Oxidative Stress and Age-Related Tumors

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1109 - 1109

Published: Sept. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Language: Английский

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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 114 - 114

Published: Jan. 20, 2025

Oxidative stress is a state of imbalance between the production reactive oxygen species (ROS) and nitrogen (RNS) antioxidant defence system in body. may be associated with variety diseases, such as ovarian cancer, diabetes mellitus, neurodegeneration. The generation oxidative one common refractory malignancies among gynaecological tumours, several factors. On hand, increased metabolism cancer cells can lead to ROS, on other impaired not able effectively scavenge excessive ROS. In addition, chemotherapy radiotherapy elevate cells. cause damage, promote development even result drug resistance. Therefore, studying important for prevention treatment cancer. Antioxidants, markers stress, might serve strategies preventing treating this review, we will discuss complex relationship well role therapeutic potential antioxidants thus guiding future research clinical interventions.

Language: Английский

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Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12387 - 12387

Published: Nov. 18, 2024

Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve signaling agents that enhance cell proliferation, migration, resistance to drugs. However, at elevated levels, induce oxidative stress, causing damage biomolecules leading death. cells developed mechanisms manage activating pathways such NRF2, NF-κB, PI3K/Akt. This review explores relationship between cancer, focusing on death like apoptosis, ferroptosis, autophagy, highlighting potential strategies exploit target cells.

Language: Английский

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Integration of In Vitro and In-Silico Analysis of Gracilaria edulis on Anti-Cancer Potential and Apoptotic Signaling Pathway Activity

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Prognostic and predictive values of a multimodal nomogram incorporating tumor and peritumor morphology with immune status in resectable lung adenocarcinoma

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(3), P. e010723 - e010723

Published: March 1, 2025

Background Current prognostic and predictive biomarkers for lung adenocarcinoma (LUAD) predominantly rely on unimodal approaches, limiting their characterization ability. There is an urgent need a comprehensive accurate biomarker to guide individualized adjuvant therapy decisions. Methods In this retrospective study, data from patients with resectable LUAD (stage I–III) were collected two hospitals publicly available dataset, forming training dataset (n=223), validation (n=95), testing (n=449), the non-small cell cancer (NSCLC) Radiogenomics (n=59). Tumor peritumor scores constructed preoperative CT radiomics features (shape/intensity/texture). An immune score was derived density of tumor-infiltrating lymphocytes (TILs) within epithelium stroma hematoxylin eosin-stained whole-slide images. A clinical based clinicopathological risk factors. Cox regression model employed integrate these scores, thereby constructing multimodal nomogram predict disease-free survival (DFS). The chemotherapy benefit rate subsequently calculated nomogram. Results outperformed each in predicting DFS, C-index 0.769 (vs 0.634–0.731) 0.730 0.548–0.713) 0.751 0.660–0.692) dataset. It independently associated DFS after adjusting other factors (training dataset: HR=3.02, p<0.001; HR=2.33, HR=2.03, p=0.001). effectively distinguished between benefiting those observation alone (interaction p<0.001). Furthermore, high-/low-risk groups defined by provided refined stratification candidates identified current guidelines (p<0.001). Gene set enrichment analyses using NSCLC revealed associations tumor/peritumor pathways involved epithelial-mesenchymal transition, angiogenesis, IL6-JAK-STAT3 signaling, reactive oxidative species. Conclusion nomogram, which incorporates tumor morphology anti-tumor response, provides superior accuracy compared scores. Its rates can inform

Language: Английский

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Association between oxidative balance score and all-cause and cancer-specific mortality among cancer survivors

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

The Oxidative Balance Score (OBS) represents a novel metric for assessing systemic oxidative stress, where elevated scores reflect increased antioxidant exposure. This study aims to explore the association between OBS and all-cause cancer-specific mortality among cancer survivors. An observational cohort was conducted involving 4099 survivors, utilizing data obtained from National Health Nutrition Examination Survey (NHANES) covering years 1999 2018. endpoints were established by cross-referencing with Death Index (NDI). developed based on dietary lifestyle factors. Cox proportional hazards regression models employed examine relationship risks. Restricted cubic spline utilized evaluate whether exhibited nonlinear risk of death. Furthermore, Kaplan-Meier survival curves generated assess cumulative differences across various outcomes. Over an average follow-up 84.00 months, 1481 (26.29%) participants died, including 484 (8.9%) who died cancer. In fully adjusted model, multivariable revealed that each unit increase in linked 1.8% decrease (HR 0.982, 95%CI 0.972-0.991) 2.6% 0.974, 0.958-0.991). context mortality, death found be significantly lower quartiles Q2, Q3 Q4 when compared quartile Q1. hazard ratios (HRs) 95% confidence intervals (CIs) as follows: Q2 0.833, 0.707-0.981), 0.789, 0.650-0.958) 0.699, 0.579-0.844). Regarding HRs 95%CIs comparison Q1 0.663, 0.505-0.869), 0.688, 0.488-0.969) 0.595, 0.435-0.815). Similar associations noted components analyzed separately. findings indicate higher levels are associated Our may contribute refinement intervention recommendations this population.

Language: Английский

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Bevacizumab and cytostatics induce oxidative changes in the submandibular gland of male rats

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106248 - 106248

Published: March 1, 2025

Language: Английский

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Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

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N-acetylcysteine remodels the tumor microenvironment of primary and recurrent mouse glioblastoma

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

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Broccoli and Arthritis: A Review

Food Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Arthritis is a disease characterized by joint pain, swelling, and limited mobility also major cause of disability. Osteoarthritis (OA) rheumatoid arthritis (RA) are the two most common manifestations arthritis, they share many risk factors pathogenic features. At present, there no effective approach to prevent or slow its progress. Nonetheless, treatments can alleviate symptoms improve quality life patients. Among, antioxidant supplement therapy has become one popular methods as it inhibit formation reactive oxygen species (ROS) in chondrocytes, which key step pathogenesis arthritis. Broccoli rich essential nutrients, including fibers, vitamins, minerals, various bioactive components. Thus, dietary broccoli holds potential preventive measure against due widespread popularity, safety profile, affordability. However, review clinical pre‐clinical studies on available so far. Therefore, this systematic aims critically evaluate efficacy constituents treatment Although current evidence falls short establishing definitive effect number significant heterogeneity among existing research, research provides overall support for benefits components preventing managing use an adjuvant individuals with

Language: Английский

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