586/miR-335-5p OA progression under its downstream targets determined using gain- loss-of-function experiments various biochemical assays chondrocytes. vivo effects circKIAA0586 overexpression also destabilization medial meniscus (DMM) mice aged spontaneous mice. was aggravated miR-335-5p or knockdown. Accumulated DNA damage response observed following overloading, which reduced after inhibition supplementation. MiR-335-5p regulated circKIA0586 adsorption. HELLS prominently down-regulated treatment. Moreover, bound lymphoid-specific helicase (HELLS) mRNA during demonstrated mediate nonhomologous end joining (NHEJ) pathway, thereby inducing senescence. In addition, delaying protective functions validated DMM Our findings suggest that miR-335-5p, escapes adsorption, facilitates impairing NHEJ pathway through inhibition. Overall, targeting circKIAA0586/miR-335-5p/HELLS signaling provides novel therapeutic approach

Language: Английский

Citations

0
Biological roles of SLC16A1-AS1 lncRNA and its clinical impacts in tumors DOI Creative Commons
Bing Liao, Jialing Wang, Yalin Yuan

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 30, 2024

Language: Английский

Citations

1
The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches DOI Creative Commons
Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 18 - 18

Published: Dec. 26, 2024

The biological process of aging is influenced by a complex interplay genetic, environmental, and epigenetic factors. Recent advancements in the fields epigenetics senolytics offer promising avenues for understanding addressing age-related diseases. Epigenetics refers to heritable changes gene expression without altering DNA sequence, with mechanisms like methylation, histone modification, non-coding RNA regulation playing critical roles aging. Senolytics, class drugs targeting eliminating senescent cells, address accumulation dysfunctional cells that contribute tissue degradation chronic inflammation through senescence-associated secretory phenotype. This scoping review examines intersection senolytic therapies aging, focusing on their combined potential therapeutic interventions. Senescent display distinct signatures, such as hypermethylation modifications, which can be targeted enhance efficacy. Epigenetic reprogramming strategies, induced pluripotent stem may further complement rejuvenating aged cells. Integrating modulation therapy offers dual approach improving healthspan mitigating pathologies. narrative underscores need continued research into molecular underlying these interactions suggests future directions development, including clinical trials, biomarker discovery, combination synergistically target processes.

Language: Английский

Citations

0